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Doctor insights on: Membranoproliferative Glomerulonephritis Mpgn

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Chronic glomerulonephritis pathophysiology?

Chronic glomerulonephritis pathophysiology?

Complex: Reduction in nephron mass from an injury reduces the gfr. This reduction causes hypertrophy & hyperfiltration of the remaining nephrons & to intraglomerular hypertension. These changes occur to increase the GFR of the remaining nephrons, thus minimizing the functional consequences of nephron loss. The changes are ultimately detrimental because they lead to glomerulosclerosis & further nephron loss. ...Read more

Dr. Patrick Sweet III
125 doctors shared insights

Glomerulonephritis (Definition)

A condition in which the kidney becomes acutely inflamed, typically caused by an abnormal ...Read more


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Is IGA Nephropathy genetic/hereditary?

Is IGA Nephropathy genetic/hereditary?

IgA neph: Data have shown a genetic clustering for IgA nephropathy - however its genetic nature is not certain - ...Read more

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How serious is membranous nephropathy?

How serious is membranous nephropathy?

Depends: Depends on severity, response to treatment, also underlying contributors such as lupus, hepatitis b or c, cancer or meds such as Penicillamine (not penicillin) or nsaids.Not all cases have an obvious contributor.Mild cases frequently go into remission without treatment.Severe or refractory cases may lead to dialysis or kidney transplant.A nephrologist can give a more specific answer case-by-case. ...Read more

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What is tubulointerstitial nephritis?

What is tubulointerstitial nephritis?

Interstitial nephrit: What is tubulointerstitial nephritis? ANS: Inflammation of the surrounding tissue of the tubules. Many causes. Too many to discuss here ...Read more

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With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?

SLE DPGN is bad.: The degree of remaining renal function dictates the inability of the kidney to excrete waste products and manage potassium levels. In any severe kidney disease when egfr approaches 15 ml/min uremia and elevated k+ levels are frequently noted. ...Read more

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Can nephritis or lupus nephritis be lethal?

Can nephritis or lupus nephritis be lethal?

Not dierectly: Any form of nephritis (meaning kidney inflammation) can lead to kidney failure which is usually not fatal since there are different forms of kidney replacement therapy (dialysis or transplantation). It would obviously be best to not reach this point and therefore prompt diagnosis and treatment would be recommended. ...Read more

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Cure of diffuse renal parenchymal disease?

Kidney: None, all you can do is protect the remaining portion of your kidneys under the care of a nephrologist. ...Read more

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Is autosomal recessive polycystic kidney disease very serious?

Is autosomal recessive polycystic kidney disease very serious?

It is different: It usually is more serious than the autosomal dominant disease since it needs inheritance from both parents to be expressed i.e. Both genes are affected. It accordingly gets expressed at an earlier age in life. The longer duration of polycystic disease is a factor in predicting dialysis need. ...Read more

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What is wegener's granulomatosis vasculitis?

What is wegener's granulomatosis vasculitis?

See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more

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How dangerous lupus nephritis?

How dangerous lupus nephritis?

Depends on biopsy: There are different grades of lupus nephritis based on the kidney biopsy. The more benign grades don't necessarily warrant any treatment but will needclose follow-up. The more severe forms (grade 4) require aggressive treatment with drugs to suppress the immune system since they may lead to kidney failure if left unchecked. If present, patients will also be treated for high blood pressure. ...Read more

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What is the rare renal disease called idiopathic collapsing glomeralpathy(icg)?

What is the rare renal disease called idiopathic collapsing glomeralpathy(icg)?

FSGS: Collapsing glomerulopathy is a variant of focal segmental glomerulosclerosis. In the past it was linked to HIV but there have been many cases in which the cause is unknown (hence it is termed idiopathic). ...Read more

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Please interpret pericardium tissue mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.

Please interpret pericardium tissue 
 mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles.  Hemosiderin-laden macrophages.

Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more

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What causes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)?

What causes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)?

The exact causes of GPA — formerly known as Wegener's granulomatosis — and MPA are unknown: GPA and MPA are both types of inflammation of the blood vessels (vasculitis). It is believed that one or more genetic and environmental factors, such as infections, allergic reactions, certain drugs and diseases, might trigger an abnormal immune system response that causes GPA and MPA symptoms. However, no specific infection or event has been identified as the cause. GPA and MPA develop when the immune system mistakenly identifies blood vessel cells as foreign invaders and attacks them. The vessels become inflamed, causing them to narrow or close off, disrupting the flow of blood to various organs and causing organ and tissue damage. No matter the cause, early diagnosis and treatment of GPA and MPA are essential for a full recovery. ...Read more

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Is proteinuria a kidney disease?

Is proteinuria a kidney disease?

No: You're simply leaking protein into your urine. The most common single cause is that a few percent of people do this just by standing up. It's easy to rule this in or out and your phyiscian will probably begin your workup this way. ...Read more

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What is kidney nephritis?

What is kidney nephritis?

Kidney inflammation: Nephros=kidney, -itis= an ending referring to inflammation. Nephritis just means the working cells/structure of the kidney are inflamed or irritated due to some event or infectious process. ...Read more

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