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Doctor insights on: Melanoma Fact Sheet

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My pathology report states junctional and lentiginous melanocytic nevus, extending to the peripheral edge. Is this melanoma?.

My pathology report states junctional and lentiginous melanocytic nevus, extending to the peripheral edge.  Is this melanoma?.

Mole, not cancer: Here is a translation of your path report: Junctional- location as it relates to depth in the skin, the junction between epidermis and dermis. lentiginous- means flat dark spot, melanocytic- made up of pigment cells (melanocytes), nevus - a lesion that contains nevus cells a type of melanocyte, aka "mole". This is a benign spot that appears to have been completely removed. Not a malignancy. ...Read more

Dr. Mike Bowman
961 doctors shared insights

Skin Cancer (Definition)

A condition in which some element of your skin which is one of the most complex organs in the body, degenerates into cancer, with the cancerous (malignant) cells growing ...Read more


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Is ocular melanoma the same as skin melanoma?

Is ocular melanoma the same as skin melanoma?

Not really: Ocular melanoma starts in the back of the eye and is genetically and clinically different than the more common skin melanoma. Although they look fairly similar under the microscope, their typical clinical patterns are very different. ...Read more

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What are the criteria for determining malignancy in melanoma? Aren't all melanoma malignant?

What are the criteria for determining malignancy in melanoma?  Aren't all melanoma malignant?

Yes: All melanomas are considered malignant however they have different levels of metastatic potential. This means that some melanomas have the ability to spread to other parts of the body while others, especially in situ melanomas, have little or no risk of metastasis. ...Read more

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Is it common to put oneself at risk for malignant melanoma of the skin?

Is it common to put oneself at risk for malignant melanoma of the skin?

Yes: Most skin cancers are related to excess sun exposure. Fortunately, despite how often we suffer significant sun damage, melanoma is uncommon. ...Read more

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Does melanoma that has spread to a distant skin site look like a melanoma?

Does melanoma that has spread to a distant skin site look like a melanoma?

Melanoma: Generally, a melanoma that has spread to another skin site resembles the primary lesion in that it is black and variegated in its depth of coloration. Sometimes, the metastatic lesion loses its color and appears flesh-colored. However, that is less common. Either way, the new lesion needs to be examined immediately. ...Read more

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What constitutes stage 4 melanoma on a superficial mole that has gone malignant?

What constitutes stage 4 melanoma on a superficial mole that has gone malignant?

Metastasis: Stage IV (4) melanoma is the highest stage that a melanoma can reach. It is diagnosed by finding distant spread or metastasis to other parts of the body. Stage is different from clark's levels and breslow levels, although these can impact lower stages. (ajcc cancer staging manual, 7th ed., 2010). ...Read more

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What is the likelihood of a dysplastic nevus turning into melanoma? I can't find any relative data online

Depends: It depends on several factors, like the total # of dysplastic nevi, nevi size, patient age, family history, etc. The reported annual transformation rate of any single mole into melanoma is ?1 in 200,000 in people 60. Check out this paper by Tsao H, et al, in Archives of Dermatology in 2003: The Transformation Rate of Moles (Melanocytic Nevi) Into Cutaneous Melanoma. ...Read more

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Why does breast cancer get more publicity? Is it the numbers or the komen foundation?

Why does breast cancer get more publicity? Is it the numbers or the komen foundation?

All: Early diagnosis is important for cure, great organisations like american cancer society, komen foundation etc with programs that constantly help the public awareness of the disease , provide the funds for research with final aim the cure. ...Read more

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What is melanoma skin cancer?

Aggressive cancer: Melanoma develops from melanocytes cells of the lower layers in the skin. These cells produce pigments and the color of skin. When they form into cancer it can grow radially and deeply which can be dangerous as it can subsequently spread to other areas of the body. There are genetic predispositions as well as ultraviolet radiation exposure and sunburns are risk factors. ...Read more

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Dysplastic nevus, or atypical moles, and they are benign lesions that resemble early melanoma, and about 1 in 10 million americans willmelanoma, what to do?

