Doctor insights on:
Medicine For Granulomatosis
Serious condition: This is a very rare disease which is a form of vasculitis (inflammation of the blood vasculitis) it commonly causes, sinusitis, has associated lung nodules and is associated with varying degrees of kidney damage which can lead to kidney failures. But it is treatable, usually requiring chemotherapy (although it is not cancerous!). ...Read more
Immune vasculitis: The antobodies found in the test and that cause the disease are directed against an antigen within neutrohils. Untreated, Wegener's (granulomatous angiitis for those who cannot forgive Dr. Wegener's being a German during WWII) is fatal. Nowadays it can be managed using cyclophosphamide and/or perhaps other powerful agents and most people eventually recover. ...Read more
ANCA and biopsy: The most useful blood test is an anca with titer and pattern, and pr3/mpo confirmation. Biopsy of the affected tissue is also important. Imaging studies of the lungs and sinuses can be useful as well as blood and urine tests looking for kidney damage. Finally, EMG might be needed if there is concern for nerve damage. ...Read more
It is not: It is an autoimmune illness that strikes at random. ...Read more
Rash sinus lung: It is called polyangiitis with granulomatosis and is different in different people. This problem is caused by inflammation in the blood vessels which go everywhere in the body. Common symptoms include rash, sinus inflammation, lung problems which can be manifest by a cough. The kidney can be involved also but often this is asymptomatic. We can see other sites like the eyes, nose, etc. ...Read more
Granulomatosis: It is a lymphoproliferative disorder (lymphomatoid means lymphoma-like). The word granulomatosis denotes one of its microscopic character, polymorphic lymphoid infiltrates and focal necrosis within it. It usually involves lung, skin, and central nervous system. It is caused by the epstein barr virus (same virus causes mono). No proven treatment but research trials are being done at nih. ...Read more
See details: It is a form of vasculitis effecting medium sized arteries and associated with a positive canca blood test. It usually begins as chronic sinusitis but with time can effect many other organ systems including eyes, heart, kidneys, joints, lungs and the nervous system. There are very effective treatments available. ...Read more
No it cannot: A bronchoscopy is useful for identifying that wegener's is affecting the lungs but it will not tell you the cause. Wegener's is in a class of conditions known as autoimmune. This is where the body does not recognize its own cells as being "self". In turn an immune response causes inflammation in the lungs, eyes and sinuses (the classic locatioins in the body to be affected by wegeners). ...Read more
Autoimmune disease: Like all autoimmune diseases, the cause is not really known, but likely a combination of genetic factors and environmental exposures (e.g., infections, chemicals, pollutants). Treatment depends on how severe disease it is. Typically steroids (e.g. Prednisone) and if severe, Cytoxan or rituxan (rituximab). If limited disease (just nasal/upper airway involvement), Methotrexate may be sufficient. ...Read more
I have a low HGB, Low HCT, High Mono and Low calcium? What could this represent? I have Wegener’s Granulomatosis
Anemia? Cause? Chemo: Anemia can be caused by blood loss or impaired production of red cells. Wegner's often requires treatment with a chemotherapy drug which can also be the cause of Anemia. Your treating doctor should be able to explain all this to you. Are you taking treatment for your Wegner's Gran.??? ...Read more
See details: This is an inflammatory condition effecting the face and lips. It is most common in the early adult years. Occasionally there may also be swelling or burning of the tongue or gums. It seems to occur more commonly in patients with Crohn's disease and sarcoidosis. However, the cause is unknown. TNF agents such as Remicade (infliximab) are now considered the treatment of choice. ...Read more
Systemic vasculitis: Wegener's is a systemic vasculitis associated with the presence of specific blood tests known as a canca or pr3 antibodies. It usually presents as chronic sinusitis and more rarely pneumonia but can effect other areas of the body especially the kidneys, eyes, heart and nervous system. It is very serious but newer medications have provided effective treatment in most cases. ...Read more
Attacks organs: Wegener's granulomatosis (wg), also known as recently granulomatosis with polyangiitis results in inflammation of blood vessels vasculitis. Wg mainly affects nose, lungs, kidneys and other organs. Treatment is long-term immunosuppression to reduce antibodies which are thought to "attack" the medium and small blood vessels. Dr. Friedrich wegener described the disease in 1936. ...Read more
Pathology of my gallbladder showed granulomatosis is this likely to be in other parts of the body?
Granulomatosis of GB: Are you sure its granulomatosis or is it adenomyomatosis. If it's the latter don't worry, if there are multiple granulomas than this can have many causes and would be unlikely that it was isolated to the gallbladder. The causes of granulomas include tb, histoplasmosis, sarcoidosis, to name a few of the most common. ...Read more
Sister just diagnosed with wegener's granulomatosis, she has much pain No kidney damage noted, what is her prognosis?
No kidney damage: Prognosis is favorable without kidneys being affected. But lungs should certainly be watched very closely. Treatment options are favorable. Please ask her to work on stress management. This is vital as stress-emotional/physical/situational-can make disease worse. This is not theoretical. This is fact. ...Read more
Friend has disseminated histoplasmosis and wegener's granulomatosis. What is the treatment for both of them at the same time.
Should I see a specialist for wegener's granulomatosis, or can my regular doctor take care of it?
Uncommon problems: ...Like wegener's require someone with experience to manage all the myriad manifestations and potential problems (how's that for alliteration) that can come with the disease or its treatment. Its possible but unlikely that your regular doctor has such experience, if I had wegener's I would be looking to at least have my doctor consult with someone who sees this problem frequently. ...Read more
Husband diagnosed with wegener's granulomatosis. Will his lung & kidney function return to normal?
Chance: In the past, wegener's granulomatosis was usually fatal. Currently, we have new and excellent treatment for the disease and some patients with kidney and lung disease have gone into remission. That does not always mean that the lung or kidney function will be completely normal but the disease progression can be stopped in some cases. ...Read more
I'm 33, 3 c-sections tubes tied in 2006, I also have Wegners Granulomatosis, chemotherapy within the next week. Don't remember last period Pregnant????
What specialty should I look for in a doctor to treat my wegener's granulomatosis and rheumatoid arthritis? I believe that my current rheumatologist is doing a fair job. However; the few times that I am able to actually see him and not his p.A. I feel put
Rheumatologist: You are seeing the correct physician - discuss your ambivalence with him. I agree the pa should not be your point of care. ...Read more
WG: Wegener’s granulomatosis (WG) is a rare disease that causes the walls of blood vessels to become inflamed (called vasculitis). This limits blood flow to tissues and can affect any organ. WG is a type of autoimmune disease. This means the body’s immune system attacks its own tissues. Its cause is unknown. ...Read more
Yes: Wegener's granulomatosis with polyangiitis is an incurable form of vasculitis (inflammation of blood vessels) that affects the lungs, kidneys, and other organs. Due to its organ damage, it is life-threatening and requires long-term immunosuppression. Five-year survival is up to 87%, with some of the mortality due to toxicity of treatment. Since that is an average figure, some will live longer. ...Read more