Doctor insights on:
Medicine For Graft Versus Host Disease
Mainstays of therapy: for GVHD are corticosteroids; either systemic (prednisone) or topically, e.g triamcinolone. Cyclosporine and tacrolimus help minimize corticosteroid exposure. Sirolimus and mycophenylate mofetil are effective, as are methotrexate and azathioprine in refractory cases. B-cell therapies such as rituximab and bortezomib are promising. PUVA and ECP are light therapies with less systemic side effects. ...Read more
There can be many...: Acute GVHD presents as a skin rash, gut symptoms (nausea or diarrhea) or jaundice. Chronic GVHD commonly causes dry eyes and dry mouth but they can also get quite sore. More serious symptoms of chronic GVHD include sclerosis (scarring or thickening) of the skin, or reduced flexibility due to connective tissue inflammation (fascitis). Pulmonary airflow obstruction may cause shortness of breath. ...Read more
GVHD: occurs when bone marrow stem cells and/or immune cells have been engrafted from one individual into another. Except in identical twins, differences in cellular antigens cause engrafted cells to react against the host tissues and cause an inflammatory injury. Acutely, symptoms may affect the skin, liver, or gut; whereas chronic GVHD may affect the eyes, mouth, fascia, and lungs. ...Read more
A healthy diet: is important for GVHD patients, but it may not be much different than for the rest of us. If the mouth or gut is affected, then the key is to find foods the patient can tolerate. Sometimes simple, easy to digest foods are best. If a GVHD patient requires corticosteroid treatment (prednisone) then a healthy diet should be balanced by exercise to prevent weight gain and loss of muscle mass. ...Read more
Cellular immunity: Graft vs. host disease (GVHD) occurs when T lymphocytes from a donor cause inflammation in the normal tissues of a patient. This is a common side effect of allogeneic bone marrow transplants because billions of T cells are infused along with the bone marrow stem cells. It can also occur as a rare, unintended consequence of blood transfusion in Hodgkins patients. ...Read moreSee 1 more doctor answer
GVHD is a reaction..: of engrafted immune cells against the patients healthy tissues. It leads to inflammation and side effects in a variety of tissues. Rejection is the opposite. It is a reaction of the patients immune system against the engrafted cells. In the case of a bone marrow transplant, rejection would cause disappearance of the cells in the marrow and a drop in blood cell production. ...Read more
Looking for top specialist for overlapping graft vs host disease. Husband suffering from steroid refractory skin gvhd. Nothing works. ?
What other diseases/infections am I at risk for when getting a cadaver tendon graft? (I know the chances are very low, I would still like to know)
Hepatitis: There's talk of both B and C having been transmitted. Nobody knows whether West Nile, prion disease, or HTLV-I or HTLV-2 can be transmitted. ...Read more
Is it true that with bone grafting, all-on-four and etc, mostly anyone can get dental implants even if they lost teeth from gum disease?
Limitations: There are limitations to all treatments. For example, you can get periodontal disease around implants. Please see your Dentist for an evaluation as to whether implants and crowns or implant supported dentures would be applicable for your situation. Your Dentist may recommend teaming with an Oral Surgeon or Periodontist, or may recommend that you see a Prosthodontist. Go for exam and advice. ...Read moreSee 3 more doctor answers
NO: The grafting material, unless it is your own bone, usually only provide a scaffold for your blood vessel to proliferating and bring in your own bone cell, differentiate, and mature into your bone. Anti rejection drug applied more for using a live graft (an organ, bone marrow, etc.) and assuming its function. Thus anti rejection drug is not prescribed for bone graft procedure. ...Read moreSee 2 more doctor answers
I have grafting surgery for 2nd and 3rd toe syndectyly on 22nov.But healing isnot started & at some area skin is removed, sugst fast healing medicines?
Can the extraction of an upper back molar tooth without bone grafting that resulted in a sinus droop commonly lead to a TMJ disorder?
Extractions and TMJ: Not the extraction per se, but your having to open widely to get surgical access to the area can cause muscle or TMJ tenderness for a period immediately after the surgery but it would not likely cause a TMJ disorder to develop at a later time. ...Read moreSee 8 more doctor answers
Sure, lots.: Next question? Seriously, it depends what you want to know. A piece of skin is taken from a "donor" area and grafted onto the treatment area, usually when skin can't be stretched enough to close a wound primarily. They are also used to treat severe burns, where lots of skin area has been destroyed. Grafting should only be done by someone with special training and expertise. ...Read more
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