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Doctor insights on: Melatonin And Klonopin Mixing

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I took 2 mg klonopin (clonazepam) and 18 mg of melatonin not knowing I wasn't supposed to mix the two. Is there a chance I won't wake up? I'm worried : (

I took 2 mg klonopin (clonazepam) and 18 mg of melatonin not knowing I wasn't supposed to mix the two. Is there a chance I won't wake up? I'm worried : (

Relax: Melatonin is extremely safe. Walter Pierpaoli, MD, PhD, is one of the leading melatonin researchers in the world. Dr. Pierpaoli says that "Melatonin is so safe you can take it by the pound." I would be more concerned about Klonopin (clonazepam). A recent report in the British Medical Journal reported that even short-term usage of the benzodiazepines greatly increased the risk of later Alzheimer's disease. ...Read more

Dr. Donald Jacobson
836 Doctors shared insights

Clonazepam (Definition)

Klonopin (clonazepam) belongs to a class of medications called benzodiazepines. They are also referred to as sedative-hypnotics & anxiolytics. These medications are used for a variety of indications to include anxiety, insomnia, muscle spasm, seizure, & alcohol withdrawal. All benzodiazepines including Clonazepam are potentially habit forming. Alcohol should be ...Read more


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I take 1 mg of Klonopin (clonazepam) and 50 mg of Topimax at night. Would it be ok to take a low dose (1-3mg) of melatonin?

Natural products: It would be perfectly OK, as melatonine is a natural product that helps your own similar substance work in sleep physiology and "bring down the curtains". It would also work better, if you keep your room dark when you take it. ...Read more

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Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Pretty safe.: That is the recommended dose for that vitamin D. There is not an obvious interaction between any of the drugs except for klonapin and melatonin (they both make one sleepy) and the interaction there is quite mild. Klonapin is a controlled dangerous substance with addictive potential. ...Read more

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Is it safe to take melatonin, valerian with my klonopin and seroquel (quetiapine)?

Sedatives. ..: Possibly safe. Whenever I'm asked about "natural" supplements (unless they're professional grade brands - such as Thorne) keep in mind that they're not usually tested for purity or potency. That said, melatonin can amplify the effects of quetiapine or clonazepam, but to what extent is unknown. Definitely discuss all of your OTC & Rx meds with your doctor - perhaps a dose change might help. G'Luck! ...Read more

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Can I take melatonin? I currently take neurontion 300 mg t.I.D., qd, klonopin 0.5 mg b.I.D., prn, Soma 350 mg h.S., tylenol (acetaminophen) qd

Can I take melatonin? I currently take neurontion 300 mg t.I.D., qd, klonopin 0.5 mg b.I.D., prn, Soma 350 mg h.S., tylenol (acetaminophen) qd

Yes, but: Higher doses of melatonin can actually interfere with normal sleep. Take 0.3 to 1 mg. 90 minutes before intended sleep and see how you do. There is a possible additive effect with your other meds that also can have sedative effects., . ...Read more

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What can I use for sleep after stopping trazodone? Previously on geodon, (ziprasidone) risperdal, klonopin, ativan, melatonin. At this point believe brain won't cbt

What can I use for sleep after stopping trazodone? Previously on geodon, (ziprasidone) risperdal, klonopin, ativan, melatonin. At this point believe brain won't cbt

Some alternatives: I don't understand the meaning of your last sentence; does it mean you have tried insomnia-directed cbt (as well as attention to sleep hygiene) but it hasn't worked? Sleep aids you didn't mentioned include rozerem, (ramelteon) doxepin, and various otc herbal mixtures. Also, withdrawal from some of the meds you mentioned could interfere with sleep. And, I'm assuming you aren't using alcohol in the evenings. ...Read more

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Can I take melatonin without any rysks? Does it have some colateral effects? Does it mix with a little dose of clonazepam? (0.3)?

Melatonin: Melatonin is very safe with very few interactions. If you look up the interaction in a pharmaceutical database, it reports increased sleepiness from the combination of melatonin and clonazepam, which is presumably what you want. ...Read more

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Would melatonin be a better substitute to consider for sleep instead of clonazepam. 5mg?

My opinion -: Yes. Would recommend sublingual or slow release melatonin as it can be broken down in the stomach. ...Read more

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I'm going to start a clonazepam taper. I take. 5mg in the morning and the same at night. What would be a starting dose of melatonin to use?

Melatonin 5mg: Melatonin is available over the counter in many different dosages. There is no standard dosage, however I usually recommend starting with 5mg for an adult dosage. You could go up to 10mg but above 10mg there is not usually much more benefit. I'm glad to hear that you are tapering the clonazepam. I'm always a fan of discontinuing regular use of it because it works best when taken only as needed ...Read more

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I have been taking 2 mg of clonazepam at night for years, and I'm weaning down to 1.5 now. Is it safe to introduce 1 mg melatonin at night with it?

Yes: Melatonin is a naturally occuring hormone produced by the pineal gland as it gets dark out, in order to prime us to sleep. Use of many medications, including benzodiazepines and alcohol, may impair our melatonin response. Doses from 1-3 mg are safe and effective, and actually may work better than higher doses (5-10 mg). I wean people by 0.25 decrements, rather than 0.5 though. ...Read more

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Am on both Lexapro (escitalopram) and clonazepam. Since the Lexapro (escitalopram) should be effective now, can melatonin be used to wean off of clonazepam?

Am on both Lexapro (escitalopram) and clonazepam. Since the Lexapro (escitalopram) should be effective now, can melatonin be used to wean off of clonazepam?

No: I would talk some more to physician about your plans before implementing them. My concern would be that melatonin would not do anything to prevent the potential seizures that could accompany the discontinuation of clonazepam. Your physician will hopefully guide you through the transition in a way that will minimize rhe risk of seizures. Stay safe! ...Read more

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Doctor prescribed clonazepam 1mg for anxiety and also told me to take 10mg of melatonin everynite before bed. Is this ok and or safe?

Doctor prescribed clonazepam 1mg for anxiety and also told me to take 10mg of melatonin everynite before bed. Is this ok and or safe?

10 mg Melatonin?: 1mg is a commonly used dose of clonazepam, and is often given at night. I agree with dr. Ali that you might not need both at the same time. The 10mg dose of melatonin seems very high. Physiologic doses of melatonin are around. 3mg -- and most adults take 1-3 mg when needed. Even rozerem, (ramelteon) a prescription melatonin receptor agonist, is dosed as 8mg. You might want to re-look at your 10mg dose. ...Read more

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Dr. Heidi Fowler
689 Doctors shared insights

Melatonin (Definition)

Melatonin_is a hormone that helps regulate sleep. Some studies suggest that there is abnormal melatonin production in children with autism and other developmental disorders. Several studies suggest that melatonin may be useful for improving sleep, if ...Read more


Dr. Donald Jacobson
821 Doctors shared insights

Klonopin (Definition)

Klonopin is a long-acting benzodiazepine which is a kind of sleep-inducing drug (anti-anxiety drug, psychiatric drug) and a blood pressure drug which is a ...Read more