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It is vascular spasm in the fingers, toes, and can even involves the nose and ears and internal organs the blood vessels of the heart or kidneys in response to cold or stress causing the external elements especially the fingers, toes to turn white. Blue and red can also occur but I like to Emphasize if not white I can not be clear. Others ...Read more
MTX vs Humira (adalimumab): These drugs fight RA in completely different fashions. Mtx is the consensus first round choice of drugs to treat ra, both by the acr and eular (european version). Most, if not all, insurances require treatment failure with mtx before you start humira, (adalimumab) a much more expensive drug. In most cases, even if Humira (adalimumab) is started, patients will remain on mtx. ...Read more
Uncertain, but: It is known that celiac dz is associated w autoimmune diseases (antibodies against one's own tissues, eg diabetes-I).A letter in the Scandinavian Journal of Rheum in 2010 reported evidence of scleroderma-like activity in celiac disease. Raynaud's is found in cases of scleroderma, an auto-immune disease that causes scarring that can impede blood flow to fingers. 2010, Vol. 39, No. 5 , Pages 438-43 ...Read moreSee 1 more doctor answer
Gloves and. Meds!: Wearing gloves is essential in cold weather! an electric pocket warmer is useful! i favor the calcium channel blockers for use, but in lower doses, than treating bp! these drugs dilate arteries and prevent vasospasm with cold or anxiety quit well. I use Diltiazem the most in sustained release dosing only 1 x per/day. ...Read moreSee 1 more doctor answer
Many disorders can: Many disorders can cause raynaud's phenomenon. Examples include: scleroderma, lupus, rheumatoid arthritis, sjogren's syndrome, atherosclerosis, subclavian aneurysm, beta-blocker drugs, ergotamine-type drugs, hypothyroidism, reflex sympathetic dystrophy, magnesium deficiency, etc... ...Read moreSee 2 more doctor answers
It is magic?: 1the use of anti-malarials in autoimmune diseases was accidentally discovered in treating wwii vets for malaria. Those with RA improved. Chloroquine and ho-q were tested in sle, with very positive results. In the early 80's canadian researchers definitively showed fewer sle flares with ho-q. It is considered the rx of first choice for :sle. We now understand more of the mechanisms, but not all. ...Read more
Good medication: Recognizing that the disease is due to spasm of the muscle layer lining the arteries in response to temperature extremes, then using medications that reduce the spasm and promote dilatation would be most beneficial. There are excellent studies using a medication called Pletal (cilostazol) while i agree that there are systemic effects potentially, the benefits of this outweigh the risks. ...Read moreSee 1 more doctor answer
Different: Raynaud's is spasm of blood vessel with cold or stress leading to white (most important color change) as well as red and blue. Classicially it occurs in the fingers, but also can involve the feet or internal arteries. Livedo is a mottled reticulated vascular pattern that appears like a lace-like purplish discoloration of the lower extremities due swelling of medium veins. The causes can be many. ...Read more
Hashimotos. Ana + anti-ssa/ro. Stiff, painful, swollen joints + raynauds. Doc says it's "lupoid arthritis". Is this lupus? He gave me plaquenil (hydroxychloroquine) 200mg
Sounds consistent: The joint complaints and positive lab markers are consistent with lupus. The fact that raynaud's is present and you have an autoimmune thyroid condition help cinch the diagnosis of an autoimmune arthritis. In addition to standard treatments like Plaquenil (hydroxychloroquine) there are other interventions like diet and supplements to help decrease the dose of rx meds. A practitioner of integrative medicine can help. ...Read moreSee 2 more doctor answers
Yes: Over time, raynaud's symptoms in the fingers and toes will result in atrophy (shrinkage) of the skin, muscles, and whatever else is in the fingers and toes. The damage is due to lack of nutrients and lack of oxygen when the vasospasm occurs. In severe cases, gangrene (tissue death) of parts of the fingers and toes can occur. ...Read moreSee 1 more doctor answer
Early Ra. AntiCCP + 17. Other blood negative.
Doc1: MTX 7.5mg, Plaquenil 400mg, Celebrex (celecoxib).
Doc2: Plaquenil 200mg, Pred 5mg, Celebrex (celecoxib) .
Reasonable: You have the opportunity to do very well. Early RA responds better to any of the treatments compared to late RA (disease > 2 years). If you still have pain, stiffness, fatigue on this regimen, talk to your Rheumatologist about adding a biologic medication such as Enbrel, Humira or Remicade (infliximab). There are several others, but I usually start with one of these. Would help get rid of the prednisone. ...Read moreSee 1 more doctor answer
Many patients!: Results are very good, particulary when used alone and better with methotrexate. The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. A good choice for those who do not want to inject themselves sc. ...Read more