Doctor insights on:
Medicine For Renal Cell
Hi this nagarjun this is wrt my dear friend anupam who is fighting with renal cell carcinoma in advanced stage. No medicine is working. Please help.
I'm so sorry: The best drugs for metastatic renal cell carcinoma are pazopanib, axitinib, sorafenib, and sunitinib. If these aren't working, then a clinical trial might be an option. But it sounds like your friend might die, and may already know that deep down. You can help by comforting, listening, and facing this together. It is a profound gift to be with someone at death, just like at birth. Be at peace. ...Read more
Yes: It's not common. If it does appear, it raises suspicion for a hereditary predisposition (von hippel — lindau, others). There are a few pediatric kidney cancers that mimic common renal cell carcinoma clinically but are distinct pathologic entities. ...Read more
Varies with stage: Fortunately many renal cell carcinomas are now being diagnosed at an early stage (when the tumor is small and doesn't invade any other structures) thanks to improvements in imaging (ct scan etc). If early stage, many patients do very well after the tumor is removed. However, as the stage of the tumor increases, the risk of the cancer behaving aggressively increases. So stage helps to predict. ...Read more
Get a good md: Find a doctor you can trust. Get a second opinion if you feel the need to either confirm the treatment course or find a different path. Consider removal of tumor in kidney if possible. Treat sites of metastatic disease aggressively if possible. ...Read more
Treat or observe: Renal carcinoma is a primarily surgical disease. Most patients likely benefit from excision of tumors with the option of partial kidney removal allowing preservation of renal function compared to total removal. Newer options for small tumors include thermal ablation where cold or heat destroys the tumor. In some patients with small tumors and poor health or old age, surveillance can be pursued. ...Read more
CT scan w. contrast: (iv contrast). Renal ultrasound will also demonstrate kidney tumors but not nearly the detail of ultrasound. Ultimate test is microscopic pathalogical examination of tumor after it has been removed. Good luck. ...Read more
Most likely Stage I: All tumors are staged by the tumor, nodes, metastasis (staging system). Stage i kidney tumors are less than 7 CM in size and have no evidence of lymph node as well as distant metastasis. Stage ii tumors are larger than 7 CM and have no lymph node or distant metastasis. Stage iii tumors are locally advanced. Stage IV tumors have spread to lymph nodes or other organs. ...Read more
Hematuria,pain,mass.: This cancer presents with a classic triad of hematuria, flank pain, and a flank mass, but in only about 10-20% of patients. The most common individual symptoms are hematuria (40%), flank pain (40%), palpable mass (33%), and weight loss (33%). Symptoms like erythrocytosis (3%), hypercalcemia (5%), and non-metastatic hepatic dysfunction (15%) can also occur. ...Read more
?egfr??: Please avoid using abbreviations...they may have different meaning to different folks. Is this epidermal growth factor receptor(EGFR) that you are talking about? Or is this something related to GFR(glomerular filtration rate) which is a test for Kidney function???. Please clarify so that we can address your question properly. ...Read more
Is polycythemia the cause of renal cell carcinoma or renalcell carcinoma the cause of polycythemia?
Polycythemia: Polycythemia is not the cause of renal cell carcinoma. ...Read more
Unusual but possible: Metastasis (spread) to the skin is uncommon for renal cell carcinoma. Lung is a much moe common site of spread. However, skin metastasis has been described. In fact, there are patients who were originally diagnosed solely through the biopsy of a suspicious skin lesion. Fortunately, unusual skin lesions are often accessible for biopsy which should decrease the uncertainty of diagnosis. ...Read more
Poor: Unfortunately even with chemo, stage IV renal cell has a short survival time. Some reasonably good chemo agents are coming available but present therapies may work for a while, then quit working. ...Read more
Not clear cut:
There is no special test that is an early sensitive indicator. The current guidelines after removal of a kidney tumor is exam, ldh and other blood test and ct scan.
In many tumors we have found that routine testing is not a great help.
A key idea is that any symptoms that is new or worrisome should be investigated quickly. Target the test to the symptom. ...Read more
It varies: Renal cell carcinoma (rcc) unfortunately is usually asymptomatic until it's advanced stage. If it causes symptoms, it may present as blood in the urine, flank pain. If it spreads to other organs, it can cause problems in those areas including bone pain, shortness or breath, fatigue. Not uncommonly, rcc is picked up incidentally on ct scan of the abdomen but there is no role for ct screening. ...Read more
Why do you ask?: Little renal cell carcinomas are a fairly common incidental finding at autopsy and we have no idea how long they've been there. If one is symptomatic, there's no guessing survival time. In any decision about accepting treatment, an honest discussion about both length and quality of life is essential. ...Read more
Possibly curable: Sunitinib, a new multitargeted tyrosine-kinase inhibitor (TKI), has shown high activity in patients with metastatic renal cell carcinoma (mRCC) and has demonstrated improvement in survival of those patients with metastatic disease. Sunitinib inhibits the vascular endothelial growth factor (VEGF) receptor and other tyrosine kinases, including the platelet-derived growth factor (PDGF) and c-kit receptor at nanomolar concentrations. ...Read more
My brother has ust been diagnosed with renal cell carcinoma are my sister and I likely to get it too?
Unlikely: Few reported cases of familial renal cell carcinoma. Hope this helps. ...Read more
Is it true that renal cell carcinoma rarely spreads when the growth is less than 3cm in size? Has it ever happened or is it just not as likely?
Should i be nervous that they found a 7cm. Or 7mm something around my left kidney? I have has renal cell carisoma stage 2 years ago they did a parti
Worry won't help: 7mm and 7cm are hugely different--which is it? These bumps can be normal anatomy, cysts, abscess or tumors. If you are concerned, seek a biopsy from your physician to alleviate or confirm your suspicions and provide a diagnosis. With a positive history, you are right to be concerned, but not complacent. Worry will not change any outcome! ...Read more
What is renal cell adenocarcinoma it was on my daughters death cerificate after she died in a car wreck along with multiple blunt force injuries i understand that part
Here's what happened: It's fairly common for an adult who died unexpectedly in an accident to have something serious that was not known in life. I list all cancers that I find in accident victims on the death certificate, simply so the family will know and for the sake of public health records. I'm going to assume you didn't know the cancer was hiding in the kidney and that it was asymptomatic. I'm sorry about ur loss. ...Read more
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