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Doctor insights on: Medicine For Cushing Disease

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What is cushing disease?

What is cushing disease?

Disease vrs Syndrome: Cushing disease, which is hypercortisolism caused by an acth-secreting pituitary adenoma, is the most common cause of cushing syndrome, and is responsible for 60% to 70% of cases. Cushing syndrome is mainly caused by other sources of corticosteroids like the medicines dr prescribe to treat many conditions (prednisone, medrol, (methylprednisolone) solumedrol, (methylprednisolone) deposed rol, etc) commonly in copd, asthma, allergies. ...Read more

Dr. Lawrence Kessler
50 Doctors shared insights

Cushing Disease (Definition)

Cushing disease is excessive cortisol production due to an acth secreting pituitary adenoma. Acth stimulates the adrenals to produce excessive cortisol, leading to central obesity, lack of growth in children, high blood pressure, hyperglycemia, muscle weakness and skin fragility. It can also ...Read more


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What sort of disorder is cushing disease?

What sort of disorder is cushing disease?

Cushing's disease: Cushing's disease is a condition where the pituitary (tumor) is producing too much acth (adrenalcorticotropic hormone). This hormone stimulates your adrenal glands to produce extra cortisol (stress hormone) which in excess can cause a lot of metabolic problems. ...Read more

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What are the symptoms of cushing disease?

What are the symptoms of cushing disease?

Many symptoms: Symptoms / signs: truncal obesity (mr. Potatohead look), "moon" facies, thinning of skin, easy bruising, "buffalo" hump in upper back, purple stretch marks, hypertension, fatigue, psychiatric sx, insomnia, excess hair growth, muscle weakness and loss. Symptoms are often progressive and should prompt screening. ...Read more

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Difference between cushing disease and syndrome?

Difference between cushing disease and syndrome?

Disease vs. Syndrome: Hi. Cushing's disease is specifically hypercortisolism due to an ACTH-secreting pituitary adenoma. Cushing's syndrome is simply the clinical manifestations of hypercortisolism, and (once you know it's not pituitary) can be due to adrenal tumors (benign or malignant), exogenous glucocorticoid therapy, or a paraneoplastic syndrome (cancers that secrete ACTH or CRH). ...Read more

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What choices do I have for treating cushing disease?

What choices do I have for treating cushing disease?

Options: Cushing's disease is different than cushing's syndrome. Cushing's disease is caused by a tumor or enlargement (hyperplasia) of the pituitary gland. The best treatment is to take it out through surgery. If the surgery is incomplete, radiation treatment can then be used. Lastly, if these treatments are not successful, the adrenal glands may need to be removed to stop the production of cortisol. ...Read more

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What is the definition or description of: cushing disease?

What is the definition or description of: cushing disease?

ACTH secreting tumor: Cushing disease is excessive cortisol production due to an acth secreting pituitary adenoma. Acth stimulates the adrenals to produce excessive cortisol, leading to central obesity, lack of growth in children, high blood pressure, hyperglycemia, muscle weakness and skin fragility. It can also cause low bone density. ...Read more

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Is it bad luck or bad genes that made me develop cushing disease?

Is it bad luck or bad genes that made me develop cushing disease?

Not your fault: Quoting dr. Loh:primary cushing's syndrome is the result of an endocrine active mass of adrenal gland cells that become so not as a result of lifestyle habits (good or bad). It's not your fault, but fortunately often completely curable. There are secondary cushing's syndromes related to medications doctors give to treat certain conditions, and it becomes a balance of benefits vs. Risks. ...Read more

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Kids' favorite aunt came to visit. Told me she has cushing disease. What should I tell my children?

Kids' favorite aunt came to visit. Told me she has cushing disease. What should I tell my children?

Rarley hereditary.: Usually due to a small mass in the pituitary gland in the brain that screats high level of special hormone that increase the production of cortisol from the adrenal glands. It cause multiple problems it increase weight, blood glucose, blood pressure causes osteoporosis. It is rarely hereditary and should not worry the kids that they may get it. ...Read more

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What can I use for cushing disease if I don't have a doctor?