Watch carefully: Dysplastic nevi are potentially serious in that they can convert to infiltrating melanoma. In children with spitz nevus, they look malignant but never convert. In patients with neurofibromatosis there is a high incidence of dysplastic nevi and since many are present they are watched for changes in shape, darkening in color or redness around the lesion suggesting that they are converting. ...Read more

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If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?

If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?

Treatment: Does not alter biologic behavior. Mets are never good. Some argue to re-biopsy to recheck re-ceptors (er, pr her-2-neu): the cells that metastasize may be different from those at outset. Best gauge is time from DX to relapse for "slow". Bony only and er+ usually fit this pattern. Cytotoxic chemo does not change growth or met potential, but cancers themselves can mutate to more aggressive type. ...Read more

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With cancer patients, is navelbine (vinorelbine) something that kills cancer cells?

With cancer patients, is navelbine (vinorelbine) something that kills cancer cells?

Also called by its: Generic name, vinorelbine, it is a mitotic spindle inhibitor, and the new "v" drug added in the 1990's. It enjoys a prominent role in nsclc lung cancer treatment in canada and some european countires (france, italy), but not used commonly in us. Now Pemetrexed dominant in most adenocarcinoma, free-for all in squamous. Data using nav in post op (anita trial) reliable. Paclitaxel dominant usa. ...Read more

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I read something on the information sheet that said "meningococcal (type c) conjugate vaccine" what does that mean?

I read something on the information sheet that said "meningococcal (type c) conjugate vaccine" what does that mean?

Way vaccine made.: This refers to how the vaccine is made. The meningococcal conjugate vaccines are made by chemically linking the capsular polysaccharide antigens individually to a protein. The vaccines do not contain live bacteria.Meningococcal conjugate vaccines are believed to give better protection and are more effective in young children than the original polysaccharide vaccine. ...Read more

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Does a completely removed potential precursor to malignant melanoma atypical nevus return in same place? Does it return as a malignant melanoma?

Does a completely removed potential precursor to malignant melanoma atypical nevus return in same place? Does it return as a malignant melanoma?

No: If it was removed completely, it will not return. This is why it's good to take margins. If it does recur at the site, it will probably still be a benign lesion, but keep an eye on it. The most important thing about a diagnosis of atypical nevus is that it warns you're likely to get a melanoma someplace else. Keep an eye on all your skin (partner, dermatologist) and quick removal will save you! ...Read more

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Is it common that breast cancer metastisize in the skin? What are signs of skin cancer?

Is it common that breast cancer metastisize in the skin? What are signs of skin cancer?

Possible: Most of the skin metastasis in local area of breast as set lite metastasis in advanced breast cancer, out side breast skin metastasis is rare and unusual. Primary skin cancers like melanoma from pig. Mole or squamous cell, or basal cell all have their own futures, for any suspicious, non healing lesion should seek help of a professionals for early detection and cure. ...Read more

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Movies: does the cancer that joseph gordon-leavitt get in 50/50 exist?

Movies: does the cancer that joseph gordon-leavitt get in 50/50 exist?

Only a story: It is only a story, some one with 50/50 chance of survival , life and drama around that person , adam lerner character is fiction, possible to have such disease. ...Read more

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There's so much tv advertising about atrial fibrillation. John's Hopkins publishes that AF is found in about 1% of the general population. Maybe true?

There's so much tv advertising about atrial fibrillation. John's Hopkins publishes that AF is found in about 1% of the general population. Maybe true?

7-20% chance of afib: results from population studies vary a bit, but one i keep in mind is : 1% of 40 year olds have afib 2% of 50 yo 3% of 60 yo 7% of 70 yo 20% of 80 year olds have afib ...Read more

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Does it ever happen that a squamous cell skin cancer grow under skin without any sign?

Does it ever happen that a squamous cell skin cancer grow under skin without any sign?

Usually not. : However some skin cancer can look like moles or other common growths. It is best to be checked by your doctor or dermatologist once a year. More frequently if you have a history of skin cancer or it runs in the family. ...Read more

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Dr. Travis Kidner
2,631 doctors shared insights

Melanoma (Definition)

A type of cancer that develops from pigment-containing ...Read more