Top
20
Doctor insights on: Medicine For Hereditary Colon Cancer

Share
1

1
Can you explain hereditary colon cancer?

Can you explain hereditary colon cancer?

Not in 400 character: Many genes are linked with an increased risk of colon cancer (and others), so those with a family history of colon, uterine and other cancers are at increased risk as they may inherit these genes from their parents. Genetic testing can pinpoint some of these genes and thus indicate whether you are at increased risk, thus allowing earlier detection/prevention/treatment so get checked if this appies. ...Read more

See 1 more doctor answer
Dr. Barry Rosen
4,342 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


2

2
What are the symptoms of hereditary colon cancer?

What are the symptoms of hereditary colon cancer?

None: Colon cancer does not cause symptoms unless advanced. Definitely bleeding rectally is one that you should not ignore. ...Read more

See 1 more doctor answer
3

3
What is the definition or description of: Hereditary colon cancer?

What is the definition or description of: Hereditary colon cancer?

5-10% of colon CA's: ...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). Read: https://www. Mskcc. Org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/inherited-risk-colorectal ...Read more

4

4
What is the treatment for hereditary colon cancer?

What is the treatment for hereditary colon cancer?

Depends: There are a number of inherited defects that may lead to colon cancer. In some cases, e.g. Apc, a prophylactic colectomy is advisable. In most cases the treatment is the same as for sporadic cancer. ...Read more

See 1 more doctor answer
5

5
Question about hereditary colon cancer. Can it skip generations?

Question about hereditary colon cancer. Can it skip generations?

Yes: The genes that contribute to colon cancer are related to how cells grow or repair themselves. Skipping a generation may mean that the gene is not fully expressed or that other environmental factors did not quite tip the balance in favor of cancer. ...Read more

6

6
Question about hereditary colon cancer: which kinds are inherited or run in families?

Question about hereditary colon cancer: which kinds are inherited or run in families?

Several.: The types of colorectal cancers you refer to include hnpcc (hereditary nonpolyposis colorectal cancer) and fap (familial adenomatous polyposis). However, each of these can also arise form a new mutation with no family history. Garden variety colorectal cancer also has some heritability, though far less than those noted above. ...Read more

See 1 more doctor answer
7

7
If a person in their mid 30's were to get colon cancer would it almost always be due to a hereditary form of cancer compared to sporadic?

If a person in their mid 30's were to get colon cancer would it almost always be due to a hereditary form of cancer compared to sporadic?

Maybe: Some hereditary factors increase colon cancer risks such as some types of colitis (ulcerative colitis, crohn's disease), familial polyposis, hnpcc, lynch syndrome, etc. But younger people can get spontaneous colon cancers too. Get a referral to a gastroenterologist as indicated. Most colon cancer occurs after age 50, and reported 8-10 people per 100, 000 get colon cancer under age 50. ...Read more

See 1 more doctor answer
8

8
Is neo 102 drug effective for colon cancer mets.? Is it different to chemotherpay?

Is neo 102 drug effective for colon cancer mets.? Is it different to chemotherpay?

Investigational: NEO 102 is a monoclonal antibody, not what is usually meant by the word chemotherapy. It is the subject of ongoing clinical trials. Therefore it is not yet known whether the drug is useful, harmful, or indifferent. In the U.S. it would only be available for subjects in a clinical trial. I suspect, but am not certain, that that is true in the U.K. Too. ...Read more

9

9
How is colon cancer inherited?

How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

See 2 more doctor answers
10

10
Help please! Is colon cancer hereditary?

Help please! Is colon cancer hereditary?

Can be: Most colon cancers relate more to lifestyle than inheritance but some patients do have an inherited predisposition, be it in the setting of multiple polyps (like fap or myh) or not (lynch syndrome). Families with this have early onset colon cancer and other cancers as well. Talk to your doc about this to see if you need to visit a specialist in inherited malignancies. Remember to live healthy. ...Read more

11

11
I need your expertise, is colon cancer hereditary?

I need your expertise, is colon cancer hereditary?

Some colon cancers: Are hereditary. Vast majority are not. The two common hereditary forms of colon cancer are familial adneomatous polys and lynch syndrome. Let me reiterate that hereditary colon cancers are a minority. See this site for more info.
http://www. Mskcc. Org/cancer-care/hereditary-genetics/inherited-risk-colorectal. ...Read more

12

12
Is colon cancer Hereditary? Note my father and aunt has it. How can I identify iam 26 now

Is colon cancer Hereditary? Note my father and aunt has it. How can I identify iam 26 now

Family risk: You will want to get colonoscopy from time to time starting soon. Your family members may also be checked for genetic problems such as HPNCC and familial polyposis; if they are affected, you may be checked as well. Getting 'scoped frequently greatly diminishes your risk of dying of this illness. ...Read more

13

13
I mean if chemotherapy does not work fir metastic colon cancer, can anything be done, any new drugs?

I mean if chemotherapy does not work fir metastic colon cancer, can anything be done, any new drugs?

Yes: Depending where mets are, direct therapy can be offered resecting lung lesions locally, using chemoembolization for lesions in liver and hyperthermic perfusion for peritoneal seeding. Immunotherapy for VEGF and epidermal growth factors can also be employed as well as new drugs in Phase II-III such as mAbs targeting post translational modification of MUC5ac and CEAcam 5, 6`oncofetal proteins/ ...Read more

See 1 more doctor answer
14

14
If there's hereditary predisposition of colon cancer how often should a person do colonoscopy and wha are the risk factors? And What is polyposis test?

If there's hereditary predisposition of colon cancer how often should a person do colonoscopy and wha are the risk factors? And What is polyposis test?

Colon CA/screening: ACS screening for families that have a strong history. There are families that have predisposition to develop color and rectal CA. They say screening should start 10 yrs prior to the family members Dx. Say mom Dx at 40, screening would start at 30 in her family. Once you've had the first scope re can be made on the frequency, every 3 to 5 yrs depending on number of members Dx. ...Read more

15

15
Are there any new cancer drugs for colon cancer spread to the liver? My father is very ill and needs help.

Are there any new cancer drugs for colon cancer spread to the liver? My father is very ill and needs help.

Consider new trials: If I were in your father's position, I would consider being in a research trial (if one is available) for metastatic colon cancer. None of the approved therapies for this is curative; they are all palliative. I would probably favor something with an immune-based approach rather than a cell poison, if any such trial is available. This is just a personal preference I'm voicing. ...Read more

See 1 more doctor answer
16

16
Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed?

Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed?

Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more

17

17
Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets? Is it a risky drug

Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets? Is it a risky drug

Slight benefit: Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30, 000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems. ...Read more

18

18
Can children get colon cancer?

Can children get colon cancer?

Yes: Usually adult children. The youngest patient I have seen in my practice with a family history of colon cancer, was first diagnosed at age 18. ...Read more

See 1 more doctor answer
20

20
Where does colon cancer spread to?

Colon ca mets: Most commonly to the liver. Then to the lungs. Rectal cancer may spread to lung before spreading to liver. ...Read more

See 1 more doctor answer
Dr. Jan Rakinic
89 Doctors shared insights

Hereditary Colon Cancer (Definition)

...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). ...Read more


Dr. Gregory Moneta
13 Doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more