What can I use for cushing disease if I don't have a doctor?

Need a doctor: Cushing's disease is treated with surgery or prescription medications. There is no over the counter or natural/herbal way to treat this disease. It's a very difficult diagnosis to make and even with a doctor who specialized in this disease, it will take many tests to come up with a definitive diagnosis. ...Read more

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When I was little, my parents said I had cushing disease. I don't know many others who have had it. What is it?

When I was little, my parents said I had cushing disease. I don't know many others who have had it. What is it?

Excess cortisol: Cushing's disease is very uncommon. It is a pituitary tumor that makes a hormone (acth) that stimulates the adrenal gland to make excess cortisol. The treatment is pituitary surgery, sometimes followed by radiation and/or meds. Cushing's syndrome is excess cortisol from any cause - steroid use, adrenal mass or cushings disease. Symptoms are same-obesity, thin fragile skin, easy bruising, etc. ...Read more

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Symptoms wise difference between pcos & cushing disease.2 or 3 symptomes which occur only in cushing disease not in pcos?

Symptoms wise difference between pcos & cushing disease.2 or 3 symptomes which occur only in cushing disease not in pcos?

May appear similar: Both diseases can present with weight gain, hirsutism, acne, and irregular periods in women. However, cs usually includes symptoms such as easy bruising, sleep disturbances, decreased libido, a buff alo hump, and stretch marks, which are not present in pcos. Testosterone and cortisol levels may help distinguish between the two. You doctor can decide which tests are necessary. ...Read more

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My doctor diagnosed me with cushing disease. Just checking - what's the best treatment.?

Surgery: Cushings disease is due to a pituitary tumor that makes a hormone that stimulates cortisol production. Surgery is the treatment of choice, but additional treatment with radiation and medication is often necessary. ...Read more

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I have been using nose spray for approximately 45 years 2 or more times a day (like afrin (oxymetazoline) and 4-way) could I get cushing' disease and what other side e?

I have been using nose spray for approximately 45 years 2 or more times a day (like afrin (oxymetazoline) and 4-way) could I get cushing' disease and what other side e?

No: You cannot get cushings' syndrome, the result of taking large amounts of corticosteroids, from decongestant sprays like afrin. You can become and probably are dependent on these sprays, a condition called rhinitis medicamentosa. You also cannot get cushings' from using topical corticosteroid nasal sprays. The dose is just too low to cause such a side-effect. ...Read more

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How can we treat cushing's disease?

How can we treat cushing's disease?

Depends: Surgery 2 remove the pituitary tumor if possible. During the recovery process, u may need cortisol replacement treatments. Radiation treatment of the pituitary gland may also be used. If the tumor doesn't respond 2 surgery or radiation, u may get meds 2 stop ur body from making cortisol. Adrenal glands may need to be removed to stop the high levels of cortisol from being produced. ...Read more

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Why is cushing's disease or syndrome fatal?

Excess cortisol: Cushing's disease is excessive cortisol in the body from a pituitary tumor that leads to its secretion. Cushing's syndrome refers to the stigmata with excessive cortisol. This can be from the pituitary or administered by drs. Symptoms include hypertension, obesity, heart problems, sensitivity to infection. Cushing's disease/syndrome can be treated so it is not necessarily fatal, but it can be. ...Read more

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How do physicians diagnose cushing's disease?

How do physicians diagnose cushing's disease?

Labs and imaging: A lab draw or urine test can tell if your body is making too much cortisol. This is a condition called cushing's syndrome. Cushing's disease is cushing's syndrome caused by a pituitary tumor. Imaging studies (MRI) can locate this tumor. ...Read more

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How do I urge my doctor to look into cushing's disease?

How do I urge my doctor to look into cushing's disease?

Labs first: I agree with dr nguyen- just wanted to reiterate importance that imaging is not the first step. The physical exam and blood or urine tests will guide decision about whether imaging with ct or MRI is necessary. Premature imaging can lead to serious, unnecessary procedures and anxiety. ...Read more