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Doctor insights on: Medicine For Myeloproliferative Disorders

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What are the real symptoms of myeloproliferative disorders?

What are the real symptoms of myeloproliferative disorders?

Varaible: There are 3 main types- essential thrombocytosis (et), polycythemia vera (pv) and myelofibrosis (mf). In et, there is increased clotting and risk for strokes. In pv, there is generalized itchiness, ruddy face, and stroke risk. In mf, patients get low blood counts over time causing fatigue, large spleen, poor appetite, abdomen pain, transfusion need. ...Read more

Dr. Robert Hawley
186 Doctors shared insights

Myeloproliferative Disorders (Definition)

You may consult this site for info on this ...Read more


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How do you know who is most likely to get myeloproliferative disorders?

How do you know who is most likely to get myeloproliferative disorders?

Not able to know: We do not know who is most likely to develop a myeloproliferative disorder. It is, however, a disease that increases in incidence with age. ...Read more

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What is the definition or description of: Myeloproliferative disorders?

See below: You may consult this site for info on this topic: http://www. Umm. Edu/health/medical/altmed/condition/myeloproliferative-disorders ...Read more

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Can myeloproliferative disorder be diagnosed by an mri?

Can myeloproliferative disorder be diagnosed by an mri?

Myeloid and: Lymphoid refer to blood and marrow elements. Mri cannot greatly help, but can show marrow signal abnormalities. A bone marrow follows evaluation of a smear to discern type and yes no to leukemia, imaging not in the line up unless symptom point to a bone, . ...Read more

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What blood tests would indicate a Myeloproliferative disorder?

What blood tests would indicate a Myeloproliferative disorder?

Abnormal (high) blood: This disorder is suspected in individuals who have a very high WBC count (Like in CML) and also has a genetic abnormality (Philadelphia Chromosome present). Other patients have Myelofibrosis where there is a very big enlargement of the spleen. Occasionally it is just very platelet count (Essential Thrombocythemia (ET) ...Read more

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What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder?

What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder?

Need close follow-up: The specificity of the jak2 v617f pcr test for the diagnosis of myelpproliferative disorder is very high, near 100%. After excluding sample mix-up, any patient with a positive jak2 mutation should be carefully followed for the development of polycythemia vera, myelofibrosis, or essential throbocythemia. ...Read more

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What does myeloproliferative disorder with essential thrombocythemia mean?

What does myeloproliferative disorder with essential thrombocythemia mean?

Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more

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What is a myeloproliferative disorder that includes essential thrombocythemia?

What is a myeloproliferative disorder that includes essential thrombocythemia?

Too many platelets: Myeloproliferative disorders are a set of marrow malignancies characterized by excessive production of certain types of blood cells. Essential thrombocytopenia is one of them, in which marrow makes too many platelets. There are well-tolerated oral agents which help. Other myelodysplastic syndromes are polycythemia vera and chronic myelogenous leukemia. ...Read more

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Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder?

Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder?

Spectrum of disease: Myelodyaplastic syndrome is a type of myeloproliferative disorder. So it's one disease but there is a spectrum. Myelodyaplasia means abnormal looking blood cells seen in your blood or in the bone marrow. This is usually due to an underlying bone marrow issue like infection or a possible bone marrow cancer and a bone marrow biopsy could be warranted at this point. Talk to your doctor. Take care. ...Read more

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Hi my mother had myeloproliferative disorder or syndrome & a dr. Tod me I will eventually turn into leukemia. It doesn't have to turn into l. Rt?

Hi my mother had myeloproliferative disorder or syndrome & a dr. Tod me I will eventually turn into leukemia. It doesn't have to turn into l. Rt?

Correct: The myeloproliferative disorders are polycythemia vera, essential thrombocythemia, and myelofibrosis. Of these three, only myelofibrosis is known to progress to leukemia, and only rarely.
Did you mis-hear and the diagnosis is actually myelodysplastic syndrome? Perhaps, since myelodysplastic syndrome can turn into leukemia. Perhaps double-check and ask which kind of mpd she has. ...Read more

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If a 91 year old has an acute transformation of his myeloproliferative disorder & is treated then would the treatment normally be given an in ICU?

If a 91 year old has an acute transformation of his myeloproliferative disorder & is treated then would the treatment normally be given an in ICU?

Depends: Doctors usually recommend treatment based on the patients needs. ICU ensures close monitoring and fast response to any sign of major complication. For a 91 y/o it depends on his overall health status, prognosis and the extent of treatment elected by patient or his proxy. ...Read more

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In general, if a 91 yr-old has acute transformation of a myeloproliferative disorder then is it worthwhile to treat the pt, if there is a treatment?

