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Doctor insights on: Melphalan Medication

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Can cancer cells become resistant to the damaging effects of melphalan?

Can cancer cells become resistant to the damaging effects of melphalan?

L-PAM or: Melphalan is l phenyalanine mustard, one of the oldest alkylating agents. Yes, resistance occurs. Also dns damage can be associated with leukemia. These agents are uncommonly used today, used to be the agent in breast cancer, now never used, and may still be used in blood/lymphatic malignancies. ...Read more

Dr. Morie Gertz
223 Doctors shared insights

Melphalan (Definition)

Melphalan is an aklylating agent which is a ...Read more


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How does melphalan kill cancer cells?

How does melphalan kill cancer cells?

Halt division: Melphalan or Alkeran (melphalan) is l phenylalanine mustard an alkylating agent acts on guanine based dna by halting cancer cell division. ...Read more

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Could you please describe two ways in which melphalan might kill cancer cells?

Could you please describe two ways in which melphalan might kill cancer cells?

Alkylating agent: Melphalan or Alkeran, (melphalan) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring and destroys DNA function of the cell. First recognized by Karnofsky when mustard gas used in World War I, mortality resulted from destroying WBC’s He helped develop nitrogen mustard as a chemotherapeutic agent ...Read more

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Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Interrupts DNA &RNA: Melphalan or Alkeran (melphalan) is nitrogen mustard derivative by alkalating n7 position of guanine interferes dna and ran synthesis in tumor cell, if the tumor is resistant to drug means tumor cell is repairing damage. ...Read more

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What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

Not able: For the most part the chemotherapeutic effects of many of the agents is to destroy the structure of the nuclear DNA. The Repairi mechanisms to allow cytotoxic repairs and as such preservation of tumor growth doesn't exist. Rather the malignant stem cells occupying a tumor do contain such enzymes and as such the stem cells are preserved and results in regowth of tumor. ...Read more

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Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Fever could be side: Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! Http://www. Livestrong. Com/article/36171-herbs-cancer/. ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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What is a "medication HA"?

What is a "medication HA"?

I think: Medication headache....a type of frequent or daily headache. I'm not positive though. Need to see what the context the phrase was used. ...Read more

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What is best pain medication?

What is best pain medication?

There are none...: Even the strongest opiates only "take the edge off" for people in chronic pain. Meds are only one part of dealing with the pain. A useful tool, but pain is so necessary for survival that we are not "allowed" to monkey with it much. In acute pain, the transition from miserable to less miserable can be great. In chronic pain, it's just part of the plan. ...Read more

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I need refills on my medications?

Not here: For that you will likely need the prime service of healthtap. Easier to call your pop imo ...Read more

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Are expired medications effective?

Sometimes: Sometimes they are. For the most part, expired drugs simply lose potency once past their expiration date. There are, however, some drugs that actually become harmful if taken after they expire. As such, it is best to throw out any medications you have after a year. ...Read more

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Which pain medication works better?

No answer: The best drug is the one that works with the lowest side effect incidence. That will change between patients. ...Read more

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Safest medication to take for pain?

ASPRIN: Actually no one has decided on 'safest'. Asprin has been around since before you were born and unless you take too much (yes, too much of anything isn't good) most people are okay with it. If the pain it too severe for asprin you need to know what causes it. Good diagnosis is called for. See the dr. ...Read more

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How can I dispose unused medications?

How can I dispose unused medications?

Several options: You can take them to your local pharmacy for proper disposal. Some medically oriented charities will also take medication for distribution to the disadvantaged. ...Read more

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Please describe the medication: topical?

Please describe the medication: topical?

Applies to skin: Topical just refers to how a medication is applied. In this case to the skin and is meant to treat local skin problems. Some meds are applied to the skin but are meant to be absorbed into the body in which case we use the term "transdermal" since it is meant to pass through the skin to affect the whole body. ...Read more

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What medications are given fordepression?

What medications are given fordepression?

Why R you depressed?: If your depression is affecting your life and/or those around you and you have trouble dealing with it or not knowing how to etc. It is very reasonable to seek help, either from a therapist, your physician/nurse, or both. Psychotherapy may be adequate for some, others may need both meds (many choices, depending on your symptoms/needs) and therapy. Consult doc. Good luck. ...Read more

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What medication is equivalent to covance d?

What medication is equivalent to covance d?

Yes: Covance d is a combination of losartan and hydrochlorthiazide- a diuretic). There are a number of such combinations for the treatment of hypertension. If this is a question of your co-pay, ask your physician about generic alternatives. ...Read more

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What pain medication can be taken for r.S.D.?

What pain medication can be taken for r.S.D.?

RSD, or: Complex regional pain syndrome can be difficult to treat and each patient needs to be treated differently. Opioid medications are definitely not the first option. Consider medications that affect nerve pain most, like neuromodulators such as gabapentin. Clonidine has been found to help some as well. Stellate ganglion blocks can be diagnostic/therapeutic. Consider topical ketamine creams as well. ...Read more

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What medication need to be taken for acidity?

What medication need to be taken for acidity?

Antacid: An h2 blocker (like Pepcid (famotidine) or its generic) once or twice daily, provides relief for many after about a week. If this fails, a proton pump inhibitor (ppi--like Prilosec or its generic) will often work where h2's have failed. If both fail after at least one week trial of each, see your dr or a GI dr for eval. ...Read more

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Would it be okay if I use hash as medication?

Would it be okay if I use hash as medication?

Condition?: There are some conditions that medical marijuana is helpful for. However there can be significant problems related to cannabis use. Thus, would only consider this when prescribed or directed by a physician who is knowledgable in this area. Take care. ...Read more

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I have rhititis. What medication shoud I take?

I have rhititis. What medication shoud I take?

Antihistamine: You can try an over the counter antihistamine to begin with. Would use one that is non drowsy. ...Read more

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The best medication for intertitial cysititis?

The best medication for intertitial cysititis?

Elimiron: Elmiron (pentosan) is a medication that is fda approved for ic (interstitial cystitis). The main way it works is not truly known, but it may help with coating the lining of the bladder. In ic, inflammation may be the main cause of pain. Have you seen a doctor in regards to this? Hopefully, you can get the proper testing and see if this med would work well for you. ...Read more

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What medications are best for managing my pain?

Depends - pain type: This depends on the diagnosis or type of pain you are experiencing. Consult with your physician or pain specialist to determine the right regimen. ...Read more

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Should I feel a particular way on add medication?

Should I feel a particular way on add medication?

Some people do: ADD medications, stimulants in particular may change the way you feel. Some feel calmer or less restless or agitated. Some feel more focused. Some feel increased restlessness. But in short, yes, stimulants can make you feel differently than prior to taking them. ...Read more

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Am I taking too much medication? What should I do?

Am I taking too much medication? What should I do?

Not enough info.: Recommend you go over your medication regimen (to include supplements, vitamins, herbs, prescription medications, over the counter medications, caffeine and alcohol use) with your physician. ...Read more

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What medications are recommended for drug addicts?

What medications are recommended for drug addicts?

Clarify, please!: Do you want to know how to treat addiction? There are many addicting drugs out there and the medical treatment is different for all of them. But for all of them Narcotics Anonymous or Alcoholics Anonymous are extremely helpful and can often be the only treatment required. Often these programs, which are free, have success rates equal to many inpatient and outpatient costly rehab programs. ...Read more

Dr. Stephen Scholand
4 Doctors shared insights

Alkeran (Definition)

Alkeran is an aklylating agent which is a ...Read more


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