Doctor insights on:
Medicine For Supranuclear Palsy
...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more
Gaze palsy: Meaning, one can't look to the right or left. ...Read more
Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read moreSee 1 more doctor answer
Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read moreSee 2 more doctor answers
Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more
Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more
Read on: PSP ( Steel Richardson Syndrome) is a progressive degenerative condition in the involuntary movement disorder genre. See a neurologist specialist in this type of illness. There is no cure (as in most conditions!) and the treatment not ideal Your doctor will tell you how to cope with it and will give palliative treatment ...Read more
Good Rx available!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read moreSee 2 more doctor answers
Speech therapy task: Persons with neurologocal disorders of swallowing may benefit from assessment and treatment by a speech therapist whois trained in swallowing disorder therapy. This would include persons with a condition like 'progressive' supranuclear palsy. ...Read moreSee 1 more doctor answer
PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read moreSee 1 more doctor answer
You cannot: Psp is progressive supranuclear palsy in the group of parkinsonism plus=no response to treatment with Dopamine it is thought to be genetic and cause degeneration and changes in the neurotransmiters in basal ganglia and other locations in brain--less understood compare to parkinson disease. ...Read moreSee 1 more doctor answer
Unlikely: Though anesthetics do have an effect on the brain, it is unlikely that they would cause this problem. The anesthetics that we use can decrease blood flow to certain areas of the brain, so they might unmask a pre-existing psp, but again that is speculation. I would talk to your neurologist about this problem. ...Read moreSee 1 more doctor answer
No effective therapy: ...Has been proven. Look at this article - http://emedicine.Medscape.Com/article/1151430-treatment i assume there has been a thorough neurologic work-up and trial of a Dopamine agonist. There are some treatments in this article to consider with some benefit by case report. ...Read moreSee 1 more doctor answer
I was diagnosed with progressive supranuclear palsy 5 years ago. Are there any good clinical trials available for psp?
Try this: Psp is frustrating and unfortnately progressive. Also, there just aren't many doctors with a ton of experience with this "rare" condition. See: http://www.Pspinformation.Com/ you may be able to find what you are looking for, or at least get connected to a support network. ...Read moreSee 1 more doctor answer
I have progressive supranuclear palsy. My biggest issue is that my eyelids are hard to open (90% of the time). Are there any good solutions for this?
Some to try...: Visual problems are common complaints with psp. Sometimes this is due to spasms of the muscles causing the eyes to stay closed. Other times the eyes involuntarily point down or don't line up together. Treatment is difficult, but options for are available to try. See http://www.Pspinformation.Com/disease/psp/psp-eyesight.Shtml. ...Read moreSee 1 more doctor answer
Parkinson's Disease: Progressive supracuclear palsy is a severe form of parkinsonism. It is characterized by no or minimal response to levodopa, prominent subcortical cognitive impairment, severe balance disorder, axial dystonias, and the classical inability to voluntarily move eyes in vertical plane. In contrast, idiopathic parkinson's disease commonly has better response to levodopa, resting tremors, slower decline. ...Read moreSee 2 more doctor answers
Good thots, but: At this time, there is NO cure for progressive supra nuclear palsy (AKA, Steele, Richardson, Olezewski Syndrome). It seems a variant of Parkinson's but does not respond to the usual Parkinson's meds. Much ongoing research may provide breakthroughs, and if you have it or know someone who does, find a nearby Movement Disorder Specialist who has research. ...Read more
What are some alternate treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
PSP: With any of these other forms of medicine, you would need very skilled, experienced professionals to work with you alongside your conventional neurologist. Many conventional physicians are becoming trained in ayurveda and homeopathy -- i'm sorry, but i know little about siddha although this one originated in india like ayurveda. For homeopathic physicians, you can see: http://tinyurl.Com/lgsovco. ...Read more
Can you suggest any alternative treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
Stem cells : This is a neurologic condition which has no real cure. I currently am implanting stem cells for patients with this condition, into the CSF. These are autologous cells from your own fat. IRB-approved patient-funded study. Contact 949-642-6787 for more details. Make sure you have a second opinion on the diagnosis. ...Read more
What are some alternative treatments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
Collaborative care: Psp is a rare degenerative disease of the brain involving movement & balance as well as changes in mood, behavior and personality. Conventional medicine has no cure. Homeopathy does not treat the specific pathological condition, but can help the person by applying the single homeopathic medicine called for by his/her specific experience. You need a very well-trained homeopath to work with you. ...Read more
Different types: Supranuclear refers to loss of function due to a lack of high level cerebral control of a cranial nerve. E.G., in supranuclear gaze paresis there is difficulty voluntarily moving the eyes, but reflex eye movements are intact. Nuclear/ infranuclear refers to problems caused by damage to a cranial nerve nucleus or nerve itself. In this case voluntary & reflex movements would be impaired. ...Read more
The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available. ...Read moreSee 1 more doctor answer
Multidisciplinary: While there is no single effective medication to stop the progression of psp; some short term modest benefit has been shown with bromocriptine for the rigidity, Botox for dystonia and sialorrhea, methylcellulose for dry eyes, and cognitive stimulation/physical exercise for cognitive function and gait and balance training. ...Read more
A 45 year old patient got fascial palsy ,she was given drugs with no benefit ,its going for three month didn't get any better,what can be done ?thnx
Confusing question: CP is a stable defect in movement and posture related to an injury to the nervous system that occurred in the first 3 years of life. There is no "medicine" to treat CP, but a patient with the disorder may have a variety of related problems (seizures, excess salivation,etc) that might benefit from medication. ...Read moreSee 2 more doctor answers
I was diagnose with bells palsy 3 days ago my doctor told me it was a little bit t late to get treated but i dont understand mine medicine is only20mg?
Bells Palsy: Bells palsy is only a diagnosis of exclusion, not a primary diagnosis especially if its the first time happening. 3 days is still early enough to begin treatment if other pathologies are sufficiently excluded to make idiopathic facial Nerve inflammation and compression the likely diagnosis. The starting Prednisone dose should be at least 60 mg for 3 days followed by taper to be effective. See ENT. ...Read more
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