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Doctor insights on: Metachromatic Leukodystrophy Life Expectancy

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What is the life expectancy for patients with leukodystrophy?

What is the life expectancy for patients with leukodystrophy?

Leukodystroph course: Mld is a severe disease that gets worse over time. Eventually people lose all muscle and mental function. Life span varies depending on what age the condition started, but the disease course usually runs 3 - 20 or more years. See: http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002185/. ...Read more

Dr. Michel Philippart
18 Doctors shared insights

Leukodystrophy (Definition)

Leukodystrophy is a metabolic disorder that affects the brain and nervous system. Myelin which is the insulation around nerve cells is defective in leukodystrophy. It is a progressive disorder meaning that it gets worse ...Read more


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My wife has periventricular leukodystrophy. She got it at 59 and is now 60. Life expectancy?

Are you sure of dx?: This is not my area of expertise in neurology, but are you sure it is periventricular leukodystrophy and not periventricular leukomalacia. The former is a condition usually seen in children. The latter is extremely common and is sometimes called small vessel white matter disease. Most patients with a western diet have some degree of this, particularly by age 60, and Aspirin is the treatment. ...Read more

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What is the life expectancy of a 17 year old with leukodystraphy?

What is the life expectancy of a 17 year old with leukodystraphy?

Depends on type: The leukodystrophies are a family of progressive neurologic diseases that are generally fatal and particularly cruel. I wish you comfort in dealing with this difficult problem, and hope that junior's comfort nad dignity can be preserved. ...Read more

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How is life for patients who has leukodystrophy?

Leukodystroph course: Mld is a severe disease that gets worse over time. Eventually people lose all muscle and mental function. Life span varies depending on what age the condition started, but the disease course usually runs 3 - 20 or more years. See: http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002185/. ...Read more

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How much is duration of life for patients newly diagnosed with leukodystrophy?

How much is duration of life for patients newly diagnosed with leukodystrophy?

Depends on type/form: For example, infantile metachromatic leukodystrophy onset is by age 2, with 50-60% morbidity by 5. Juvenile onset between age 4-10 (20-30% of cases) has slower progression. There are 2 adult-onset forms, one starts with neurologic/motor problems, the other with behavioral challenges. Please ask the attending specialist. ...Read more

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What occurs at the end stages of metachromatic leukodystrophy?

What occurs at the end stages of metachromatic leukodystrophy?

Palliative care: You have my sympathy. My hope is that when the end time comes, the patient will be allowed to go with comfort and dignity. Https://behindthezine. Wordpress. Com/tag/metachromatic-leukodystrophy/. ...Read more

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What happens in the end stages of metachromatic leukodystrophy?

Leukodystroph course: Mld is a severe disease that gets worse over time. Eventually people lose all muscle and mental function. Life span varies depending on what age the condition started, but the disease course usually runs 3 - 20 or more years. See: http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002185/. ...Read more

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Are leukodystrophies like metachromatic leukodystrophy (mld) treatable?

Are leukodystrophies like metachromatic leukodystrophy (mld) treatable?

Leukodystrophy: There is no cure for mld. Bone marrow transplantation may delay progression of the disease in some cases. Other treatment is symptomatic and supportive. Considerable progress has been made with regard to gene therapy in an animal model of mld.
(http://www. Ninds. Nih. Gov/disorders/metachromatic_leukodystrophy/metachromatic_leukodystrophy. Htm). ...Read more

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What is metachromatic leukodystrophy?

What is metachromatic leukodystrophy?

MLD: Is a lysosomal storage disease affecting myelin growth, the insulator of nerve fibers, affecting lipid metabolism. It leads to progressive dementia in adults. ...Read more

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What is metachromatic-leukodystrophy? What causes it?

A genetic disorder: Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. This accumulation especially affects cells in the nervous system that produce myelin, the substance that insulates and protects nerves
This is a link to the genetic website with more information
http://ghr. Nlm. Nih. Gov/condition/metachromatic-leukodystrophy ...Read more

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What happens at the end of metachromatic leukodystrophy?

What happens at the end of metachromatic leukodystrophy?

Loss of function: This is a very rare disease, inherited when both parents are usually carriers. Because of the deficient enzyme, arylsulfatase a, patients suffer from a gradual destruction of myelin sheath, the protective covering of nerves. At the end, loss of muscle function, seizures, possibly coma, and mental illness (in older people) prevail. Unfortunately, no cure, though therapies may improve life quality. ...Read more

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Is leukodystrophy a sex-linked condition?

Is leukodystrophy a sex-linked condition?

Sometimes: Some of the leukodystrophies, such as adrenoleukodystrophy, are sex-linked, but many others are not. Please see this web page for more information and links: http://www. Ninds. Nih. Gov/disorders/leukodystrophy/leukodystrophy. Htm. ...Read more

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What is the definition or description of: Leukodystrophy?

What is the definition or description of: Leukodystrophy?

Leukodystrophy: Leukodystrophy is a metabolic disorder that affects the brain and nervous system. Myelin which is the insulation around nerve cells is defective in leukodystrophy. It is a progressive disorder meaning that it gets worse as a patient ages. ...Read more

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What are the tests for leukodystrophies?

What are the tests for leukodystrophies?

Leukodystrophy tests: Neurodevelopmental tests demonstrate the following findings in patients with infantile or early juvenile metachromatic leukodystrophy:

•loss of previously achieved developmental milestones
•tremors
•truncal ataxia
•hyperreflexia progressing to hyporeflexia
hypotonia
gait abnormalities
•optic atrophy
neurocognitive tests demonstrate other abnormalities. ...Read more

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What can you tell me about leukodystrophies?

