Doctor insights on:
Metabolism Of Acetaminophen
Took about 5 pills of acetaminophen each 500mg. And smoked two cigarettes within an hour. Is that harmful?
Possibly!: Maximum Acetaminophen per 24 hour period should not exceed 3500-4000 mg. Long term excessive use may cause irreversable liver damage. Smoking cigarettes just not a good healthy thing to do, however, i see this as a personel choice. I would consider putting the cigarettes down and exercise every time you think a out smoking, that is how i kicked the habit 34 years ago! good luck. ...Read moreSee 2 more doctor answers
Safe amount of acetaminophen a day if I take a Trileptal 1200 mg/day a know inducer of CYP (increased toxic acetaminophen metabolite)?
Are there any p450 enzymes that act upon things like acetaminophen and nsaids? I'm really into pharmacology and pharmicokinetics.. And take them.
Yes: Cytochrome p450 metabolism accounts for about 5% of the breakdown of acetaminophen, and produces the toxic compound napqi that is responsible for its toxic effect on the liver. Nsaids are hydroxylated by 2c8 & 2c9 in the liver as one of several paths before conversion to the glucuronide & excretion in the urine. ...Read more
It depends: This is an important question. Too much Acetaminophen is dangerous. According to epocrates, a drug information program, most healthy adults can get up to about 1, 000 mg in 4 hrs, and 4, 000 mg (4 grams) per day safely. Children should get less, based on their age or weight. Read labels carefully, and ask your doctor or nurse if unsure. ...Read moreSee 1 more doctor answer
Don't do it again: This won't hurt or kill you, but you do need to show this helpful drug the respect it deserves. It's important to space the doses out so that you don't get sick. Up to 4000 mg/day is fine but you don't want to take even this much all at once -- you might overload the enzyme that processes it by the normal pathway. ...Read moreSee 1 more doctor answer
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