Doctor insights on:
Membranoproliferative Glomerulonephritis Mpgn
Complex: Reduction in nephron mass from an injury reduces the gfr. This reduction causes hypertrophy & hyperfiltration of the remaining nephrons & to intraglomerular hypertension. These changes occur to increase the GFR of the remaining nephrons, thus minimizing the functional consequences of nephron loss. The changes are ultimately detrimental because they lead to glomerulosclerosis & further nephron loss. ...Read more
Depends: Depends on severity, response to treatment, also underlying contributors such as lupus, hepatitis b or c, cancer or meds such as Penicillamine (not penicillin) or nsaids.Not all cases have an obvious contributor.Mild cases frequently go into remission without treatment.Severe or refractory cases may lead to dialysis or kidney transplant.A nephrologist can give a more specific answer case-by-case. ...Read moreSee 1 more doctor answer
Dyspneu, dm history, uremia, creatininemia, proteinuria, glucosuria, hematuria, nitrite (-), leucocyte esterase (+), bacteria (+). Diagnosis?
With acute diffuse proliferative glomerulonephritis caused by systemic lupus erythematosus, why would a patient have uremia and hyperkalemia?
Not dierectly: Any form of nephritis (meaning kidney inflammation) can lead to kidney failure which is usually not fatal since there are different forms of kidney replacement therapy (dialysis or transplantation). It would obviously be best to not reach this point and therefore prompt diagnosis and treatment would be recommended. ...Read more
Membranoproliferative glomerulonephritis caused by mixed cryoglobulinemia? Big words, little meaning. Plz explain.
Autoimmune : You may have an internal autoimmune process that needs treatment. ...Read more
It is different: It usually is more serious than the autosomal dominant disease since it needs inheritance from both parents to be expressed i.e. Both genes are affected. It accordingly gets expressed at an earlier age in life. The longer duration of polycystic disease is a factor in predicting dialysis need. ...Read moreSee 1 more doctor answer
See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more
Depends on biopsy: There are different grades of lupus nephritis based on the kidney biopsy. The more benign grades don't necessarily warrant any treatment but will needclose follow-up. The more severe forms (grade 4) require aggressive treatment with drugs to suppress the immune system since they may lead to kidney failure if left unchecked. If present, patients will also be treated for high blood pressure. ...Read more
Please interpret pericardium tissue
mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.
Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more
The exact causes of GPA — formerly known as Wegener's granulomatosis — and MPA are unknown: GPA and MPA are both types of inflammation of the blood vessels (vasculitis). It is believed that one or more genetic and environmental factors, such as infections, allergic reactions, certain drugs and diseases, might trigger an abnormal immune system response that causes GPA and MPA symptoms. However, no specific infection or event has been identified as the cause. GPA and MPA develop when the immune system mistakenly identifies blood vessel cells as foreign invaders and attacks them. The vessels become inflamed, causing them to narrow or close off, disrupting the flow of blood to various organs and causing organ and tissue damage. No matter the cause, early diagnosis and treatment of GPA and MPA are essential for a full recovery. ...Read more
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