Doctor insights on:
Metastatic Colon Cancer To The Omentum
Possible: But less than 20% survive 5 years. Depends on where the metastases are and how numerous and size. Solitary liver mets without evidence elsewhere in the body can be cured with a liver resection. Diffuse mets to numerous body parts rarelyare curable. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Cancer that spread: Metastatic means that the colon cancer has spread to other parts of your body. This can happen when the cells get into your blood or the lymph system and travel to other places. Cancer cells can also spread to nearby tissue or organs via direct contact. The most common places for colon cancer to spread to are: lymph nodes, liver, lungs, and the peritoneum (a membrane in your abdominal cavity). ...Read more
If a met is localized to one or two areas in the liver, or other organ, and can be removed, there can be a cure. Chemotherapy is used after surgery in that case.
In general we have advanced in our ability to control mets from colon cancer with chemotherapy and immunotherapy.
It all depends on the details and the response to treatment. ...Read more
Can be serious: Metastatic colon cancer often involves the bones, including the vertebrae that protect the spinal cord and provide support to your body. If you are having difficulty walking, the worst case scenario is having a metastatic lesion involve a vertebral body, and possibly causing nerve damage by compressing the spinal cord. As this can be very serious, you should consult your oncologist immediately. ...Read more
Xeloda (capecitabine) can be used as a single agent to treat stage IV metastatic colorectal cancer. The usual dose is 1250 mg/m2 twice daily orally for 14 days, followed by a 7-day rest period for a total cycle time of 21 days.
Adjuvant treatment is recommended for a total of 6 months (8 cycles). Doses may be altered for individual situations with reduced doses for patients with kidney problems. ...Read more
Would Xeloda (capecitabine) be as effective for metastatic colon cancer taken one week on one week off?
Yes: There are different schedules for giving xeloda (capecitabine). The key is to give it in a way that's effective, but also decrease possible side effects. The "typical" schedule for Xeloda (capecitabine) is to take it twice daily for two week followed by a week off. However, the build-up of drug in the body causes more side effects than taking the drug twice daily for one week followed by a week off. And it works as well! ...Read more
Yes, it can be an op: This pill is often used in Japan. So it is not popular in the US. Moreover, it is better to be treated with a combination of 2 or 3 medicines that are proven useful in the treatment of metastatic colon Cancer. I would advise you to seek a second opinion so that you can make sure that your treatment is not substandard. ...Read more
My sister is on chemotherapy (folfox for metastatic colon cancer). Recent blood test shows high WBC (14, 000) and platelets (429). Is this okay?
No worries.: High WBC can be due to many causes: infection, stress, steroid use, dehydration, or the use of growth factor (such as neupogen). If there is no evidence of infection, then there is nothing to worry about. High platelet count is not uncommon since it is a body's reaction to stress of any cause (platelet is an acute phase reactant). Again, nothing to worry about. All the best, hk. ...Read more
I have metastatic melanoma x 10yrs. Last year it was in my lung and treated with chemo. Ferritin is 20. Heard sign of colon cancer? Any other cancer?
Depending how used: CEA first identified in 1965 by Phil Gold and Samuel O. Freedman in human colon cancer extracts. Thought to be valuable for dx colorectal Ca but the glycoprotein is also expressed in inflamed tissue so that smoking and enema can cause rise. Best used for monitoring so that if present in primary and rises it represents treatment failure and if diminishes during treatment it represents a response. ...Read more
Work w/ your Dr:
This is worth discussing w/ your Dr or getting a 2nd opinion. They spent years building a knowledge base and also have examined you! Some research finds it less beneficial alone than in combo: http://www. Ncbi. Nlm. Nih. Gov/pubmed/24560487
But talk about your case w/ your team. ...Read more
Uncertain: This sounds like an extraordinarily high value, and indicates either blockage if the bile flowing out of the liver, or failing liver function. It may or may not be due to the cancer, but is typically an ominous sign. Talk more about this with the treating physician. Hope this helps! ...Read more
So many variables: Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions ...Read more
What kind of mets:
It depends what kind of metastases we are talking about.
if the spread to the lymph nodes, surgery and chemotherapy, and possible radiation therapy could be very helpful.
if the spread to the liver the prognosis is less optimistic, unless the metastases are able to be resected.
other metastases are less promising in spite of chemotherapy and radiation therapy. Like bone and brain. ...Read more
Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more
I mean if chemotherapy does not work fir metastic colon cancer, can anything be done, any new drugs?
Yes: Depending where mets are, direct therapy can be offered resecting lung lesions locally, using chemoembolization for lesions in liver and hyperthermic perfusion for peritoneal seeding. Immunotherapy for VEGF and epidermal growth factors can also be employed as well as new drugs in Phase II-III such as mAbs targeting post translational modification of MUC5ac and CEAcam 5, 6`oncofetal proteins/ ...Read more
ALT reading -50 ALP reading -140 Bilirubin 74 Is this suggestive of liver failing Metastic colon cancer?
Liver function: The enzymes (ALP & ALT) are indicative of only mild liver dysfunction. The rising bili suggests that some degree of bile obstruction may be occurring. This could be due to the mechanical obstruction of small ducts by metastatic disease. But the liver has a large degree of reserve capacity, so full liver failure is unlikely to be final cause of death even with very bulky mets. ...Read more
An average response to chemotherapy for Colon cancer lasts 9 to 12 months (range from 6 months to 2 years).
But it depends on how many tumors you have and their original size and the degree of tumor regression (shrinkage). Some tumors can regress nicely and may even go away, in which case you can gain some years of life and an occasional Cure is even possible. Ask your doctor to further address thi ...Read more
Dehydration Ca Colon: Hello Kanabar T, YES it can but only as part of the process of succumbing from it, since Stage 4 means it is spread throughout the body. This would be an excellent cause for a referral to Hospice. Thanks ...Read more
Some response: Meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more
Modestly effective: Fluoropyrimidines (5-FU, Capecitabine and UFT) as a class have modest activity and one of these 3 needs to be combined with Oxaliplatin and or Irinotecan to achieve best results, as combination chemo is far superior in efficacy than any single chemo drug ...Read more
Yes: In colon cancer as with most malignancies as the lesion increases in size the greater the population of mutated cells with varying surface glycoproteins defining different sites of metastasis. With the metastasis alreadyu present each of these cells express a mutated form of mitochondrial DNA acting as immunogenic inhibitory molecules making treatment more difficult. ...Read more
Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read more
Not always reliable: I assume that from ALP you meant Alkaline Phosphatase (a type of liver function test). But avoid using abbreviations. This test can sometimes be correct in showing tumor progression but we need more information than this test alone in order to assess tumor response. The additional tests that help are measuring the liver size, checking CEA level (Blood test) and for making final decision, CT scan. ...Read more