Doctor insights on:
Medicine For Sickle Cell Disease
Could: Cold meds with stimulants like psuedophedrine can raise the heart rate and blood pressure. Sickle cell pts don't do well under stress conditions and this could cause an undue stress on those pts sensitve to these meds. Would stick with chlorocedin-hbp wich is a decongest med without the stimulation side effect. Its over the counter and has a pic of a heart on label. ...Read more
I have sickle cell disease and I get diluade for pain push through the IV and I started getting bad tooth pain after I get my medicine do you know y?
Need to see the: Tooth. I would suggest seeing a dentist to evaluate the tooth. ...Read more
What can thin blood aside from prescription medicine? My husband has a clotting disorder that drs can't diagnose. They have tested for all of the factors, sickle cell, etc... No diagnosis. He was on Coumadin (25 mgs/day) & his level went from. 9 to 1.
Difficult issue: A dose of 25 mg of Coumadin (warfarin) is way more than what is effective in most people. It is not uncommon to not be able to find the cause of clotting disorders. There are other anti-cogulants on the market, however given the difficulty in managing your husband's clotting disorder, he may require evaluation and management by a hematologist specializing in coagulation disorders. ...Read more
Not much: Sickle cell disease is seldom subtle. Patients have intermittent periods of intense pain, often in bone, they have all manifestations of profound anemia, including diminished exercise tolerance, shortness of air, generalized fatigue, etc. This is a very bad disease with few subtle manifestations. ...Read more
Yes: The defect of sickle cell anemia occurs when 2 sickle cell genes are passed to a newborn. Since each parent passes half their genes at conception & it takes 2 sickle genes to cause disease, one gene comes from each parent. Many parents carry this gene quietly, unknown to them because it doesn't make a single gene carrier sick. ...Read more
Genetics: Sickle cell disease must be inherited from both parents. Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything. ...Read more
My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?
25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read more
Is it possible to be diagnosed with sickle cell anemia at 43? Even without ever experiencing any symptoms of the disease?
Possible, but...: Most people will have symptoms of enough severity to be diagnosed before adulthood. That being said, there is variation in the severity of sickle cell disease, most likely due to a number of other genes that modulate the symptoms. Thus, it probable is quite rare, but there could be that individual with a particular genetic makeup that has minimal disease that goes undiagnosed. ...Read more
Both carriers of sickle cell anemia. What can you tell them about their chances of any child of theirs exhibiting this disease?
If my boyfriend has sickle cell anemia and I don't have neither the trait or disease, will our child end up having it?
No: If your boyfriend has sickle cell anemia (2 abnormal genes) and you have 2 normal genes, then your children will all have sickle cell trait but none will have the disease. You need to be sure you have no other blood abnormalities like thalassemia or hemoglobin c trait which can be totally asymptomatic; this would change the answer significantly! ...Read more
Does sickle cell nemia has treatment? If so what are the medications? What are the foods that achild with sickle cell anemia eat? Is it tur that when some body reaches the age eighteen the disease disapears
Many questions: Sickle cell anemia is genetic and never disappears without bone marrow transplantation. Sickle cell anemia has medications that improve outcomes. Penicillin prophylaxis, empiric treatment of fever with antibiotics, and Prevnar (pneumococcal vaccine) / Pneumovax immunizations decrease risk of dying from infection. Hydroxyurea can decrease the frequency of painful crises and may minimize / delay sickle cell damage to body ...Read more
Agree with Dr Diede: Sickle-cell trait & disease is an autosomal recessive inheritance from parents (genetics). Malaria is a parasitic infection. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life." ...Read more
My boyfriend & I have sickle cell anemia, our son will also inherit the disease. Should we wait until umbilical cord stops pulsating before clamping?
Doesn't matter: Sickle cell disease will affect his blood cells over time as they sickle with dehydration and illness, or as they live a shorter duration in the body. Generally there aren't any symptoms at birth, and nothing having to do with the cord will make a difference. In actuality, his fetal hemoglobin will be more protective from sickle cell, and treatments now focus on keeping fetal hemoglobin around. ...Read more
Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production. The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood. The blood cell then becomes distorted in the small capillaries and the spleen. The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more
Check with Heme Dr.: Hematology doctors who takes care of the sickle problems have guidelines on cold medications that are ok to use. Some doctors recommend not using tylenol/motrin/advil to treat fever, because such meds may "mask" a fever that would otherwise send a patient to the doctor to get treatment for an infection. Some recommend avoiding meds that can increase heart rate (such as phenylephrine and sudafed). ...Read more
I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more
No: Sickle cell anemia is a genetic condition where the hemoglobin made for red cells is defective. There is no cure other than a bone marrow transplant, if the patient could tolerate this risky procedure. Acupuncture may prove a benefit in handling some of the pain episodes, but it will not change the genes. ...Read more
If you suffer from a chronic pain disorder such as sickle cell anemia what natural pain relief is there?
Blood: The genetic defect is in the hemoglobin molecule. ...Read more
Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more
Abnormal blood cells: Sickle cell disease occurs when there is an abnormal type of hemoglobin in blood cells. Thought to be a survivor advantage against malaria, when these cells have too little oxygen they collapse and get stuck in small vessels. This cuts off the blood supply to organs and causes severe pain. Sickle cell traits is when only half the genes code for the abnormal hemoglobin, usually not symptomatic. ...Read more
Red blood disorder: Autosomal recessive disorder when rbc's become rigid and cannot carry oxygen. The hemoglobin is abnormal. Also know as hbss vs hbas or trait. With low oxygen tension the beta chain of the hemoglobin molecule cannot carry oxygen properly and takes a different form-becomes sickle shaped, inelastic. They cannot pass through capillaries and lead to occlusion and ischemia. Rx transfusions, fluids. ...Read more
Sickle cell trait: If you only have 1 of the two genes for sickle cell disease, you have sickle cell trait. This is a benign finding with no real symptoms. It's main significance is that you can pass this gene on to your children. If your partner also has sickle cell trait, then there is a probability that a child in the next gen will have sickle cell disease. ...Read more
Inheritance: The sickle cell gene is a mutation in the way the hemoglobin molecule is formed. It takes a pair of sickle genes to cause the change. A single normal gene can cancel the abnormal gene effect. Parents with a single sickle cell gene will be asymptomatic. When a baby gets a sickle gene from both parents, the abnormal genes are expressed as SS disease. ...Read more
Dominant genetically: Sickle cell disease is inherited as an autosomal recessive condition, which is what you will read from online sources and textbooks. One must inherit the gene from both parents to have the disease. This assumes that inheriting one copy of the gene (trait patient) has no phenotype (medical problems). This is not exactly true, as athletes have died from trait under extreme conditions. ...Read more
Impossible to say: Without knowing anything about you, I can't say how likely. Any symptoms previously or family history? If not, much less likely. Ancestors from africa or around the mediterranean? If not, much less likely. Were you born in a state after they had required screening for sickle cell? If yes and your parents were notified that your screen was normal then you don't. I can't help much more than that. ...Read more
Many ways.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and other problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more