Doctor insights on:
Medicine For Hereditary Colon Cancer
Not in 400 character: Many genes are linked with an increased risk of colon cancer (and others), so those with a family history of colon, uterine and other cancers are at increased risk as they may inherit these genes from their parents. Genetic testing can pinpoint some of these genes and thus indicate whether you are at increased risk, thus allowing earlier detection/prevention/treatment so get checked if this appies. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
5-10% of colon CA's: ...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). Read: https://www. Mskcc. Org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/inherited-risk-colorectal ...Read more
Several.: The types of colorectal cancers you refer to include hnpcc (hereditary nonpolyposis colorectal cancer) and fap (familial adenomatous polyposis). However, each of these can also arise form a new mutation with no family history. Garden variety colorectal cancer also has some heritability, though far less than those noted above. ...Read more
If a person in their mid 30's were to get colon cancer would it almost always be due to a hereditary form of cancer compared to sporadic?
Maybe: Some hereditary factors increase colon cancer risks such as some types of colitis (ulcerative colitis, crohn's disease), familial polyposis, hnpcc, lynch syndrome, etc. But younger people can get spontaneous colon cancers too. Get a referral to a gastroenterologist as indicated. Most colon cancer occurs after age 50, and reported 8-10 people per 100, 000 get colon cancer under age 50. ...Read more
Investigational: NEO 102 is a monoclonal antibody, not what is usually meant by the word chemotherapy. It is the subject of ongoing clinical trials. Therefore it is not yet known whether the drug is useful, harmful, or indifferent. In the U.S. it would only be available for subjects in a clinical trial. I suspect, but am not certain, that that is true in the U.K. Too. ...Read more
Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more
Can be: Most colon cancers relate more to lifestyle than inheritance but some patients do have an inherited predisposition, be it in the setting of multiple polyps (like fap or myh) or not (lynch syndrome). Families with this have early onset colon cancer and other cancers as well. Talk to your doc about this to see if you need to visit a specialist in inherited malignancies. Remember to live healthy. ...Read more
Some colon cancers:
Are hereditary. Vast majority are not. The two common hereditary forms of colon cancer are familial adneomatous polys and lynch syndrome. Let me reiterate that hereditary colon cancers are a minority. See this site for more info.
http://www. Mskcc. Org/cancer-care/hereditary-genetics/inherited-risk-colorectal. ...Read more
Family risk: You will want to get colonoscopy from time to time starting soon. Your family members may also be checked for genetic problems such as HPNCC and familial polyposis; if they are affected, you may be checked as well. Getting 'scoped frequently greatly diminishes your risk of dying of this illness. ...Read more
I mean if chemotherapy does not work fir metastic colon cancer, can anything be done, any new drugs?
Yes: Depending where mets are, direct therapy can be offered resecting lung lesions locally, using chemoembolization for lesions in liver and hyperthermic perfusion for peritoneal seeding. Immunotherapy for VEGF and epidermal growth factors can also be employed as well as new drugs in Phase II-III such as mAbs targeting post translational modification of MUC5ac and CEAcam 5, 6`oncofetal proteins/ ...Read more
If there's hereditary predisposition of colon cancer how often should a person do colonoscopy and wha are the risk factors? And What is polyposis test?
Colon CA/screening: ACS screening for families that have a strong history. There are families that have predisposition to develop color and rectal CA. They say screening should start 10 yrs prior to the family members Dx. Say mom Dx at 40, screening would start at 30 in her family. Once you've had the first scope re can be made on the frequency, every 3 to 5 yrs depending on number of members Dx. ...Read more
Are there any new cancer drugs for colon cancer spread to the liver? My father is very ill and needs help.
Consider new trials: If I were in your father's position, I would consider being in a research trial (if one is available) for metastatic colon cancer. None of the approved therapies for this is curative; they are all palliative. I would probably favor something with an immune-based approach rather than a cell poison, if any such trial is available. This is just a personal preference I'm voicing. ...Read more
Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed?
Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more
Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets? Is it a risky drug
Slight benefit: Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30, 000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems. ...Read more
61Y old, colon cancer stage 2b, 3cycles of FOLFOX and she develops dyspnea 3-4days after chemo, could it be drug-induced pneumonitis? Onco says there is no such side effect for folfox regimen, but I've read the articles. Should we take this seriously?
Here are some...: Dyspnea denotes you need oxygen resulting from poor transporting oxygen from lungs to the blood. What is the underlying reason for this? You have to be evaluated so to find out what may cause short of breath in addition to a possible drug-induced pneumonitis. How to sort the related things for good care? Follow instructions in https://ebettercare. Com/feel-become-sick/. Thereby, you can work better ...Read more
Unpredictable: Colon cancer spread to local lymph nodes and then on to other organs such as liver, lungs, bones. It can spread through the blood vessels or locally to other organs such as kidneys, prostate, etc. Rate of spread is unpredictable at present and likely depends on growth factors, cancer differentiation, and unknown factors. Of cancers that comeback after surgery, most (80%) do so within 3 years. ...Read more
Blockage/Bleeding: Depending on their size and location, colon cancers may cause the above problems. The bleeding tends to be very slow, like a dripping faucet, and may not be evident by sight. Obstruction can cause a change in bowel habits (constipation, pencil-thin stools) and/or bloating. Like any cancer, there is the potential to spread to other organs, which may cause fatigue, loss of appetite, wt loss, etc. ...Read more
Depends: Early on there may be no effect. As the disease progresses undiagnosed, you may develop a change in bowels, blood in stool, abdominal pain, weight loss, loss of appetite, lethargy, loss of stamina, bowel obstruction, shortness of breath, anemia, early diagnosis in high risk patients or regular colonoscopies is the best way to avoid all of the above. ...Read more
...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). ...Read more