Doctor insights on:
Melanoma Fact Sheet
My pathology report states junctional and lentiginous melanocytic nevus, extending to the peripheral edge. Is this melanoma?.
Mole, not cancer: Here is a translation of your path report: Junctional- location as it relates to depth in the skin, the junction between epidermis and dermis. lentiginous- means flat dark spot, melanocytic- made up of pigment cells (melanocytes), nevus - a lesion that contains nevus cells a type of melanocyte, aka "mole". This is a benign spot that appears to have been completely removed. Not a malignancy. ...Read more
Yes: All melanomas are considered malignant however they have different levels of metastatic potential. This means that some melanomas have the ability to spread to other parts of the body while others, especially in situ melanomas, have little or no risk of metastasis. ...Read moreSee 1 more doctor answer
Melanoma: Generally, a melanoma that has spread to another skin site resembles the primary lesion in that it is black and variegated in its depth of coloration. Sometimes, the metastatic lesion loses its color and appears flesh-colored. However, that is less common. Either way, the new lesion needs to be examined immediately. ...Read moreSee 1 more doctor answer
Metastasis: Stage IV (4) melanoma is the highest stage that a melanoma can reach. It is diagnosed by finding distant spread or metastasis to other parts of the body. Stage is different from clark's levels and breslow levels, although these can impact lower stages. (ajcc cancer staging manual, 7th ed., 2010). ...Read moreSee 3 more doctor answers
What is the likelihood of a dysplastic nevus turning into melanoma? I can't find any relative data online
Depends: It depends on several factors, like the total # of dysplastic nevi, nevi size, patient age, family history, etc. The reported annual transformation rate of any single mole into melanoma is ?1 in 200,000 in people 60. Check out this paper by Tsao H, et al, in Archives of Dermatology in 2003: The Transformation Rate of Moles (Melanocytic Nevi) Into Cutaneous Melanoma. ...Read more
Aggressive cancer: Melanoma develops from melanocytes cells of the lower layers in the skin. These cells produce pigments and the color of skin. When they form into cancer it can grow radially and deeply which can be dangerous as it can subsequently spread to other areas of the body. There are genetic predispositions as well as ultraviolet radiation exposure and sunburns are risk factors. ...Read moreSee 4 more doctor answers
Dysplastic nevus, or atypical moles, and they are benign lesions that resemble early melanoma, and about 1 in 10 million americans willmelanoma, what to do?
Watch carefully: Dysplastic nevi are potentially serious in that they can convert to infiltrating melanoma. In children with spitz nevus, they look malignant but never convert. In patients with neurofibromatosis there is a high incidence of dysplastic nevi and since many are present they are watched for changes in shape, darkening in color or redness around the lesion suggesting that they are converting. ...Read more
If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?
Treatment: Does not alter biologic behavior. Mets are never good. Some argue to re-biopsy to recheck re-ceptors (er, pr her-2-neu): the cells that metastasize may be different from those at outset. Best gauge is time from DX to relapse for "slow". Bony only and er+ usually fit this pattern. Cytotoxic chemo does not change growth or met potential, but cancers themselves can mutate to more aggressive type. ...Read moreSee 1 more doctor answer
Also called by its: Generic name, vinorelbine, it is a mitotic spindle inhibitor, and the new "v" drug added in the 1990's. It enjoys a prominent role in nsclc lung cancer treatment in canada and some european countires (france, italy), but not used commonly in us. Now Pemetrexed dominant in most adenocarcinoma, free-for all in squamous. Data using nav in post op (anita trial) reliable. Paclitaxel dominant usa. ...Read moreSee 1 more doctor answer
I read something on the information sheet that said "meningococcal (type c) conjugate vaccine" what does that mean?
Way vaccine made.: This refers to how the vaccine is made. The meningococcal conjugate vaccines are made by chemically linking the capsular polysaccharide antigens individually to a protein. The vaccines do not contain live bacteria.Meningococcal conjugate vaccines are believed to give better protection and are more effective in young children than the original polysaccharide vaccine. ...Read more
Does a completely removed potential precursor to malignant melanoma atypical nevus return in same place? Does it return as a malignant melanoma?
No: If it was removed completely, it will not return. This is why it's good to take margins. If it does recur at the site, it will probably still be a benign lesion, but keep an eye on it. The most important thing about a diagnosis of atypical nevus is that it warns you're likely to get a melanoma someplace else. Keep an eye on all your skin (partner, dermatologist) and quick removal will save you! ...Read moreSee 1 more doctor answer
Possible: Most of the skin metastasis in local area of breast as set lite metastasis in advanced breast cancer, out side breast skin metastasis is rare and unusual. Primary skin cancers like melanoma from pig. Mole or squamous cell, or basal cell all have their own futures, for any suspicious, non healing lesion should seek help of a professionals for early detection and cure. ...Read moreSee 2 more doctor answers
There's so much tv advertising about atrial fibrillation. John's Hopkins publishes that AF is found in about 1% of the general population. Maybe true?
Hyperplastic squamous epithelium in a verrucous pattern of growth, is this bad? At places they show features of nuclear atypia. Whats your view?
This kind of lesion: may be 'pre-cancerous" Get it removed....(you probably just did ..right??) Hope this helps! Dr Z ...Read more