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Doctor insights on: Medicine For Mastocytosis

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Agg. Systemic mastocytosis. This mean my anaphylaxis food/drug allergies will now end since on Cromolyn? Could ITP dx be part of ASM or can have both?

Agg. Systemic mastocytosis. This mean my anaphylaxis food/drug allergies will now end since on Cromolyn? Could ITP dx be part of ASM or can have both?

No, and No: Cromolyn will not end probability of anaphylaxis, and if it happens needs to be treated, ITP isn't part of the disease, yes a patient can have both as separate diseases, aggressive severe mastocytosis is a rare disease, much rare than systemic mastocytosis, which is already a rare disease, diagnosis / management need to be in a tertiary care facility, need to adhere to treatment well & follow up ...Read more

Dr. Brant Ward
44 Doctors shared insights

Mastocytosis (Definition)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more


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What is mastocytosis?

What is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Does mastocytosis go away?

Does mastocytosis go away?

Usually: Most cases of cutaneous (just in the skin) mastocytosis start in childhood and will go away as a person gets older. Sometimes the spots may stay but the reactions from them (itching or hives when the spots are irritated) fade over time. Systemic mastocytosis (throughout the body and bone marrow) is much rarer, but usually will not go away. See as specialist in mastocytosis for more information. ...Read more

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Does mastocytosis go away?

Does mastocytosis go away?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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How to control mastocytosis?

How to control mastocytosis?

Certain meds: Cutaneous masto can be treated with daily oral antihistamines or cromolyn applied to the skin, but sometimes may not need treatment. Systemic masto is usually treated with antihistamines, plus oral cromolyn for GI symptoms and epipen (epinephrine) for anaphylactic episodes. Aggressive forms may only respond to certain chemotherapy agents. See a specialist in masto for more information. ...Read more

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What does mastocytosis mean?

What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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What exactly is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Anyone diagnosed mastocytosis? How?

Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

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Anyone have mastocytosis? What is it?

Anyone have mastocytosis? What is it?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone here have treated mastocytosis?

Anyone here have treated mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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What are the symptoms of mastocytosis?

What are the symptoms of mastocytosis?

It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more

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What is mastocytosis and is it serious?

Mastocytosis: Is an excess number of mast cells. It is usually not an aggressive process. ...Read more

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What can you do to control mastocytosis?

Medications can help: Cutaneous (skin-only) mastocytosis can be treated with antihistamines, singulair, (montelukast) and topical cromolyn if the itching, etc., is problematic. The same meds can help systemic mastocytosis, with swallowed cromolyn for GI symptoms. Epinephrine can help resolve anaphylaxis if that occurs. Avoid codeine/opiates and other meds that directly activate mast cells. Talk with a specialist for more info. ...Read more

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How do I find information on mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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What is the definition or description of: mastocytosis?

What is the definition or description of: mastocytosis?

Too many mast cells: Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine from the mast cells. ...Read more

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I have mastocytosis and I want it to go away. What to do?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone out here dealing with mastocytosis and found a cure?

Anyone out here dealing with mastocytosis and found a cure?

See below: Patients with cutaneous and indolent systemic mastocytosis have a favorable prognosis, over 95% of them life expectancy is not reduced. In >50% of the cases of cutaneous mastocytosis in children, there is remission by the time the patient reaches adolescence. In adults it is generally chronic; only in a small proportion of patients with indolent systemic mastocytosis does it tend to regress. ...Read more

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I have mastocytosis and I want it to go away. What can you do?

I have mastocytosis and I want it to go away. What can you do?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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How do I find information on mastocytosis on a reputible site?

How do I find information on mastocytosis on a reputible site?

NIH website: The national institutes of health have good information about mastocytosis on their website: http://www. Niaid. Nih. Gov/topics/mastocytosis/pages/default. Aspx
the mastocytosis society is a patient-run organization, and they have some good information on their website as well: http://www. Tmsforacure. Org/welcome. Php

if you have specific? S, you should see a specialist with experience in mastocytosis. ...Read more

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Anyone know if there is a website with helpful information on mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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How to treat mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Is there a cure for mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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What is a cure for mastocytosis?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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Anyone have a baby with mastocytosis?

Anyone have a baby with mastocytosis?

Yes: There are no accurate data on the frequency of mastocytosis. Annual incidence of 5-10 new cases per million population is estimated. In dermatological practices and hospital departments of dermatology, 1 of every 1000 to 8000 new patients has mastocytosis. The most frequently encountered forms are cutaneous mastocytosis and indolent systemic mastocytosis. The least common is mast cell leukemia. ...Read more

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What is done for systemic mastocytosis?

What is done for systemic mastocytosis?

Control of symptoms: After diagnosis, treatment is mostly focused on controlling symptoms. Flushing, itching, and (to some extent) GI symptoms are helped by antihistamines +/- leukotriene antagonsists (e.g. Monteleukast). More severe GI symptoms are treated with cromolyn. Cromolyn mixed with lotion can sometimes help severe itching. Epipen (epinephrine) is used for anaphylactic episodes. See a specialist in masto for more info. ...Read more

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What are the signs of mastocytosis or mcas?

What are the signs of mastocytosis or mcas?

Hives, anaphlaxis: Cutaneous mastocytosis typically presents as small brown splotches that turn in hives or welts when irritated, but it can affect the entire skin surface, too. Systemic masto and MCAS typically presents with spontaneous episodes like anaphylaxis--dizziness, fainting, flushing, nausea, diarrhea, and sometimes hives and trouble breathing. See a specialist in masto for more info. ...Read more

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What do you know about systemic mastocytosis.?

What do you know about systemic mastocytosis.?

See below: Systemic mastocytosis, often termed systemic mast cell disease (smcd), is a heterogeneous clonal disorder of the mast cell and its precursor cells. It is now classified as a myeloproliferative neoplasm. It is characterized by mast cell infiltration of extracutaneous (not skin) organs. ...Read more

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Help! I have aggressive systemic mastocytosis. What do I do?

See a specialist!: Treatment of aggressive systemic mastocytosis can be extremely complex. If at all possible, you should see a specialist with experience treating this disorder. The mastocytosis society maintains a list of specialists, which can be viewed at http://tmsforacure. Org/patients/research_centers_1.Php. There are ongoing clinical trials for treatments that may help slow the progression of the disease. ...Read more

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I have a 5 month old with mastocytosis. What advice for care?

I have a 5 month old with mastocytosis. What advice for care?

Not Much: Usually the only major symptom is itching. This is treated at this age locally with antihistamine or steroid cream. Otherwise is a benign condition most of the time. ...Read more

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Please please tell me everything about systemic mastocytosis.?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more