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Medicine For Paroxysmal Nocturnal Hemoglobinuria
Blood test and hx: Most important is the history of blood in the morning on urination for no apparent reason. Other causes of blood in urine must be ruled out. Sometimes blood may be so small or dilute that urine is not red but may just appear dark. A family history or relative with PNH is also helpful but not necessary. Finally a blood test that will test for PNH must be abnormal. Is there a concern for PNH? ...Read more
No easy fix: Anyone telling you otherwise is deceiving you. This is a lifelong health problem though the severity between cases is widely variable. Your physician will guide you if you need transfusion, anticoagulation and/or eculizumab. ...Read more
Not always: You may not even have abnormally-colored urine in the mornings. Or you may develop anemia or have deep vein thrombi and their complications. If you have pnh, this is a management problem for you with your hematologist, and you'll do best to learn as much as you can about it. ...Read more
Do you know if there are any experts who have treated more than 1 patient with paroxymal cold hemoglobinuria? I
PCH~: A: millions. Just Google (or look up in the Medical Section of your local phone directory) any "hematologist" or in the USA (Heme-Onc) doc, of any worth and reknown and go see him. This is not esoterica, my dear ! ...Read more
Hemoglobinuria: "Haemoglobinuria is one of the manifestations of severe malaria and results from severe intravascular haemolysis. Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been implicated in its aetiology. Haemoglobinuria may be associated with severe anaemia and, less frequently, acute renal failure." See: http://www.malariajournal.com/content/11/1/336 ...Read more
Differences: Myoglobinuira (m) is the result of the muscle break down, due to trauma, where myglobin in the muscle is found in the urine. Hemoglobinuria is a condition in which hemoglobin is found in abnormally high concentrations in the urine. The condition is often associated with hemolytic anemia. Excess hemoglobin is filtered by the kidneys, which excrete it into the urine. ...Read more
People with thalassemia or hemolytic anemia, why they present usually with hemoglobinuria ? Inspite they have reduced rbcs !
Hemoglobinuria....: Is simply the presence of hemoglobin in the urine, and can be seen in any condition that results in intravascular hemolysis. It is not a specific finding. Indeed it can be seen in thalassemias, where red cells are more prone to oxidant stress and mechanical disruption. There many intrinsic and extrinsic reasons for hemolysis to occur. Hope this helps. ...Read moreSee 1 more doctor answer
I have paroxysmal a fib and I am 70 years old, i only have short episodes 4 hours once in 2 weeks average .Do i need to take rate control drugs?
What surgical or alternative (not drugs) treatments are available for chronic paroxysmal hemicrania?
Waking up breathless once every week or two. Not sure whats wrong. How often is shortness of breath seen in patients with paroxysmal nocturnal dyspnea?
Which drug has less proarythmic effect,less negative inotropic effect , more effective for paroxysmal Afib cordarone (amiodarone) or flecanide?
What is the antiarrythmic drug of choice for paroxysmal Afib started before 1yr in 72yr male hypertensive with mild left ventricular hyper trophy ?
A-fib drugs: There are options for treating atrial fibrillation. 1) Use beta blockers &/or calcium blockers to control the heart rate, but this does not prevent a-fib episodes. 2) Anti-arrhythmic drugs vary in effectiveness and side effects: amiodarone, sotalol, flecainide, and dofetilide are used. 3) An ablation procedure is another strategy. Get a consult on HealthTap to look at your particular case! ...Read more
What combination antihypertensive drugs to use to achieve target Bp in patient with ckd(no ptn Uria )and paroxysmal a fib ?
My father 72yr with hypertension paroxysmal Af with s.cr1.65 on metoprolol ER100and cordarone (amiodarone) 200 1*3 for wk is there drug better than cordarone (amiodarone) forhm?
Paroxysmal Af : first thing to know is treatment for PAF can be rhythm control or rate control. Depending on access to care and expertise in your area, cure can achieved from AF by ablation of the focus of arrhythmia and then hopefully need no medicine. Wean off. Alternately if on metoprolol and cordarone (amiodarone) (need to also watch thyroid on this medicine, lung toxicity), also should be on blood thinner to mitigate cva ...Read more
What is your opinion about drug(moxonidil0.2)for hypertensive 72male with paroxysmal Afib on betaloc amlodipine and cordarone (amiodarone) the doc put him on it?
Hypertension: In my opinion there are better choices than minoxidil such as a diuretic like hydrochlorothiazide, or an ace inhibitor like lisinopril or an arb like cozaar (losartan) or avapro. Of course his physician or cardiologist, who knows his condition and laboratory values, is better qualified to recommend treatment. ...Read more
Malaria: The malaria parasite infects red blood cells (rbc's) where it goes through several multiplication stages. The rbc eventually ruptures, releasing the parasites and haemoglobin. The haemoglobin is filtered by the kidney and is excreted into the urine. Each new parasite then goes on to infect another rbc and the cycle is repeated. ...Read more
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