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Doctor insights on: Medicine For Iga Deficiency

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What are the tests for IgA deficiency?

What are the tests for IgA deficiency?

Blood test: To determine if you have an IgA deficiency, a simple blood test can be done. ...Read more

Dr. Zamaneh Mikhak
70 Doctors shared insights

Iga Deficiency (Definition)

Inability to make a class of antibody (IgA) that plays a major role in mucosal immunity (gut and respiratory tract predominantly). May result in recurrent infection, but is often discovered incidentally. May also forecast the development of a more severe immune problem called combined variable immune deficiency (CVID) or be a risk factor for an anaphylactic reaction to ...Read more


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Anybody know much about this IgA deficiency?

Anybody know much about this IgA deficiency?

Maybe no issue: Ig a is one of the 5 known immunoglobulins in human. Isolated IgA deficiency occurs in 1/500 of the population and is not usually associated with susceptibility to infections unless there is an igg deficiency as well. If you are healthy otherwise, don't worry about it. On the other hand, was the blood test obtained because she gets frequent sinus or lung infections in the first place? ...Read more

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What is IgA deficiency and does it need to be treated?

What is IgA deficiency and does it need to be treated?

Maybe no issue: Ig a is one of the 5 known immunoglobulins in human. Isolated IgA deficiency occurs in 1/500 of the population and is not usually associated with susceptibility to infections unless there is an igg deficiency as well. If you are healthy otherwise, don't worry about it. On the other hand, was the blood test obtained because she gets frequent sinus or lung infections in the first place? ...Read more

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How common is a partial IgA deficiency? Mine is 37 mg/dl

How common is a partial IgA deficiency? Mine is 37 mg/dl

Selective IgA defic.: Prevalence varies by population, but is on the order of up to 1 in 333 people making it relatively common for a genetic disease. It is more common in males than in females. IgA is primarily in secretions of the mucosal surfaces, including tears, saliva, colostrum, genital, respiratory and gastrointestinal secretions, and if symptoms develop they are usually related to infections in these areas. ...Read more

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What is the definition or description of: IgA deficiency?

IgA deficiency: Inability to make a class of antibody (IgA) that plays a major role in mucosal immunity (gut and respiratory tract predominantly). May result in recurrent infection, but is often discovered incidentally. May also forecast the development of a more severe immune problem called combined variable immune deficiency (CVID) or be a risk factor for an anaphylactic reaction to blood products with IgA. ...Read more

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Iga is 38mg/dl. My dr said it's not considered IgA deficiency and some people just fall below the average. True?

May be it is normal: Normal Values fall between 100 - 600 mg/dl. Many are below 100, but not considered deficiency in Iga, and are asymptomatic.But may need more screening like DOUBLE IMMUNODIFFUSION ASSAY TEST normal value is 2 - 4 mg/dl. If ...Read more

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Iga was measured to be low at 40 mg/dl. Range was above 68mg/dl. Dr said it isn't IgA deficiency because it's too high. What caused this then?

Iga was measured to be low at 40 mg/dl. Range was above 68mg/dl. Dr said it isn't IgA deficiency because it's too high. What caused this then?

No IgA deficiency: Your IgA is a little lower than the average. It is not low enough to be called deficiency. Iga deficiency used to be IgA of less than 30mg/dl, occurring in 1 in 500 people. A level of less than 1mg/dl occurs in 1 in 2000 people. The primary cause is unknown, but there is failure of certain b lymphocytes to mature into IgA producing plasma cells. If you have no symptoms - no treatment necessary. ...Read more

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My daughter found out she has IgA deficiency/what is that?

My daughter found out she has IgA deficiency/what is that?

Immune problem: Iga is an antibody produced by our immune system. It can be found in the blood but is mainly secreted into mucous membranes -- sinuses for example. It is the most common immunodeficiency. Go to www. Primaryimmune. Org for some really good info on IgA deficiency. ...Read more

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Hi doctors, can you tell me what is IgA deficiency and how can it be helped?

IgA deficiency: Or rather selective IgA deficiency, still a rare disease, but the most common type of immunodeficiency, at times associated with IgG subclass deficiency, usually asymptomatic, but can have upper respiratory problems, can be prone to auto-immune diseases, need to be cautious with blood or blood products infusion, if diagnosed or suspected please get evaluated by an allergist/immunologist, take care ...Read more

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How often does partial IgA deficiency turn into cvid? Pigad diagnosed at 26.

Selective IgA defic.: Most persons with this remain without significant illness. It is not known exactly how many individuals with IgA deficiency will eventually develop complications; estimates range from 25% to 50%, but these people often have severe deficiencies, often accompanied by defects in other immunoglobulins or other elements of the immune system. ...Read more

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How often does IgA deficiency progress to cvid? I was tested at 26 and don't have cvid. Is it likely to turn into cvid?

Depends on level: If there is true deficiency, 20 % get symptoms before 16 years of age. Most people developed in their 3rd or 4th decade of life. Male and female equally. Recurrent infections of nose, ear, sinus, lung, abdomen, enlarged lymph nodes in neck and abdomen etc.
But first of all one should determine if deficiency exit or not by using more sophisticated tests. ...Read more

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Is an IgA level of 38 mg/dl considered IgA deficiency? I keep reading it has to be under 5 mg/dl to be called an IgA deficiency. Why would mine be low?

