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Doctor insights on: Megace Progestin Based Agent

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Dr. George Canellos
58 doctors shared insights

Megestrol (Definition)

Megestrol is a progestin-based agent which is a kind of women's ...Read more


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Prempro (conjugated estrogens and medroxyprogesterone) works well but expensive. What is exact alternative?

Prempro (conjugated estrogens and medroxyprogesterone) works well but expensive. What is exact alternative?

Options: There are options. Prempro has different dosages of estrogen and Progesterone component. Estrogen (estradiol) comes in 0.3mg, 0.45mg, and 0.625mg. The Medroxyprogesterone acetate comes as 1.5mg 2.5mg and 5mg. As your dosage of estrogen goes up, so does progesterone. You can take estrogen as pill or patch. I like the patch. And then take Provera (medroxyprogesterone) for Progesterone (2.5 or 5.0mg). ...Read more

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Which is better: crinone (progesterone gel) or standard progesterone suppositories?

Which is better: crinone (progesterone gel) or standard progesterone suppositories?

Crinone (progesterone gel).: Crinone (progesterone gel) is a more absorbable formulation of vaginal Progesterone and approved to prevent preterm birth in women with very short cervix (<15-20 mm) by transvaginal prenatal ultrasound. Suppositories are not approved for that indication! use Crinone (progesterone gel) 8% (90 mg per 1.125g) nightly until 37 weeks if your physician agrees. ...Read more

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Hydroxyprogesterone hexanoate is androgen precursor with elimination half-life 7.8 d,for an injection 5ml of 250 mg/mL what is such androgenic effect?

Hydroxyprogesterone hexanoate is androgen precursor with elimination half-life 7.8 d,for an  injection 5ml of 250 mg/mL what is such androgenic effect?

A Hairy Proposition: In women, excess amounts of androgens can cause such "virilizing" effects as acne, hirsutism (excess hair growth in "inappropriate" places, like the chin or upper lip) and thinning hair. Long-time use is associated with serious health consequences, such as insulin resistance and diabetes, high cholesterol, high blood pressure and heart disease. It all sounds like lots of fun, doesn't it? ...Read more

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Estrogen supplements vs. Birth control? Which is safer?

Estrogen supplements vs. Birth control? Which is safer?

Neither: They both contain estrogen. Both have pros/cons and potential adverse side effects. It depends upon the situation and you need to discuss it w/your doc. ...Read more

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When adding estrogen to prometrium (micronized progesterone) for perimenopausal relief how is amt. Determined?

When adding estrogen to prometrium (micronized progesterone) for perimenopausal relief how is amt. Determined?

Starting dose: Most people will use 1-2 mg which are the lowest doses for effectiveness, sometime we go higher if symptoms are persistant. ...Read more

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Which among drospirenone containing ocp or cyproterone acetate is more effective in lowering male hormones?

Drospirinone : Drospirinone has more anti-testosterone effects than other types of progesterone. All progesterones will lower circulating testosterone. This particular Progesterone also competes with testosterone at the receptor level. This gives it a dual effect. ...Read more

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Hormone replacement- is the dose and duration of prometrium (micronized progesterone) used in menopause dependent on the dose of estrogen being used by the patient.?

Hormone replacement-  is the dose and duration of prometrium (micronized progesterone) used in menopause dependent on the dose of estrogen being used by the patient.?

Not necessarily: If you still have a uterus, then you need a combination of estrogen and progesterone. The Progesterone can by taken continuously or in a cyclic fashion. Remember, you are only using the minimum dose of hormones to treat the symptoms that are bothering you. Discuss these doses with your doctor. ...Read more

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Which synthetic estrogen is safest, Estradiol Valerate, Mestranol, or Ethinyl Estradiol?

Which synthetic estrogen is safest, Estradiol Valerate, Mestranol, or Ethinyl Estradiol?

Synthetic meds: 1st no such thing as free lunch ie there's always some potential risk or side effect. 2nd FDA only approves meds which they deem benefit greater than risk (tho obviously not w/o disagreement & controversy). 3rd no studies demonstrate benefit of any oral estrogen over another tho some studies suggest topical safe than oral. 4th Natural isn't safe than synthetic ie tobacco is natural but isn't safe! ...Read more

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I can't take estrogen due to suspected migraines. Which progestin is safest for me, norethindrone, levonorgestrel, or etonogestrel?

I can't take estrogen due to suspected migraines. Which progestin is safest for me, norethindrone, levonorgestrel, or etonogestrel?

Not enough: information. This is something you need to discuss with your doctor, including whether there is an indication to begin progesterone. ...Read more

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49yr f - alora patch (.05) & prometrium (micronized progesterone) (100mg) bleed& clots by 5 days on meds. Prob hormonal imbalance. How to balance? More estr or prometrium (micronized progesterone) ?

49yr f  -  alora  patch (.05) & prometrium (micronized progesterone) (100mg) bleed& clots by 5 days on meds. Prob hormonal imbalance. How to balance? More estr or prometrium (micronized progesterone) ?

Prob. less estrogen: Estrogen causes the lining of the uterus to thicken and later this causes the bleeding. You probably need less estrogen and possible more Progesterone depending on other symptoms. See your doctor to get adjusted. ...Read more

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What is the standard starting dose of progesterone bioidentical hormone cream?

What is the standard starting dose of progesterone bioidentical hormone cream?

See below: Knowing your present level help direct treatment...Saliva testing can help tell you what is out of balance. This tells you how much free hormone is available, and then with the help of some one experienced in natural hormone therapy many corrections can be corrected. ...Read more

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When prometrium (micronized progesterone) stimulates instead of sedates a perimenopausal woman what should be taken? Estrogen in combo with prometrium (micronized progesterone)?

When prometrium (micronized progesterone) stimulates instead of sedates a perimenopausal woman what should be taken? Estrogen in combo with prometrium (micronized progesterone)?

Go see your doctor: While our impression of estrogen for perimenopausal women has changed dramatically over the last decade, it still should be used for right reason, and sedation is not one of them. So go see your prescribing doctor & tell her/him about your side effects so that s/he can offer you some alternatives (rather than just throw more medications at you). ...Read more

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Is it true a topical estrogen & progesterone are better than pill form? If so, which topical estrogen & progesterone do you favor?

Topical E has benefi: Estrgen topically avoids the pill relaterd passage through the liver and is therefore likely less risky. With progeterone the data are uncertain. My favored estrogen is eva mist. I would still use Progesterone by mouth (prometrium). ...Read more

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Can Cellulose Microcrystalline as an inactive ingredient in carb blocker pills decrease the effectiveness of Yaz birth controll pills?

Can Cellulose Microcrystalline as an inactive ingredient in carb blocker pills decrease the effectiveness of Yaz birth controll pills?

No effect: Cellulose microcrystalilne is inert meaning it has no effect on the body. It is the binder for pills. There will be no effect on Yaz birth control pills. However carb blocker pills do not work. Save your money. ...Read more

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Outside of compounded estrogens, is estrasorb the only topical estrogen for hormone regulation, not vaginal issues. ?

Outside of compounded estrogens, is estrasorb the only topical estrogen for hormone regulation, not vaginal issues. ?

No: There are various patches. Vivelle (estradiol) is the most commonly used. I like vivelle (estradiol) because it comes in various doses that allows for very selective titration of dose. ...Read more

Dr. Howard Schneider
42 doctors shared insights

Megace (Definition)

Megace is a progestin-based agent which is a kind of women's ...Read more