Doctor insights on:
Metastasis Vs Metastases
A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site ...Read more
Hepatic mets: I think you mean what cancers can cause hepatic mets. It usually happens when cancer spread through blood circulation in liver. Many different type of cancer can spread to liver. Most commonly colon, any cancer of digestive system and lung cancer. But mostly any cancer can spread to liver. ...Read more
Peritoneal mets: This is a very difficult area to treat. It depends first on where the spread is from...ovaries, colon, uterus...etc. Some cases will be managed with surgery others will receive chemo. Radiation is not a great tool to use since this is a large area and lots of sensitive organs. ...Read more
Close exam: Primary tumor cells are well defined, arising in the organ that initiates the lesion. A cancer of the breast when biopsied shows adenoca cells of breast origin. When metastatic to liver or lung, biopsy will show the same cells as the primary. If the lesion arises in the liver it is not metastatic in terms of cells seen but liver tumor cells or hepatoma. ...Read more
Pancreas cancer has a poor prognosis. No survival noted if performed in the presence of metastatic disease. Use of chemotherapy such as gemcitabine and Abraxane give the best chance for prolonged survival in terms of months after diagnosis made.
Only 10% or patients diagnosed with pancreatic head cancer are candidates for a whipple resection, and even here only 10% of patients are ned at 2 yrs. ...Read more
Submax region: Oral low grade adenocarcinomas are relatively rare. Since the major portion of the oral cavity is squamous cells lining the cavity, squamous Ca is most frequently found. The adenocarcinomas arising from glandular tissue arise from the minor salivary gland lining the cheeks and areas like sublingual glands which when harboring malignancies, spread is to the upper cerival or submax region. ...Read more
I was wondering what are the most common areas of infiltrative metastases for oral low-grade adenocarcinoma?
Unclear: Your question is not clear to me. Please expand and explain it better. Most oral cancers spread to the upper neck lymph nodes. ...Read more
Varies: Bone metastases features can vary. Some are bone "lytic" (moth eaten) such as squamous cell cancers or multiple myeloma. Others are "blastic" such as breast, prostate, etc. Symptoms vary from asymptomatic to painful. Bones may easily (pathologically) fracture. Treatment can include bone directed therapy such as bisphosphonates, xgeva (denosumab), radiation, radio frequency ablation, v-plasty. ...Read more
Oncology: The nano knife has been FDA approved in 2009 for the surgical ablation of soft tissue, however it has not been approved to treat other specific diseases or conditions. With metastatic cancer your case sounds more complex and worthy of clinical trial status so it is best to consult with your treating oncologist. Be well:) ...Read more
Yes: Multiple liver lesions can be treated by a number of approaches because what is in liver will not spread. Originally ligation of hepatic artery was used since portal vein supplies hepatocytes and hepatic artery the metastatic tumors. Can be used with SIRT which is a form of RT treatment wherein a dose of SIR-Spheres® microspheres are delivered up to 40 times higher than conventional doses. ...Read more
X-ray, bone scan: Sometimes bone metastases (bone mets) are found before they have a chance to cause any symptoms. When you are found to have cancer, your doctor may order tests (like x-rays or bone scans) to see how far the cancer has spread. This may be done before, during, and after treatment. In other cases, a symptom such as bone pain may be the first sign of bone mets. ...Read more
Like termites,: Abnormal cells destroy bone integrity after traveling from the cancer by the blood stream to a new place. When they grow, they can cause bones to collapse, leading to pain and fracture, or expand causing pain. In many tumors, this is characteristic (prostate, myeloma), treatment can be chemical, radiotherapy, and surgery. ...Read more
Brain mets: Breast cancer can spread to lymph glands, lung, liver, bones as well as brain. Nowadays, with many different chemotherapies and other biological/targeted treatment available for breast cancer -that makes patients with breast cancer live longer, the incidence of brain metastasis increases, unfortunately. ...Read more
Yes. Not always.: Not all bony metastases give you pain- depending on the size and the location. When it gets bigger, pain will manifest and there is significant risk for bone fracture. Therapy for bony metastases wll include- chemotherapy for that particular cancer; palliative radiation to reduce pain/symptoms, some times surgery can be done (very selected case); and bisphosphonates such as zometa or x-geva. ...Read more
Resect if possible:
Liver metastases are an unfortunate consequence of some cancers. Sometimes they are can be removed with surgery if the patient can tolerate it.
Many times surgery is not possible, so patients need to take chemotherapy. Chemotherapy would be chosen depending on the original cancer.
Combinations of surgical removal and chemotherapy have led to long prognosis in colorectal cancer, for example. ...Read more
What is the best imaging for lymp node in the chest? ? And what is the best imaging for ribs metastases? ?
Lymph nodes: The best way to image lymph nodes in the chest is a contrast-enhanced CT scan. As far as rib metastases, several different choices exist, depending on the clinical question. Bone scan is good for detecting the presence of bone mets, PET/CT also for better anatomic detail with known tumors. Standard CT can also be useful, especially if chest ct already being performed for adenopathy. ...Read more
It depends: There are 2 factors that are important. One is the type of cancer and the second is the response to treatment. For metastatic breast or prostate cancer to bone that responds to hormone treatment it could be years. For melanoma that is not responsive it could be a few months. ...Read more
Hard to day.: Depends on the tumor type and aggressiveness. Some tumors may respond to chemo and radiation for years. Others may be rapidly progressive and spread to other organs like liver and brain. A, "cure" is not in the cards. ...Read more
Bone mets: Bone metastases can cause focal areas of bone loss or destruction, called "osteolytic". If they cause a focal bone response of increased density or sclerosis, they are called "osteoblastic". "Ill-defined" means that the borders of the bone met are not clearly visualized, which may imply a faster growing or more aggressive met. Slow growing or indolent lesions tend to develop well defined margin ...Read more
Unlikely: Fever is due to a breakdown in the presence of a malignant lesion. Vomiting is due to reverse peristalsis of the GI tract. Liver metastasis regardless of origin is clonal in origin and cant spread from liver to involve GI tract. Liver mets are well vascularize and fed from hepatic artery so to damage tumor one must embolize the arterial branch feeding tumor. ...Read more