What can you tell me about leukodystrophies?

Leukodystrophy: Metachromatic leukodystrophy (mld) is a genetic disorder that affects nerves, muscles, other organs, and behavior. It slowly gets worse over time.
Mld is usually caused by the lack of an important enzyme called arylsulfatase a. Because this enzyme is missing, chemicals called sulfatides build up in and damage the nervous system, kidneys, gallbladder, and other organs. Http://www. Ncbi. Nlm. Nih. Gov/p. ...Read more

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Are there any homeopathic cures for leukodystrophy?

Doubt it: I do not know of any effective homeopathic treatments for any illness, let alone one as serious as leukodystrophy. ...Read more

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What condition is also known as krabbe leukodystrophy?

What condition is also known as krabbe leukodystrophy?

Globoid cell: This is one of the leukodystrophies, a genetic disease, of the nervous system. Myelin, the covering around nerves, is destroyed causing brain damage. There is a deficiency of the enzyme, galactocerebrosidase. This disease mostly affects infants but can occur at any age. Unfortunately there is no cure. ...Read more

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Can you tell me about the disease called leukodystrophy?

Can you tell me about the disease called leukodystrophy?

Lose white matter: There are a group of diseases, mostly genetic, in which the white matter of the brain is selectively damaged. Sometimes the white matter nearest to the outer gray matter is relatively spared, making the motor and sensory problems worse than the cognitive deficits. ...Read more

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Could someone please tell me does leukodystrophy make you feel so tired?

Could someone please tell me does leukodystrophy make you feel so tired?

Leukodystrophy: There is decline in general health of child, seizures, loss of vision/speech/hearing, loss or increase muscle tone, and slowing of mental/physical development. ...Read more

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I am always so tired could this be due to my disability I have leukodystrophy?

I am always so tired could this be due to my disability I have leukodystrophy?

Leukodystrophy: Unfortunately many brain and muscle diseases are associated with fatigue, either as a primary or secondary effect. Yours is one of them. Symptomatic treatments might be effective but potential side-effects may outweigh the benefits. Consult your neurologist. ...Read more

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Are there any homeopathic cure for leukodystrophy?

Simple answer - no: There's not a homeopathic cure for ANYTHING. That was easy.
The leukodystrophies are a sad group of conditions, and I certainly understand you grasping if a loved one of yours has it. "Lorenzo's oil" is being researched, but apparently doesn't show a huge amount of promise. Good luck to the patient. ...Read more

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Are there any possible treatments for leukodystrophy?

Are there any possible treatments for leukodystrophy?

Leukodystrophy Rx: Treatment
there is no cure for mld. Care focuses on treating the symptoms and preserving the patient's quality of life with physical and occupational therapy.

Research is studying techniques to replace the missing enzyme (arylsulfatase a).

http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002185/. ...Read more

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What is leukodystrophy?

What is leukodystrophy?

Childhood: This is a class of hereditary disorders affecting the white matter of the brain mainly presenting in childhood. The diseases may vary in extent and pace, but often affect walking, cognition, and may be associated with epilepsy. More information may be found on mayo clinic site or www. Aan. Com. ...Read more

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What are the tests for leukodystrophy?

Leukodystrophy tests: Neurodevelopmental tests demonstrate the following findings in patients with infantile or early juvenile metachromatic leukodystrophy:

•loss of previously achieved developmental milestones
•tremors
•truncal ataxia
•hyperreflexia progressing to hyporeflexia
hypotonia
gait abnormalities
•optic atrophy
neurocognitive tests demonstrate other abnormalities. ...Read more

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What exactly is aldrino leukodystrophy?

What exactly is aldrino leukodystrophy?

Genetic disorder: Adrenoleukodystrophy is genetic disorder that mainly affects males and results in the accumulation of very-long chain fatty acids in tissues throughout the body, mainly the central nervous system and the adrenal cortex, causing progressive neurodegenrative changes and adrenal insufficiency respectively. Prognosis not good unfortunately. ...Read more

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What are the symptoms of leukodystrophy?

What are the symptoms of leukodystrophy?

Leukodystrophy signs: gait disturbances
memory deficits
•seizures (may be present)
•loss of motor developmental milestones
•decreased attention span
•speech disturbances
•decline in school performance
the early juvenile form includes the following:

•gait disturbances
•tremors
•clumsiness
•loss of previously achieved skills
•intellectual decline
•behavioral changes
•seizures (possible)
the late juvenile and adult for. ...Read more

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Can you give some info on leukodystrophy?

Can you give some info on leukodystrophy?

LEUKODYSTROPHY: It is a group of disorders characterised by dysfunction of white matter of the brain. It is caused by imperfect growth of the myelin sheath, fatty covering that acts like an insulator around the nerve fiber.Each of the these are due to the defect in the gene that controls the production or metabolism of only one of the component molecule of myelin. These are inherited disorders, but may start spontane. ...Read more

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Can you tell me anything about the disability leukodystrophy?

Can you tell me anything about the disability leukodystrophy?

MLD: Is a lysosomal storage disease affecting myelin growth, the insulator of nerve fibers, affecting lipid metabolism. It leads to progressive dementia in adults from degeneration of white matter of brain. Also in young ones it causes muscle rigidity & hyper irritability & hyper sensitivity to environment, with loss of hearing & vision. ...Read more

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What is the treatment for leukodystrophy?

What is the treatment for leukodystrophy?

Leukodystrophy Rx: Treatment
there is no cure for mld. Care focuses on treating the symptoms and preserving the patient's quality of life with physical and occupational therapy.

Research is studying techniques to replace the missing enzyme (arylsulfatase a).

http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0002185/. ...Read more