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Doctor insights on: Medicine For Myelofibrosis

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What is myelofibrosis?

What is myelofibrosis?

Myelofibrosis: A blood disorder which usually affects the bone marrow causing anemia and low counts, and cause spleen enlargement and other constitutional symptoms like weight loss, malaise, risk of infection and bleeding. It can lead to leukemia or a bone marrow failure syndrome. Bone marrow transplant in young patients can be considered. Jakafi (ruxolitinib) is a new drug approved to treat symptoms of myelofibrosis. ...Read more

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Why myelofibrosis occur?

Why myelofibrosis occur?

Stem cell damage.: Myelofibrosis is associated with damage to dna of bone marrow stem cells. This results in abnormal growth and functioning of these cells. The most common gene mutation is in jak2 where a tiny change in the gene drives the abnormal growth, but there other mutations that occur. Mf is one of the myeloproliferative neoplasias, all caused by similar gene damage. ...Read more

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Can myelofibrosis be fixed?

Can myelofibrosis be fixed?

Myelofibrosis: Difficult disease to fix, if can be managed. Young patients bone marrow or stem cell transplant is an option. ...Read more

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Is myelofibrosis. Hereditary?

Is myelofibrosis. Hereditary?

Almost never: Common myelofibrosis and its cousin myeloid metaplasia are almost always sporadic. There are a few genetic marrow-failure syndromes but these are fairly easy to recognize. ...Read more

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Is danogal for myelofibrosis?

Is danogal for myelofibrosis?

Danazol perhaps?: Myelofibrosis (mf) is a blood condition where the bone marrow is replaced by scar tissue (fibrosis). One problem that develops is anemia. Medications related to testosterone (androgens) sometimes help. Danazol is one such drug. It has many other uses. Other drugs for mf include jak2 inhibitors, thalidomide derivatives, epoietin and hydroxyurea. ...Read more

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What is prognosis for myelofibrosis?

What is prognosis for myelofibrosis?

Depends: They are several phases of the disease and it depends on how much fibrosis is present in the marrow. Since this is included in the group of disorders known as myeloproliferative neoplasms, it can develop into a leukemia. Hope this was helpful. ...Read more

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Tell me about chronic idiopathic myelofibrosis?

Tell me about chronic idiopathic myelofibrosis?

Pmf: A condition where there is a significant and uncontrolled growth/increase of reticulin fibre inside thebone marrow resulting in decrease production of normal blood cells inside the. One matrow, increase production of hematopoietic cells outside the bone marrow, and if severe enough also associated with weight loss, bony pain, increase spleen size, malaise etc. Bone marrow transplant is to cure ...Read more

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Does myelofibrosis always have noticeable symptoms?

Does myelofibrosis always have noticeable symptoms?

Not initially: Myelofibrosis is a disease of the bone marrow which causes increasing fibrosis (scarring) over time and loss of the marrow to function normally. Thus until the marrow is harmed to the degree where you develop anemia or low platelets or low white blood cells you will normally not experience any symptoms. ...Read more

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Is there a complete cure for myelofibrosis?

Is there a complete cure for myelofibrosis?

Transplant: The only potential cure for myelofibrosis is an allogeneic stem cell transplant. This requires a stem cell donor and cannot be done with the patient's own stem cells. ...Read more

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Is idiopathic myelofibrosis a form of leukemia?

Is idiopathic myelofibrosis a form of leukemia?

No: Primary idiopathic myelofibrosis is under umbreall of myeloproliferative neiplasm-where for some unknown reasons, there is uncontrolled increased production of reticulin fibres inside the bone marrow space. While it is not a form of leukemia, however it can transform into acute leukemia. ...Read more

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How do you treat myelofibrosis on the 69-year-old male?

How do you treat myelofibrosis on the 69-year-old male?

Multiple options: Depending on symptoms, options include transfusions, drugs to stimulate red cell production (erythropoietin, androgens), thalidomide derivatives (lenolidomide, pomalidomide), jak2 inhibitors (jakafi), splenectomy, radiation therapy, chemotherapy (hydroxyurea) or bone marrow transplant. ...Read more

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I've been told my life expectancy is around 5 years. What course will myelofibrosis take to ultimately lead to my death? Why my prognosis now terminal

Myelofibrosis: I am so very sorry to hear of this diagnosis.
I have cared for people over several decades as their doctor with this horrible disease. It has no known cause and no effective treatment. It is a scarring of the bone marrow leading to inability to produce life saving red blood cells, white blood cells and platelets. See if a large center (if near one) that specializes in clinical trials can help ...Read more

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What cancer would cause myelofibrosis in a 57 year old woman?

What cancer would cause myelofibrosis in a 57 year old woman?

It is a disease: Myelofibrosis is a type of cancer itself although initially it may not show Cancer cells initially. Most such patients develop Leukemia after a period of one to two years. Go see a hematologist if you need further help ...Read more

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Do you know which cancer would cause myelofibrosis in a 57 year old woman?

Do you know which cancer would cause myelofibrosis in a 57 year old woman?

Unknown: The known forms of bone marrow cancer do not cause myelofibrosis Rather Myelofibrosis is a rare form of cancer of the bone marrow itself where the marrow is replaced by scar tissue and is not able to make healthy blood cells. It is considered to be a form of chronic leukemia and represent a group of blood disorders called myeloproliferative disorders. ...Read more

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I have myelofibrosis and complication of hardening of connective tissues. Is there a treatment for this complication?

