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Doctor insights on: Medicine For Graft Versus Host Disease

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Are there any new treatments or drugs that can help with graft versus host disease?

Are there any new treatments or drugs that can help with graft versus host disease?

Mainstays of therapy: For GVHD are corticosteroids; either systemic (prednisone) or topically, e.g triamcinolone. Cyclosporine and tacrolimus help minimize corticosteroid exposure. Sirolimus and mycophenylate mofetil are effective, as are methotrexate and azathioprine in refractory cases. B-cell therapies such as rituximab and bortezomib are promising. PUVA and ECP are light therapies with less systemic side effects. ...Read more

Graft (Definition)

Tissues from one location are transferred to another. Also refers to ...Read more


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What are the symptoms of graft-versus-host disease?

There can be many...: Acute GVHD presents as a skin rash, gut symptoms (nausea or diarrhea) or jaundice. Chronic GVHD commonly causes dry eyes and dry mouth but they can also get quite sore. More serious symptoms of chronic GVHD include sclerosis (scarring or thickening) of the skin, or reduced flexibility due to connective tissue inflammation (fascitis). Pulmonary airflow obstruction may cause shortness of breath. ...Read more

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What is the medical definition of graft-versus-host disease?

GVHD: Occurs when bone marrow stem cells and/or immune cells have been engrafted from one individual into another. Except in identical twins, differences in cellular antigens cause engrafted cells to react against the host tissues and cause an inflammatory injury. Acutely, symptoms may affect the skin, liver, or gut; whereas chronic GVHD may affect the eyes, mouth, fascia, and lungs. ...Read more

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What is an appropriate diet for someone with graft-versus-host disease?

What is an appropriate diet for someone with graft-versus-host disease?

A healthy diet: Is important for GVHD patients, but it may not be much different than for the rest of us. If the mouth or gut is affected, then the key is to find foods the patient can tolerate. Sometimes simple, easy to digest foods are best. If a GVHD patient requires corticosteroid treatment (prednisone) then a healthy diet should be balanced by exercise to prevent weight gain and loss of muscle mass. ...Read more

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Hodgkins lymphoma graft-versus-host disease, what is this?

Cellular immunity: Graft vs. Host disease (GVHD) occurs when T lymphocytes from a donor cause inflammation in the normal tissues of a patient. This is a common side effect of allogeneic bone marrow transplants because billions of T cells are infused along with the bone marrow stem cells. It can also occur as a rare, unintended consequence of blood transfusion in Hodgkins patients. ...Read more

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Can radiology be used to diagnose graft-versus-host disease?

Physical examination: ...and biopsies are the mainstay of diagnosis of graft vs. Host disease. Radiology is used mostly to exclude other causes of symptoms, such as an ultrasound of the liver to exclude biliary obstruction, or CT of the chest to exclude infection. ...Read more

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What is the difference between graft-versus-host disease and rejection?

GVHD is a reaction..: Of engrafted immune cells against the patients healthy tissues. It leads to inflammation and side effects in a variety of tissues. Rejection is the opposite. It is a reaction of the patients immune system against the engrafted cells. In the case of a bone marrow transplant, rejection would cause disappearance of the cells in the marrow and a drop in blood cell production. ...Read more

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How serious are someone's chances of getting graft vs. Host disease if I get a donated kidney?

How serious are someone's chances of getting graft vs. Host disease if I get a donated kidney?

Very small: It is very rare to develop gvhd with a kidney transplant. It is more common with bone marrow transplant and intestinal /multivisceral transplantation. ...Read more

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Looking for top specialist for overlapping graft vs host disease. Husband suffering from steroid refractory skin gvhd. Nothing works.?

Looking for top specialist for overlapping graft vs host disease. Husband suffering from steroid refractory skin gvhd. Nothing works.?

GvHD can be: Challenging. Photophoresis can be a nice adjunct if is available at your treatment center. This is a complex area and details of past therapy needed to give specific thoughts. ...Read more

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Is it typical to get graft vs. Host digestive problems in first 90 days after bone marrow transplant? How does this affect long term prognosis?

Yes: It can happen within first 3 months or after. Graft vs host disease that is not too severe can be a sign of the graft vs leukemia effect but severe gvhd can itself cause mortality. ...Read more

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Wanted to know if dental bone grafts work for peridontal disease?

Wanted to know if dental bone grafts work for peridontal disease?

Usually does...: Bone grafting is indicated for loose teeth due to a periodontal disease, but the teeth would have to be free of infection and stabilized with a fixed splint if the graft is to be successful. ...Read more

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What other diseases/infections am I at risk for when getting a cadaver tendon graft? (I know the chances are very low, I would still like to know)

Hepatitis: There's talk of both B and C having been transmitted. Nobody knows whether West Nile, prion disease, or HTLV-I or HTLV-2 can be transmitted. ...Read more

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I have receding gums. Don't have period disease, don't want gum grafting. Dr wants to put filling above canine in notch. Is this a good plan? Should I?

See below: Ask your dentist or periodontist about the Pin Hole technique, site unseen it is hard to comment but this new technique may be more beneficial that grafting. ...Read more

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Is it true that with bone grafting, all-on-four and etc, mostly anyone can get dental implants even if they lost teeth from gum disease?

Is it true that with bone grafting, all-on-four and etc, mostly anyone can get dental implants even if they lost teeth from gum disease?

