Doctor insights on:
Medicine For Capecitabine Allergy
Allergies occur when your immune system is triggered by envirionmental factors it should ignore--for example, pollen in the air, or dander on a cat or dog--and creates cells to fight against them. An allergic reaction typically causes itching, congestion, or drainage, and ...Read more
Helps: Xeloda, (capecitabine) is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers including colorectal Ca. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the body and is employed as a form of adjuvant therapy that may help to enhance survival. In the face of metastasis, with combination drugs it may prolong survival by months. ...Read more
How fast does Xeloda (capecitabine) work on shrinking tumours and how would this drug cause you to vomit blood?
Xeloda (capecitabine) can shrink tumors in 3-4 weeks time.
It would rarely cause bleedding in the vomitus...It could only happen if it has caused severe mouth/throat ulcerations which is uncommom but it does occur in 1-2% of the patients taking xeloda (capecitabine). ...Read more
Mcrc patient aged 65. Drs not willing to Give any 5-FU drugs due to chest tightness. Tried Xeloda (capecitabine) n irinotecan. What can we do now?
Define met site.: Regardless of site and extent of mets, primary resection essential. This eliminates any other site of spread. PET/CT will determine met areas after primary removed. If as is usual, mets are to liver, microwave ablation, or chemo embolization or radioactive microspheres given to liver to control disease. Any pulmonary nodes removed thru thorascope. Most protocols contain 5FU (fluorouracil). ...Read more
Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed?
Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more
70 years male with stomach cancer metastasized to liver and bone, is this a good chemo drug combination (capecitabine+oxaliplatin+zoledronic acid)?
Chemo: If you can tolerate capecitabine, the regiment will be good for the type of cancer. Also, consider to check her2-neu receptor status of the cancer - as if her2-neu receptor is positive, Herceptin (trastuzumab) which is an inhibitor to the her2-neu receptor should be considered as one of treatment options. ...Read more
These are 2 options:
Xeloda (capecitabine) - is an oral chemotherapy drug that can be used for certain metastatic cancers alone or in combination with other chemotherapy drugs as palliative treatment.
Zometa - is used in a situation where cancer has spread to the bones. Its not chemotherapy but a bisphosphanate, a medication used to prevent further weakening of bones by cancer and prevent fractures.
In some situations both are given. ...Read more
Http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a699003.html
if any concern, please see your oncologist and discuss further with your md. ...Read more
Generally, how many times a week/month does an INR need to be taken when prescribed Xeloda (capecitabine) and warfarin?
Varies with time: At first, INR is usually checked every 3-4 days until a dose is found that keeps you in the appropriate INR range for 2 or more checks, then checks are spaced out to weekly. With a couple more normal checks, they can be moved to every 10-14 days, then ultimately if your dose is very stable over time and you do well at maintaining a consistent warfarin-diet, monthly checks are fine long-term. ...Read more
In certain cancer: Xeloda (capecitabine) is an oral chemo, which is a prodrug of 5-fluorouracil- a type of chemotherapy that has been used for many different cancers. Xeloda (capecitabine) is an effective chemotherapy for some cancers- such as gastrointestinal cancers (colon, rectal, stomach, esophageal etc), breast cancer- but not for all type of cancer. ...Read more
It may cause fatigue/weakness, nausea, vomiting, change in taste, supression to blood counts-anemia, low white blood cells, low platelet, rash/dryness/peeling skin of plams and soles, oral sore, infection, etc. Discuss further with your oncologist.
Read more here http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a699003.Html. ...Read more
Probably not: Occasionally, the cutaneous reaction may be severe. I suppose, in that situation, fingerprints may be lost temporarily. ...Read more
Different: Xeloda is oral chemotherapy while Avastin (bevacizumab) is a monoclonal antibody targeting vascular growth factor. Bevacizumab (avastin) is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor. It also helps with chemo by allowing entry into tumor microvascular structures while Xeloda helps to inhibit DNA synthesis ...Read more
NO: Faslodex (fulvestrant) is an anti estogen therapy -used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow)- is given by injecting medication into the muscle. Xeloda is an oral chemotherapy- which is a pro drug of 5fu. It is used to treat different kind of cancer such as- colon, esophagus, rectal, breast. They are not similar. ...Read more
Xeloda (capecitabine): What specific information do you want to know? Xeloda (capecitabine) is a pro drug of 5-fu (fluoro-uracil)- which is one of the oldest chemotherapy that has been widely used for the last 50 year or so. Xeloda (capecitabine) is an oral chemotherapy- used to treat different kind of cancer including- colon, rectal, esophageal, stomach, breast cancer. Open this link: http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a699003.Html. ...Read more
What happens if for mcrc, Xeloda (capecitabine) n irinotecan has failed? The person has about 3, 4 mets?
Not really: Having failed does not necessarily represent progression of metastasis but possibly no evidence of extensive disease progression. In such a case if disease is in liver isotope infusion or chemoembolization may help. If new lung lesions are seen, they may be amenable to resection and if progression has occurred newer immunotherapy approaches such as with Neo 102 can give better than 1 yr. Survival. ...Read more
If Xeloda (capecitabine) n irinotecan failed does this mean person with mcrc is chemotherapy resistant?
Maybe: The treatment for metastatic colorectal Ca also includes FOLFOX which includes the platinum drugs as part of the combo. If not yet taken one should consider this protocol. I usually obtain fresh tumor from bx to send for chemosensitization. If these fail, chemo with Erbitux or Avastin (bevacizumab) may prove beneficial. ...Read more
Xeloda (capecitabine) is a chemotherapy drug related to 5-fu. It is a tablet and is used by itself in the elderly and in combination with other drugs for breast cancer. It is relatively well tolerated.
Zometa is a bisphosphonate designed to strengthen bone like drugs for osteoporosis. In metastatic cancer its job is to reduce the liklihood of fracture and other problems in bone. ...Read more
An Oral Chemotherapy: Xeloda (capecitabine) is an oral chemotherapy drug, the most common side effects are diarrhea, nausea, hand-foot syndrome (redness, swelling, cracking of palms/soles) and like any chemotherapy may bring down your white blood cells. To prevent this you may take an anti diarrheal, anti emetic, b6, use a skin moisturizer and check your blood frequently. Not everyone experiences one of these symptoms. ...Read more
Varies: This varies among different patients. Half of the active drug is eliminated in approx 45 minutes from thebody- however, some drug levels are present in body tissues for many days. ...Read more
Possible Side Effect: Xeloda (capecitabine) is an oral chemotherapy drug, the most common side effects are diarrhea, nausea, hand-foot syndrome (redness, swelling, cracking of palms/soles) and like any chemotherapy may bring down your white blood cells. To prevent this you may take an anti diarrheal, anti emetic, b6, use a skin moisturizer and check your blood frequently. Not everyone experiences one of these symptoms. ...Read more
Xeloda (capecitabine) can cause varied side effects. Majority of patients experience skin toxicity in the form of dry skin which tends to become cracked and painful (it is called Hand foot syndrome because it is most marked on the palms and soles).
Some patients develop painful sores in the mouth (mucositis). Diarrhea is another common side effect. Some patients are genetically prone to very severe reactions. ...Read more