It depends: It depends on the Diagnosis of the new transformations (there are multiple ways transformation occurs...so tell us what is the new diagnosis and we can guide you further. ...Read more

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Are there any treatments for acute transformation of overlap myelodysplascity/myeloproliferative disorder in an elderly patient If so, what are they?

Are there any treatments for acute transformation of overlap myelodysplascity/myeloproliferative disorder in an elderly patient If so, what are they?

Try hypomethylating: CMML is common form of overlap syndrome, can be treated with hypomethylating agent (VADAZA) as MDS. Efficay? If acute transformation to acute leukemia (AML), then should treat leukemia. If pt is older and not a candidate for intense induction, hypomethylating is also an option. For other acute transformation, treat them accordingly. Sometime, just supportive care or clinical trial consideration. ...Read more

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Is there a medical definition of "immuncompromised"? Would someone with a neutrophil count of 14.1 x10^9 or myeloproliferative disorder qualify?

Is there a medical definition of "immuncompromised"? Would someone with a neutrophil count of 14.1 x10^9 or myeloproliferative disorder qualify?

Yes: Immunocompromised means that you have an impaired immune system but the impairment may be different from one individual to another. People with myeloproliferative disorder can indeed be immune- compromised due to diminished and/or defective number of immune cells (mostly lymphocytes) produced. Low but not high neutrophils also increases the risk to get seriously ill from even minor infections. ...Read more

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Infection makes it harder to recover from an acute transformation of a myeloproliferative disorder But can the antibiotics also have an adverse effect?

Infection makes it harder to recover from an acute transformation of a myeloproliferative disorder But can the antibiotics also have an adverse effect?

Yes, but necessary: Myeloproliferative disorders, especially if transforming, are associated with increased risk of serious infections because the cells do a poor job doing what they are supposed to. Antibiotics to treat infection, especially sepsis, are lifesaving. However, antibiotics can also cause side effects, such as rashes, nausea, and diarrhea, that are unpleasant. Talk to your doctor about your symptoms ...Read more

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Is it safe to have cosmetic filler like botera if you have chronic myeloproliferative disorder. This is a bone marrow disorder?

Is it safe to have cosmetic filler like botera if you have chronic myeloproliferative disorder. This is a bone marrow disorder?

Probably safe: Most dermal fillers are non allergenic and are inert. They should not react or have problems with medical issues. They are also inject superficially and not internally. ...Read more

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Is it unusual (even if possible) for overlap myeloproliferative-myelodysplastic disorder to lower an elderly person's oral temperature below 36C for about 50% of his temp readings over 2 weeks? The temperatures are highly likely to be accurate.

Is it unusual (even if possible) for overlap myeloproliferative-myelodysplastic disorder to lower an elderly person's oral temperature below 36C for about 50% of his temp readings over 2 weeks? The temperatures are highly likely to be accurate.

Can be normal: You don't need anything at all to see this is older folks. Trusting they are not hypothyroid, but if they are getting around okay, I would draw no conclusion. Different folks have different baselines and some older folks normally run a bit cooler ...Read more

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The question is not about me I understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder But what is a blastic transformation of the disorder? Is it the same thing as an ac?

Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing. ...Read more

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IF overlap myeloproliferative/myelodysplasticity disorder is cause of suspected pneumonia what changes to path results expected other than CRP & WBC?

IF overlap myeloproliferative/myelodysplasticity disorder is cause of suspected pneumonia what changes to path results expected other than CRP & WBC?

Reviewing a case: These little text boxes are not enough to review a complex case. You might consider having a consult with a physician here on HealthTap. ...Read more

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Can hypothermia in an elderly pt be a symptom of an acute transformation of overlap myeloproliferative/myelodysplacticty disorder? Pt has hi WBC & CRP

Can hypothermia in an elderly pt be a symptom of an acute transformation of overlap myeloproliferative/myelodysplacticty disorder? Pt has hi WBC & CRP

Hypothermia/mds: Elderly often feel cooler than younger individuals. Hypothermia (how low?) may be a sign of infection /sepsis just like high fever. If one has myelodysplastic syndrome, would check for UTI, a common cause of infection, subtle pneumonia.Also check thyroid, adrenal function. Elevated WBC is a concern for sepsis and transformation. Go to the ER for blood cultures and evaluation. ...Read more

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I had a bone marrow bx to rule out a myeloproliferative illness. The pathologist recommends a trephine core biopsy. What reason would that before?