Limitations: There are limitations to all treatments. For example, you can get periodontal disease around implants. Please see your Dentist for an evaluation as to whether implants and crowns or implant supported dentures would be applicable for your situation. Your Dentist may recommend teaming with an Oral Surgeon or Periodontist, or may recommend that you see a Prosthodontist. Go for exam and advice. ...Read more

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Does a person who had a bone graft have to take anti rejection drugs?

Does a person who had a bone graft have to take anti rejection drugs?

NO: The grafting material, unless it is your own bone, usually only provide a scaffold for your blood vessel to proliferating and bring in your own bone cell, differentiate, and mature into your bone. Anti rejection drug applied more for using a live graft (an organ, bone marrow, etc.) and assuming its function. Thus anti rejection drug is not prescribed for bone graft procedure. ...Read more

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I have grafting surgery for 2nd and 3rd toe syndectyly on 22nov. But healing isnot started & at some area skin is removed, sugst fast healing medicines?

I have grafting surgery for 2nd and 3rd toe syndectyly on 22nov. But healing isnot started & at some area skin is removed, sugst fast healing medicines?

Relax: Healing takes time. Usually at least 4-6 weeks to heal the incisions then longer to flatten out the scar. If your healing is delayed there are lots of wound care products that can help. Talk to your doctor or seek out a wound care center. ...Read more

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Can the extraction of an upper back molar tooth without bone grafting that resulted in a sinus droop commonly lead to a TMJ disorder?

Can the extraction of an upper back molar tooth without bone grafting that resulted in a sinus droop commonly lead to a TMJ disorder?

Extractions and TMJ: Not the extraction per se, but your having to open widely to get surgical access to the area can cause muscle or TMJ tenderness for a period immediately after the surgery but it would not likely cause a TMJ disorder to develop at a later time. ...Read more

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What is an alloderm graft?

Synthetic graft.: Graft that is used to augment soft tissue or periodontal tissue in the mouth. ...Read more

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Anyone know about skin grafts?

Anyone know about skin grafts?

Sure, lots.: Next question? Seriously, it depends what you want to know. A piece of skin is taken from a "donor" area and grafted onto the treatment area, usually when skin can't be stretched enough to close a wound primarily. They are also used to treat severe burns, where lots of skin area has been destroyed. Grafting should only be done by someone with special training and expertise. ...Read more

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Could nerve grafts restore potency?

Could nerve grafts restore potency?

Good thought: So far, no progress in this category, but a good idea. ...Read more

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Can you smoke after soft tissue graft?

Can you smoke after soft tissue graft?

Shouldn't: It will delay wound healing quite a bit. ...Read more

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What can cause alloderm graft failure?

What can cause alloderm graft failure?

It happens: Any time you have a graft done there is a chance of failure. It can be caused by many different factors ranging from an infection to rotten luck. I have seen grafts fail from time to time and sometimes we just have no idea what happened. If your doctor followed all the protocols your graft had a great chance of success but failure is always possible. ...Read more

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How long after skin grafts can I heal?

How long after skin grafts can I heal?

At least 3 weeks: It takes at least 3 weeks and closer to 3 months for skin grafts to achieve significant adherence to minimize the risk of shear or stress forces on the donor site and recipient sites. This may also be influenced by the thickness of the graft as well as the location of the graft. For exampe longer periods may be advised for the sole of the foot -. ...Read more

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Can you exaplin what is ovarian grafting?

Can you exaplin what is ovarian grafting?

Preserve your eggs: Ovarian grafting is an experimental technique that can be used to preserve your eggs for future fertility prior to chemotherapy, or radiation, or any treatment that can damage the eggs and ovaries. At this time, freezing eggs or embryos is a more reliable method to preserve your eggs and your fertility and may be a better option. Please speak with a specialist before you make a decision. ...Read more

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Can you tell me anything about skin grafts?

Yes: Skin grafts are very helpful after losing large amounts of skin. If there are areas that can not cover your body from burns, or other injuries skin can be removed from other parts of your body or cadeaver skin can be used to place over the uncovered area to protect your body. This usually works well for healing and allows a much better cosmetic look for the area needing to be covered. ...Read more

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How painful is it to have a soft tissue graft?

How painful is it to have a soft tissue graft?

Need more info: Soft tissue grafts are used for gum disease, hernias, breast reconstruction, bladder suspension to name but a few. As you can imagine, the postoperative pain can be quite different. Which specific use are you referring to? Thanks. ...Read more

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Can you get cosmetic correction for graft sites?

Several Options: Graft donor and recipient sites can be unsightly and may even cause functional restrictions. Multiple options can be available including treatment using co2 fractionated ablative laser or pulse dye laser, surgical correction through local or expanded flaps or regrafting of specific regions. Signficant research is on-going and more additional options may be available in the future. ...Read more

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Does anyone know the cost of a soft tissue graft?

Does anyone know the cost of a soft tissue graft?

(Very) expensive: The cost of surgical graft varies with the type of material and size of the mesh. Small pieces of synthetic mesh costs hundreds of $$; bio absorbable mesh costs thousands and the largest pieces can be as expensive as a small car. ...Read more

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Could you graft nerve endings to restored foreskin?

Could you graft nerve endings to restored foreskin?

Afraid not: Presume you had a skin graft to restore foreskin. Not possible to graft nerve endings into a graft. They would need to be connected to functional nerves in penile skin next to graft. This is technically impossible. ...Read more

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For how long does it take for nerve grafting to heal?

For how long does it take for nerve grafting to heal?

Nerve grafting: Nerve grafts typically heal in about two to three months however the nerve regeneration through the grafts can months and sometimes up to two years. ...Read more