Low, not low enough: When normal IgA levels are determined, they are usually based on the average values of the population tested and the age of the patient. There are usually 2-5 % of normals that are included in the low range. You can relax. Even though 38 may be low, it is high enough to protect you against infections. If you have levels less than 20 mg/dl then you would be at risk for recurrent infection. ...Read more

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Gf diagnosed with IgA deficiency, now diagnosed with scid. Related?

Gf diagnosed with IgA deficiency, now diagnosed with scid. Related?

SCID: Scid stands for severe combined immunodeficiency. By definition, people with this disorder have no t cells, so they cannot fight any diseases or produce any antibodies. Iga is one type of antibody, so a deficiency of it would be expected as part of the scid disorder. This disorder is fatal in infancy without aggressive management, so not likely to be diagnosed in an adult. Cvid more likely. ...Read more

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Could an IgA deficiency prevent my body from making antibodies?

Could an IgA deficiency prevent my body from making antibodies?

IgA deficiency: Iga is an antibody, so a deficiency of IgA means your body is having trouble making that type of antibody. Iga deficiency does not cause you to be unable to make other antibodies. It just means you aren't able to make the IgA class of antibodies, so antibodies of that type will probably not be detected if they are sought, for example, in a blood test for celiac or other diseases. ...Read more

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I have IGA deficiency and get sick a lot. When sound I get my kids tested for it and yes they all have HLA-B27.?

I have IGA deficiency and get sick a lot. When sound I get my kids tested for it and yes they all have HLA-B27.?

Hereditary: If there are symptoms or signs of an autoimmune disease, a positive HLA-B27 test may confirm the diagnosis. However, HLA-B27 is normally found in a small number of Caucasians and does not always mean you have a disease. Hope the kids stay free of illness. ...Read more

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What type of doctor should I see for selective IgA deficiency?

What type of doctor should I see for selective IgA deficiency?

Immunologist: Although there is no real treatment for it, you can consult an allergist/immunologist about it. ...Read more

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What is it? 3year old with IgA deficiency. Has fever of 102-103 for 3-4 days after physical activity. Happens frequently.

Hard to predict: IgA deficiency patients are prone to an increased number of infections of the sinuses, lungs and intestines. They can also develop rheumatoid diseases, lupus, hepatitis and other issues. Only a full history, exam and appropriate testing can sort out these patients. ...Read more

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My 2 1/2 yr old daughter has vcfs (22q11.2 deletion syndrome) with this she has an IgA deficiency & recurrent bronchitis. I need a helpful website.

22q and you site: Hi lily,
the children's hospital of philadelphia (chop) has a great site for parents and health care providers called "22q and you center". http://www. Chop. Edu/service/22q-and-you-center/home. Html. They take online questions, and have links to support groups for kids, teens, and families. I'd also recommend family voices (familyvoices. Org) --a great site with info on advocating for your child. ...Read more

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I have negative celiac blood test and no IgA deficiency but biopsy shows chronic non-specific duodenitis and celiac symptoms are present. Need help.?

I have negative celiac blood test and no IgA deficiency but biopsy shows chronic non-specific duodenitis and celiac symptoms are present. Need help.?

Be more specific: If IgA tTG was negative, there is a very little chance that you have celiac disease. However, other conditions may mimic gluten-sensitivity and some people may actually be allergic to wheat itself causing similar symptoms. The biopsy findings should be quite specific for gluten intolerance. What actually are your symptoms? ...Read more

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Is it common to have celiac disease if you have SLE? I have selective IgA deficiency

Yes there is: Celeac desease, IGA deffifficiency are all immune mediated disorders
it is advisable that you have an immunologist involved in your care
stay well! ...Read more

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Iga deficiency danger of anaphylaxis to blood transfusions they tell me; is that true?

Iga deficiency danger of anaphylaxis to blood transfusions they tell me; is that true?

Yes: It is true. The idea is that since a person with IgA deficiency has never seen the IgA that comes in blood transfusions, their body will treat it like a foreign protein and can have an allergic or even anaphylactic response. ...Read more

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Overheard medical student talking with pediatrician in the hall. What is IgA deficiency?

Overheard medical student talking with pediatrician in the hall. What is IgA deficiency?

Immunodeficiency: Iga immunodeficiency is the most common form of immunodeficiency. Iga is a blood product that is found in the mucous that lines our noses, sinuses and other areas of our body. It can be considered a first line of defense. Generally these patients do very well but can have recurrent sinus infections and can dev other immunodef. Iga def pt are a risk for bad rxn to blood products. ...Read more

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My 2 1/2 yr old daughter has a genetic disorder called vcfs (22q11.2 deletion syndrome) with this she has an IgA deficiency which has manifested as recurrent bronchitis. What's a good website for info?

My 2 1/2 yr old daughter has a genetic disorder called vcfs (22q11.2 deletion syndrome) with this she has an IgA deficiency which has manifested as recurrent bronchitis. What's a good website for info?

The VCFS Educational: Foundation has webinars. Their conference for parents and professionals is in my home town this year. I couldn't resist adding the iconic photo. If your child has adhd, as is very common in people with vcfs, just know that circus circus can be an overstimulating environment for any child....Or adult. ...Read more

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I have a large spleen, too many lymph-nodes in the abdomen, an IgA deficiency, bruise without hitting anything, weakness, body aches&pains, what is this?

I have a large spleen, too many lymph-nodes in the abdomen, an IgA deficiency, bruise without hitting anything, weakness, body aches&pains, what is this?

IGA deficiency: IGA deficiency means you need an immunologist, at least. Large spleen and nodes can be a symptom of IGA issues. However spleens can get large enough to cause platelet problems and bruising. Additional exam and testing are needed. ...Read more