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Doctor insights on: Melphalan

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Dr. Morie Gertz
223 Doctors shared insights

Melphalan (Overview)

Melphalan is an aklylating agent which is a kind of cancer drug.


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Can cancer cells become resistant to the damaging effects of melphalan?

Can cancer cells become resistant to the damaging effects of melphalan?

L-PAM or: Melphalan is l phenyalanine mustard, one of the oldest alkylating agents. Yes, resistance occurs. Also dns damage can be associated with leukemia. These agents are uncommonly used today, used to be the agent in breast cancer, now never used, and may still be used in blood/lymphatic malignancies. ...Read more

Dr. Morie Gertz
223 Doctors shared insights

Melphalan (Overview)

Melphalan is an aklylating agent which is a kind of cancer drug.


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Could you please describe two ways in which melphalan might kill cancer cells?

Could you please describe two ways in which melphalan might kill cancer cells?

Alkylating agent: Melphalan or Alkeran, (melphalan) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring and destroys DNA function of the cell. First recognized by Karnofsky when mustard gas used in World War I, mortality resulted from destroying WBC’s He helped develop nitrogen mustard as a chemotherapeutic agent ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Can cancer cells become resistant to the damaging effects of melphalan?

L-PAM or: Melphalan is l phenyalanine mustard, one of the oldest alkylating agents. Yes, resistance occurs. Also dns damage can be associated with leukemia. These agents are uncommonly used today, used to be the agent in breast cancer, now never used, and may still be used in blood/lymphatic malignancies. ...Read more

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How does melphalan kill cancer cells?

How does melphalan kill cancer cells?

Halt division: Melphalan or Alkeran (melphalan) is l phenylalanine mustard an alkylating agent acts on guanine based dna by halting cancer cell division. ...Read more

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Could you please describe two ways in which melphalan might kill cancer cells?

Alkylating agent: Melphalan or Alkeran, (melphalan) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring and destroys DNA function of the cell. First recognized by Karnofsky when mustard gas used in World War I, mortality resulted from destroying WBC’s He helped develop nitrogen mustard as a chemotherapeutic agent ...Read more

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Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Interrupts DNA &RNA: Melphalan or Alkeran (melphalan) is nitrogen mustard derivative by alkalating n7 position of guanine interferes dna and ran synthesis in tumor cell, if the tumor is resistant to drug means tumor cell is repairing damage. ...Read more

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What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

Not able: For the most part the chemotherapeutic effects of many of the agents is to destroy the structure of the nuclear DNA. The Repairi mechanisms to allow cytotoxic repairs and as such preservation of tumor growth doesn't exist. Rather the malignant stem cells occupying a tumor do contain such enzymes and as such the stem cells are preserved and results in regowth of tumor. ...Read more

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Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Mult. Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections. What causes fever?

Fever could be side: Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! Http://www. Livestrong. Com/article/36171-herbs-cancer/. ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Is this free?

Is this free?

Yes, this is free if: If you did not ask for premium, paid services, then this HealthTap BASIC is free. Post your question in English, with good grammar and spelling, and one or more of the thousands of volunteer doctors will answer it. They might skip repetitive questions, or ones that have too many abbreviations, or are otherwise hard to understand. (HealthTap's premium services include virtual medicine appointments) ...Read more

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Are you free?

Are you free?

Yes, this is free if: If you do not request premium, paid services, then this HealthTap BASIC is free. Post your question in English, with good grammar and spelling, and one or more of the thousands of volunteer doctors will answer it. They might skip repetitive questions, or ones that have too many abbreviations, or are otherwise hard to understand. (HealthTap's premium services are personal consultations for a fee.) ...Read more

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Who gets omg?

Who gets omg?

Can you clarify?: Omg is a texting-age expression "oh my god" but used even by secularists to express amazement and dismay at once. It's no medical acronym that I recognize though there are some trashy websites preseting medical freaks as having "omg disease". To which disease are you referring? Someone on healthtap will be happy to answer. ...Read more

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Is this live?

Yes and No: There are doctors on here all of the time. Your questions may get answered immediately or be answered later, depending on the expertise of the doctors online at the time and whether they see your question. ...Read more

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I got pleups?

Do you mean polyps?: Regular follow up with primary care doctor! ...Read more

Dr. M. Hytham Beck
4 Doctors shared insights

Alkeran (Definition)

Alkeran is an aklylating agent which is a ...Read more


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