I have myelofibrosis and complication of hardening of connective tissues. Is there a treatment for this complication?

Maybe.: Myelofibrosis is a unusual disease of blood and bone marrow where the marrow is replaced by what looks like scar tissue. This results in bone marrow cells moving to the liver and spleen, those organs enlarge and become hard. There is one drug, jakafi, (ruxolitinib) fda approved to shrink the spleen. There are other drugs like it in trial. Only cure is bone marrow transplant, but there are significant risks. ...Read more

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I've been diagnosed with myelofibrosis after many years looking for a cause to my poor health. Will I ever be cured? Is it a cancer, I've read both.

I've been diagnosed with myelofibrosis after many years looking for a cause to my poor health. Will I ever be cured? Is it a cancer, I've read both.

Not cancer: It is a mutation in a protein jak2 that causes scar tissue in the bonemarrow where you don't make enough red cells. There are more treatments coming but now most treatment is aimed at your symptoms. At this point there is no cure. ...Read more

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My haemotologist told me I have around 5 years before I die from myelofibrosis. What can I expect? Am already in wheelchair as I fafaint when walking.

My haemotologist told me I have around 5 years before I die from myelofibrosis. What can I expect? Am already in wheelchair as I fafaint when walking.

None of us truly: Knows when we will die but you have some information from your doc. Many will die before you so please make the very best to the time you have. Try to use your suffering to help others somehow, perhaps on line. Peace and good health. ...Read more

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Are myelofibrosis and multiple myeloma are related to each other?

Are myelofibrosis and multiple myeloma are related to each other?

No: They are totally different diseases. Myeloma is a malignancy that develops in a type of blood cell called a plasma cell. Myelofibrosis is a disease of the bone marrow microenvironment. ...Read more

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My sister is diagnostic to myelofibrosis. Which treatments would be more curable?

Primary myelofibrosi: Allogeneic bone marrow transplantation would be the only curative option for myelofibrosis. Other treatment like jak 2 inhibitor, immunomodulator agent, steroids, etc are only for symptom relief/ palliative therapy. ...Read more

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Could heart palpitations be a symptom of myelofibrosis?

Could heart palpitations be a symptom of myelofibrosis?

Possibly: This would not be an early sign of this problem. As you know, this condition can cause an anemia and this could cause your heart to beat faster, but your would have to be very anemic to experience palpitations. If you are concerned get it check out by your doctor. ...Read more

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I'm 40 diagnose with stage 3 myelofibrosis, swollen gland, enlarged spleen, current dr won't treat any symtoms. How many stages are there?

I'm 40 diagnose with stage 3 myelofibrosis, swollen gland, enlarged spleen, current dr won't treat any symtoms. How many stages are there?

Seek a 2nd opinion: If you are not happy with your present oncologist, it is time to seek a second opinion from another hematologist/oncologist. There is good treatment available for Myelofibrosis....stage of disease in not all that relelvent once the patient has enlarged Nodes/spleen and has symptoms requiring relief. ...Read more

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I have myelofibrosis and my left arm falls asleep when I sleep and takes several hours to "wake up" feels lead, upper outer portion of arm?

I have myelofibrosis and my left arm falls asleep when I sleep and takes several hours to "wake up" feels lead, upper outer portion of arm?

"pinched" nerve.: Sounds like a peripheral neuropathy not likely related to the myelofibrosis. Should look for a "pinched" nerve somewhere between your neck and your wrist. This frequently happens during sleep. I'll bet sleeping in a chair cures your symptom. ...Read more

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84 yr old w dc of myelofibrosis has a serum calcium dropping. Why is this happening and what ser calcium level becomes concerning? Does taking calcium supp help?

84 yr old w dc of myelofibrosis has a serum calcium dropping. Why is this happening and what ser calcium level becomes concerning? Does taking calcium supp help?

Unclear why Ca drop: It is not clear why the ca is dropping. This is not generally a result of myelofibrosis. The ca is generally low if the Albumin level is low. Is that the problem? If so, the ca is actually falsely low. Perhaps there are nutritional problems, medications, or other underlying health problems leading to the low ca. This problem should be evaluated by a health care provider. ...Read more

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Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Progressive: Yes, you described it well. New treatments are becoming available all the time, and they could extend your life! Get treated! ...Read more

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I have myelofibrosis. How does the disease progress? Does your marrow just keep becoming scar tissue that can't produce blood? Is bone pain common?

I have myelofibrosis. How does the disease progress? Does your marrow just keep becoming scar tissue that can't produce blood? Is bone pain common?

Yes : (: The disorder is characterized by anemia, fatigue, bone or joint pain, and an enlarged liver and spleen.

http://blog. Mountsinai. Org/blog/physicians-identify-successful-drug-for-myelofibrosis/. ...Read more

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What does having bone marrow cells move to and enlarge the liver and spleen indicate in myelofibrosis? Does this change the prognosis?

Advanced stage: When bone marrow cells move to spleen/liver, it may mean bone marrow is failing & cannot make blood cells effectively. Therefore, the spleen & liver take over to do the job- then they get enlarged & blood count also drops & many patients may require transfusions. Patients may have fevers etc. Treatment is available for enlarged spleen & fevers. (jakafi).Younger patients may need transplant. ...Read more