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Doctor insights on: Melanoma And Enbrel

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Is it safe for a pt with history of basal cell carcinoma and squamous cell carcinoma (father died of malignant melanoma and sister has had a melanoma removed) to take enbrel (etanercept) for ra? Red hair, blue eyes.

Is it safe for a pt with history of basal cell carcinoma and squamous cell carcinoma (father died of malignant melanoma and sister has had a melanoma removed) to take enbrel (etanercept) for ra? Red hair, blue eyes.

Immunosuppressant: Enbrel (etanercept) is an immunosupressant to minimize yuur bodies attack of itself. Anything that lowers your immune system may increase your risk for certain cancers such as lymphoma, basal and squamous cell cancers, particularly if you are already fair skinned. Good sun block, wide brimmed hats, minimize sun exposure, etc. Your doctor should be able to discuss the relative risks of treatment of enbrel (etanercept). ...Read more

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Dr. Mike Bowman
960 doctors shared insights

Skin Cancer (Definition)

A condition in which some element of your skin which is one of the most complex organs in the body, degenerates into cancer, with the cancerous (malignant) cells growing ...Read more


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How many documented melanoma deaths with patients on enbrel (etanercept)?

How many documented melanoma deaths with patients on enbrel (etanercept)?

Not knowable: I appreciate your concern, but this is the kind of data that can't be obtained by any means. Enbrel (etanercept) is an immunomodulator that may suppress the immune response which has a small impact on melanoma progress; it's also given for psoriasis in which the skin cancer risk is already up. It's worth the risk; do keep a close eye on your skin so that skin cancers get rx'd early & there' s no risk of death. ...Read more

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Is there a difference in humira and enbrel (etanercept) treatment of psoriasis?

Is there a difference in humira and enbrel (etanercept) treatment of psoriasis?

No great...: No great differences. Enbrel (etanercept) is once weekly and Humira is once every two weeks. They have similar efficacy in large trials, but differences exist between individuals! both should be tried only after Methotrexate therapy has failed! ...Read more

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What's more effective for pustular psoriasis, methotrexate or enbrel (etanercept)?

What's more effective for pustular psoriasis, methotrexate or enbrel (etanercept)?

Both: Both can be effective, personally i feel Enbrel (etanercept) is safer. There are other options. Talk it over with your dermatologist. ...Read more

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Melanoma and lupus related?

Melanoma and lupus related?

Autoimmune,malignanc: Malignant melanoma is a malignant skin cancer that can metastasize. It is seen in pigmented skin lesions. Lupus is an abnormal body response that forms antibodies that can harm vital organs and skin. ...Read more

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Daughter on methotrexate and enbrel and indocin for JRA but hates getting shots every week. Could remicade (infliximab) be a better choice?

Daughter on methotrexate and enbrel and indocin for JRA but hates getting shots every week. Could remicade (infliximab) be a better choice?

An alternative: It is an alternative. However, it still requires being stuck for an IV every 4-8 weeks and sitting in an infusion chair for 2 hours. ...Read more

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My child has JRA and failed merhotrexate alone, Enbrel and now highest remicade (infliximab) isn't controlling it anymore so what are orher possible meds?

My child has JRA and failed merhotrexate alone, Enbrel and now highest remicade (infliximab) isn't controlling it anymore so what are orher possible meds?

See details: That question needs to be directed to the child's rheumatologist and not someone over the internet who has no history and cannot examine the child. ...Read more

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Currently taking humira (adalimumab) for crohns. diagnosed with dvt after foot fracture and prescribed xarelto. aren't there bleeding risks with humira (adalimumab) injections?

Currently taking humira (adalimumab) for crohns. diagnosed with dvt after foot fracture and prescribed xarelto. aren't there bleeding risks with humira (adalimumab) injections?

Localized: Bleeding at injection site aka bruising may occur. It may ooze at the injection site. Benefits of anticoagulation clearly out weighs any risk. Any bleeding at the injection site would be minimal. ...Read more

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If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?

If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?

Treatment: Does not alter biologic behavior. Mets are never good. Some argue to re-biopsy to recheck re-ceptors (er, pr her-2-neu): the cells that metastasize may be different from those at outset. Best gauge is time from DX to relapse for "slow". Bony only and er+ usually fit this pattern. Cytotoxic chemo does not change growth or met potential, but cancers themselves can mutate to more aggressive type. ...Read more

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RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?

RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?

RA + psoriasis: There are a number of newer medications that could help you. Xeljanz works by disrupting cytokine and growth factor signaling pathways. A trial of the medication is useful to see whether it helps you. Other medications that might help include Remicade (infliximab) and Apremilast ...Read more

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When would a doctor use remicade (infliximab) when treating jra ? Currently on methotrexate , enbrel, indocin , and now. 3 weeks of steroids

Any time: It is always an option if your current meds are no longer effective. Sometimes changing from Enbrel to Remicade (infliximab) yields a better response as one can adjust the Remicade (infliximab) dose to a particular situation. ...Read more

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Am i at a higher risk for melanoma due to basal cell skin cancer?

Am i at a higher risk for melanoma due to basal cell skin cancer?

Yes: Basal cell carcinoma is one o the most common malignancy in the us. Risk factors include uv radiation from sun exposure. This also increases your risk of melanoma. Make sure to get regular full body examinations from your dermatologist so any suspicious lesion can be caught early and biopsied. ...Read more

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I have Crohn's disease & take cimzia (certolizumab pegol) injectables. It isnt taking care of all my symptoms. Is there another class of drug I can add with the cimzia (certolizumab pegol)?

I have Crohn's disease & take cimzia (certolizumab pegol) injectables. It isnt taking care of all my symptoms. Is there another class of drug I can add with the cimzia (certolizumab pegol)?

6MP , MTX: The medications that can be used with Cimzia (certolizumab pegol) most commonly include 6mp - azathiorine or Methotrexate (in addition to Mesalamine / steroids). Natalizumab is an other biologic that can be used in those where anti-tnfs (like cimzia) fail, but they are not used together. ...Read more

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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Dr. Robert Lowe
125 doctors shared insights

Etanercept (Definition)

Etanercept is an immune system suppressor which is a kind of ...Read more


Dr. Robert Lowe
143 doctors shared insights

Enbrel (Definition)

Enbrel is an immune system suppressor which is a kind of ...Read more