I had a bone marrow bx to rule out a myeloproliferative illness. The pathologist recommends a trephine core biopsy. What reason would that before?

Two kinds of bone ma: There are two different ways to get a sample of the bone marrow. One is called bone marrow aspirate and the other one is called bone marrow biopsy (trephine). It seems that they may have done just a aspiration of the bone marrow initially. Biopsy is essential in some conditions like you might have and not required in others like in acute leukemia. ...Read more

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What problems can I expect with myloproliferative disorder?

What problems can I expect with myloproliferative disorder?

It depends: On the subtype. You may experience risk for both clotting and excess bleeding. You may have itching night sweats or abdominal discomfort and poor appetite. ...Read more

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Can you have a healthy baby if you have meyloproliferitive disorder?

Can you have a healthy baby if you have meyloproliferitive disorder?

Of course!: Matermal medical conditions can generally be managed throughout pregnancy to avoid or minimize fetal consequenses (mainly from prematurity, poor growth and teratogen exposure). Myeloproliferative disorders (blood dyscrasias) are no exception; they can present challenges to the maternal-fetal medicine and hematology specialists managing the pregnancy, but these should be surmountable. ...Read more

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Is it common to have clonal proliferation in myeloprliferative disorders?

Is it common to have clonal proliferation in myeloprliferative disorders?

Yes it is: Your hematologist can explain it well. Just ask him/her. You should know which type of myeloproliferative disorder do you have. It can be cml, myeloid metaplasia or polycythemia vera ...Read more

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What causes myloproliferative disorder?

What causes myloproliferative disorder?

In most csses: There is no identifiable cause. It is acquired not genetic (inherited). ...Read more

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Can gestational diabetes be dangerous if you have meyloproliferitive disorder?

Can gestational diabetes be dangerous if you have meyloproliferitive disorder?

No more than usually: Chronic medical maternal conditions can predispose to gestational diabetes mellitus or gdm (either inherently or due to their medical management), but should not alter the significance of gdm once diagnosed. A myeloproliferative disorder could presidpose you to pregnancy complications as well. I can only think of infectious scenarios in which the two diagnoses would potentiate each other's effects. ...Read more

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Father diagnosed with essential thrombocytosis. Doc thinks I may have polycythemia vera. Are these genetic since both are myloprolofitive disorders?

Both are: Myelproliferative disorders so you would label it one or the other. Pcrv can have a high platelet count. You would say et if it seems to be a platelet only phenomenon. Disorders are related and acquired, rather than genetic in the inherited sense. ...Read more

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My father has high cholesterol and essential thrombocytosis (myloprolifitive disorder) his hs, CRP elevated at 4.5. Pravastatin & aspirin good treatm?

My father has high cholesterol and essential thrombocytosis (myloprolifitive disorder) his hs, CRP elevated at 4.5. Pravastatin & aspirin good treatm?

These sound: Like usual treatment for the conditions you describe. But a lot depends on his actual platelet count and cholesterol profile. Sounds like he has a doctor already, so I would follow the doctor's advice. ...Read more

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What are mylo proliferative neoplasms?

Blood disorder: It is a big group of blood neoplasm - where can be classified further into many different conditions - among of them will include - chronic myelogenous leukemia, polycythemia vera. Essential thrombocythemia, myelofibrosis, chronic eosinophilic leukemia, systemic mastocytosis etc- depending on which clones that are affected. Those conditions can transform into acute leukemia. ...Read more

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Does the myloprolifitive blood cancer- polycythemia vera cause weight loss and fatigue?

Yes, it can cause.: In addition to the prolems of thromosis from excess cellular volume, patients have general symp. Such as fatigue-in nearly 80 percent of people, generalized itching, night sweats, fever, bonepain, and weight loss. Any type of cancer whether blood related or not-like lung, breast cancer patients have symptoms have weight loss, fatigue as cels proliferate in great numers in a short period. ...Read more

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Pls help im confused! My wife did high vaginal swab c/s is it because she take pipolar disorder medicine?

Pls help im confused! My wife did high vaginal swab c/s is it because she take pipolar disorder medicine?

STI: I don't see why there could be a connection between medications for bipolar disorder and vaginal infections. Most of the time vaginal swabs are done to detect gonorrhea, chlamydia, trichomonas, and bacterial vaginosis, which are sexually transmitted infections, or candida vaginitis. ...Read more

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What medicines are use for lou gehrig's disease?

What medicines are use for lou gehrig's disease?

Treatment: It's mostly supportive, but a drug called Riluzole is approved for ALS and it's thought to work by decreasing glutamate mediated motor neuron cell death. ...Read more