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Doctor insights on: Melphalan

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Dr. Morie Gertz
223 doctors shared insights

Melphalan (Overview)

Melphalan is an aklylating agent which is a kind of cancer drug.


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Can cancer cells become resistant to the damaging effects of melphalan?

Can cancer cells become resistant to the damaging effects of melphalan?

L-PAM or: Melphalan is l phenyalanine mustard, one of the oldest alkylating agents. Yes, resistance occurs. Also dns damage can be associated with leukemia. These agents are uncommonly used today, used to be the agent in breast cancer, now never used, and may still be used in blood/lymphatic malignancies. ...Read more

Dr. Morie Gertz
223 doctors shared insights

Melphalan (Overview)

Melphalan is an aklylating agent which is a kind of cancer drug.


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Could you please describe two ways in which melphalan might kill cancer cells?

Could you please describe two ways in which melphalan might kill cancer cells?

Alkylating agent: Melphalan or Alkeran, (melphalan) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring and destroys DNA function of the cell. First recognized by Karnofsky when mustard gas used in World War I, mortality resulted from destroying WBC’s He helped develop nitrogen mustard as a chemotherapeutic agent ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Can cancer cells become resistant to the damaging effects of melphalan?

L-PAM or: Melphalan is l phenyalanine mustard, one of the oldest alkylating agents. Yes, resistance occurs. Also dns damage can be associated with leukemia. These agents are uncommonly used today, used to be the agent in breast cancer, now never used, and may still be used in blood/lymphatic malignancies. ...Read more

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How does melphalan kill cancer cells?

How does melphalan kill cancer cells?

Halt division: Melphalan or Alkeran (melphalan) is l phenylalanine mustard an alkylating agent acts on guanine based dna by halting cancer cell division. ...Read more

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Could you please describe two ways in which melphalan might kill cancer cells?

Alkylating agent: Melphalan or Alkeran, (melphalan) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring and destroys DNA function of the cell. First recognized by Karnofsky when mustard gas used in World War I, mortality resulted from destroying WBC’s He helped develop nitrogen mustard as a chemotherapeutic agent ...Read more

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Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Is it possible for cancer cells to repair the DNA damaging effects of melphalan?

Interrupts DNA &RNA: Melphalan or Alkeran (melphalan) is nitrogen mustard derivative by alkalating n7 position of guanine interferes dna and ran synthesis in tumor cell, if the tumor is resistant to drug means tumor cell is repairing damage. ...Read more

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What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

What are some ways that cancer cells could repair the DNA damaging effects of melphalan?

Not able: For the most part the chemotherapeutic effects of many of the agents is to destroy the structure of the nuclear DNA. The Repairi mechanisms to allow cytotoxic repairs and as such preservation of tumor growth doesn't exist. Rather the malignant stem cells occupying a tumor do contain such enzymes and as such the stem cells are preserved and results in regowth of tumor . ...Read more

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Mult.Myeloma relapsed after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections.What causes fever?

Mult.Myeloma relapsed  after treatment with velcade (bortezomib), (bortezomib) melphalan&dexamethasone. Melphalan stopped in dec, velcade (bortezomib) in april. Now takes carfilzomib& dexamethasone fever39.5. No infections.What causes fever?

Fever could be side : Effects of the chemotherapeutic agents and steroids considering there's no blood infection. Tylenol (acetaminophen) should help control the fever. Follow up with your oncologist. God bless you! http://www.Livestrong.Com/article/36171-herbs-cancer/. ...Read more

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The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician: The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. ...Read more

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Am I dying?

Am I dying?

We all are: A 3-word question with no details... well, life is short on Earth, regardless of whether a person lives 3 days, 3000 days, or 30,000 days. It is not length of one's life that matters, but the quality of the life lived. The goal is not to live a long life, but to live a good life. Even if a person makes it all the way to age 82, that's only 30,000 days. ...Read more

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I have cold?

I have cold?

Symptoms?: The most common symptoms of a cold are sneezing, running nose, congestion and scratchy throat. Additional symptoms can be coughing, headaches, mucus dripping down the back of the throat, loss of appetite and fever (in children). ...Read more

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What is asp?

What is asp?

In acupuncture an: Asp is an acupuncture semi-permanent needle. They are made in germany & come in stainless steel, gold, silver & titanium. They are used for auricular (ear) acupuncture. They are usually referred to as "asp's". ...Read more

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I have cold?

I have cold?

Cold: Tips: sore throat – gargle with warm salt water (1/2 tsp salt in 8 oz of water). Get strep test/culture if very sore. Congestion – saline nose drops or netti pot. For anti-inflammatory effect & mobilizing mucus- homemade chicken noodle soup. Hydrate- lots of water/clear broth/ add honey & a small amt. Of lemon juice to chamomile tea.. Fever/ pain – Acetaminophen / nsaid’s rest! ...Read more

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Pls help me?

Help: In order to assist you - you need to provide us with more information. Please re-ask and clarify the question that you need help with. Take care. ...Read more

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Am i dying ?

I don't know: I don't know, john. Technically, every person who is alive will die someday, yes. But unless you have been diagnosed with some untreatable illness, then no, you are not actively dying. If this is something you worry about a lot, mention it to one of your parents, a close adult friend, or a school counselor. A lot of people have these kinds of worries and you can get help to not worry so much. ...Read more

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Is it free ?

Is it free ?

Yes, this is free if: If you did not ask for premium, paid services, then this HealthTap BASIC is free. Post your question in English, with good grammar and spelling, and one or more of the thousands of volunteer doctors will answer it. They might skip repetitive questions, or ones that have too many abbreviations, or are otherwise hard to understand. (HealthTap's premium services include virtual medicine appointments) ...Read more

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I had some

What is ?: Please resubmit your question- not understood.

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Dr. Milton Alvis Jr
4 doctors shared insights

Alkeran (Definition)

Alkeran is an aklylating agent which is a ...Read more