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Doctor insights on: Medicine For Granulomatosis

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What is wegner's granulomatosis?

Serious condition: This is a very rare disease which is a form of vasculitis (inflammation of the blood vasculitis) it commonly causes, sinusitis, has associated lung nodules and is associated with varying degrees of kidney damage which can lead to kidney failures. But it is treatable, usually requiring chemotherapy (although it is not cancerous!). ...Read more

Dr. Qamar Khan
44 Doctors shared insights

Granulomatosis (Definition)

A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive ...Read more


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What is wegener's granulomatosis?

What is wegener's granulomatosis?

Wegener's: Granulomatosis is an incurable form of vasculitis (inflammation of blood vessels) that affects the nose, lungs, kidneys, and other organs. ...Read more

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What are symptoms of wegener's granulomatosis?

What are symptoms of wegener's granulomatosis?

See details: The most common presenting symptom is a chronic sinusitis but there can be numerous other issues associated with wegener's including arthritis, pneumonia, eye problems, kidney disease and cardiac and neurologic issues. ...Read more

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Please advise what is wegener's granulomatosis?

Please advise what is wegener's granulomatosis?

Immune vasculitis: The antobodies found in the test and that cause the disease are directed against an antigen within neutrohils. Untreated, Wegener's (granulomatous angiitis for those who cannot forgive Dr. Wegener's being a German during WWII) is fatal. Nowadays it can be managed using cyclophosphamide and/or perhaps other powerful agents and most people eventually recover. ...Read more

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What are the tests for wegener's granulomatosis?

What are the tests for wegener's granulomatosis?

ANCA and biopsy: The most useful blood test is an anca with titer and pattern, and pr3/mpo confirmation. Biopsy of the affected tissue is also important. Imaging studies of the lungs and sinuses can be useful as well as blood and urine tests looking for kidney damage. Finally, EMG might be needed if there is concern for nerve damage. ...Read more

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What is the definition or description of: granulomatosis?

What is the definition or description of: granulomatosis?

Granulomatosis is: A process associated with a tissue reacton involving monocytes and tissue macrophages. Clasically this was seen in infections, like tuberculosis and some fungal processes. It is also seen and inflammatory and reactive processes such as sarcoidosis. ...Read more

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What is the definition or description of: Wegener's granulomatosis?

Wegener's granulomat: Wegener's granulomatosis (Granulomatosis with polyangiitis) causes vasculitis (inflammation blood vessels of nose, sinuses, throat, lungs & kidneys). See: http://www. Mayoclinic. Org/diseases-conditions/granulomatosis-with-polyangiitis/symptoms-causes/dxc-20167228 ...Read more

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What are the common symptoms associated with wegener's granulomatosis?

What are the common symptoms associated with wegener's granulomatosis?

Rash sinus lung: It is called polyangiitis with granulomatosis and is different in different people. This problem is caused by inflammation in the blood vessels which go everywhere in the body. Common symptoms include rash, sinus inflammation, lung problems which can be manifest by a cough. The kidney can be involved also but often this is asymptomatic. We can see other sites like the eyes, nose, etc. ...Read more

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What is lymphomatoid granulomatosis?

What is lymphomatoid granulomatosis?

Granulomatosis: It is a lymphoproliferative disorder (lymphomatoid means lymphoma-like). The word granulomatosis denotes one of its microscopic character, polymorphic lymphoid infiltrates and focal necrosis within it. It usually involves lung, skin, and central nervous system. It is caused by the epstein barr virus (same virus causes mono). No proven treatment but research trials are being done at nih. ...Read more

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What is wegener's granulomatosis vasculitis?

What is wegener's granulomatosis vasculitis?

See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more

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Could a bronchoscopy tell what caused wegener's granulomatosis?

Could a bronchoscopy tell what caused wegener's granulomatosis?

No it cannot: A bronchoscopy is useful for identifying that wegener's is affecting the lungs but it will not tell you the cause. Wegener's is in a class of conditions known as autoimmune. This is where the body does not recognize its own cells as being "self". In turn an immune response causes inflammation in the lungs, eyes and sinuses (the classic locatioins in the body to be affected by wegeners). ...Read more

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Causes of wegeners granulomatosis and treatment?

Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more

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I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis

I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis

Anemia? Cause? Chemo: Anemia can be caused by blood loss or impaired production of red cells. Wegner's often requires treatment with a chemotherapy drug which can also be the cause of Anemia. Your treating doctor should be able to explain all this to you. Are you taking treatment for your Wegner's Gran.??? ...Read more

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Please tell me what orofacial granulomatosis is?

Please tell me what orofacial granulomatosis is?

See details: This is an inflammatory condition effecting the face and lips. It is most common in the early adult years. Occasionally there may also be swelling or burning of the tongue or gums. It seems to occur more commonly in patients with Crohn's disease and sarcoidosis. However, the cause is unknown. TNF agents such as Remicade (infliximab) are now considered the treatment of choice. ...Read more

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What's a good description of wegener's granulomatosis vasculitis?

Systemic vasculitis: Wegener's is a systemic vasculitis associated with the presence of specific blood tests known as a canca or pr3 antibodies. It usually presents as chronic sinusitis and more rarely pneumonia but can effect other areas of the body especially the kidneys, eyes, heart and nervous system. It is very serious but newer medications have provided effective treatment in most cases. ...Read more

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Does anyone have information about wegener's granulomatosis vasculitis?

Attacks organs: Wegener's granulomatosis (wg), also known as recently granulomatosis with polyangiitis results in inflammation of blood vessels vasculitis. Wg mainly affects nose, lungs, kidneys and other organs. Treatment is long-term immunosuppression to reduce antibodies which are thought to "attack" the medium and small blood vessels. Dr. Friedrich wegener described the disease in 1936. ...Read more

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Pathology of my gallbladder showed granulomatosis is this likely to be in other parts of the body?

Pathology of my gallbladder showed granulomatosis is this likely to be in other parts of the body?

Granulomatosis of GB: Are you sure its granulomatosis or is it adenomyomatosis. If it's the latter don't worry, if there are multiple granulomas than this can have many causes and would be unlikely that it was isolated to the gallbladder. The causes of granulomas include tb, histoplasmosis, sarcoidosis, to name a few of the most common. ...Read more

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Sister just diagnosed with wegener's granulomatosis, she has much pain No kidney damage noted, what is her prognosis?

Sister just diagnosed with wegener's granulomatosis, she has much pain No kidney damage noted, what is her prognosis?

No kidney damage: Prognosis is favorable without kidneys being affected. But lungs should certainly be watched very closely. Treatment options are favorable. Please ask her to work on stress management. This is vital as stress-emotional/physical/situational-can make disease worse. This is not theoretical. This is fact. ...Read more

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Will wegener's granulomatosis kill me if I don't get treatment?

Will wegener's granulomatosis kill me if I don't get treatment?

Yes: Wegener's will not go away. It might take time but will ultimately cause severe lung and kidney problems, and death. Treatment can be very effective. ...Read more

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Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?

Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?

Uncommon problems: ...Like wegener's require someone with experience to manage all the myriad manifestations and potential problems (how's that for alliteration) that can come with the disease or its treatment. Its possible but unlikely that your regular doctor has such experience, if I had wegener's I would be looking to at least have my doctor consult with someone who sees this problem frequently. ...Read more

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Husband diagnosed with wegener's granulomatosis. Will his lung & kidney function return to normal?

Husband diagnosed with wegener's granulomatosis. Will his lung & kidney function return to normal?

Chance: In the past, wegener's granulomatosis was usually fatal. Currently, we have new and excellent treatment for the disease and some patients with kidney and lung disease have gone into remission. That does not always mean that the lung or kidney function will be completely normal but the disease progression can be stopped in some cases. ...Read more

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Can breast lump be caused by wegener's granulomatosis? What are the other symptoms?

Can breast lump be caused by wegener's granulomatosis? What are the other symptoms?

No, not likely: Wegner's causes nasal and sinus problems and respiratory symptoms like cough and lung nodules. It affects kidneys which shows up as rising creatinine and abnormal urinalysis. ...Read more

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What is the disease wegeners granulamatosis in kids?

What is the disease wegeners granulamatosis in kids?

WG: Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed (called vasculitis). This limits blood flow to tissues and can affect any organ. WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. Its cause is unknown. ...Read more

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Has anyone ever heard of the disease wegeners granulamatosis?

Has anyone ever heard of the disease wegeners granulamatosis?

Yes: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more