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Doctor insights on: Mayo Clinic Pernicious Anemia

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Can pernicious anemia be cured?

Can pernicious anemia be cured?

Not usually.: Classical pernicious anemia is caused by auto-antibodies against intrinsic factor-producing parietal cells of the stomach. Treatment is lifelong vitamin B12 administration, which is safer than using immunosuppressive medications that could lead to severe infections. Other kinds of B12 deficiency can possibly cured depending on the cause. ...Read more

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Is pernicious anemia life-shortening?

Is pernicious anemia life-shortening?

Should not be!: It did shorten lives. But with B12, there should be no shortening of life!!!!!!!!!!!!!!!!!!! ...Read more

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Could pernicious anemia shorten life?

Could pernicious anemia shorten life?

Probably no: If you have pernicious anemia you do not absorb B12 effectively. That is easily fixed with either B12 injections or large B12 oral doses daily. Unfortunately, patients with B12 deficiency often have other associated autoimmune issues that develop. In general though, pa alone will not shorten life as long as you treat it correctly. ...Read more

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What are the symptoms for pernicious anemia?

Fatigue: Caused by an anemia with large red blood cells! Reversible quickly with B12! ...Read more

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What are the causes of symptoms in pernicious anemia?

What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

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How to treat pernicious anemia?

How to treat pernicious anemia?

B-12 deficiency: Unless there is an intestinal parasite, we usually just do blood studies to confirm and supplement vitamin b-12 using 1000 mcg injected monthly, i.M. Some pts will absorb sufficient amounts by mouth or intranasal routes, but most efficient to inject. ...Read more

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Is there a cure for pernicious anemia?

Is there a cure for pernicious anemia?

Treatable: This condition can be well treated with life-long use of B12 injections or nasal sprays and results in normalisation of the blood counts. ...Read more

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Best way to get rid of pernicious anemia?

Vitamin B12: Go to your md or hematologist. Get started on vitamin B12 either by nasal inhalation (nascobal) or by injection. This shold be easy to treat. ...Read more

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Is cirrhosis related to pernicious anemia?

Is cirrhosis related to pernicious anemia?

No it is not!: Unless it is primary biliary cirrhosis, or autoimmune hepatitis. They are associated with true pernicious anemia. Alcoholic cirrhosis is not! ...Read more

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Does pernicious anemia cause high serum b12?

Does pernicious anemia cause high serum b12?

Low vitamin B12.: Pernicious anemia is a LOW vitamin B12 state. This occurs when the body fails to make enough of a specific protein to enable the body to absorb vitamin B12. This usually occurs when the immune system attacks a specific cell in the stomach that produces the needed protein. Since the body can't absorb vitamin B12 through the stomach it can be given in a shot and even under the tongue. ...Read more

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Since having pernicious anemia I get drunk quicker?

Maybe a little.: If you have a significant anemia with low red blood cells I suppose you could feel a little more woozy with a smaller amount of alcohol, but unless you are pretty anemic I would not expect this to be a signifiant effect. ...Read more

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Is there a link between pernicious anemia and cancer?

Possibly.: There appears to be some association between pernicious anemia and the risk of developing gastric cancer, but this is controversial. Pernicious anemia frequently develops with an autoimmune attack on certain gastric cells, which leads to vitamin B12 deficiency and later anemia. This autoimmune attack also leads to chronic gastritis, which can then progress to cancer. ...Read more

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Do doctors see a lot of patients with pernicious anemia?

Do doctors see a lot of patients with pernicious anemia?

Some: Pernicious anemia is due to malabsorption of vitamin b-12 from the GI tract. It is a form of low blood cell count with associated symptoms of fatigue, paleness, breathing difficulties, etc. While not very common, all such patients should be evaluated by their doctor to give treatment for the pernicious anemia if that is the only problem and to discover any other problem. ...Read more

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Does having pernicious anemia lead to fertility problems?

Yes indirectly: Pernicious anemia is a deficiency of vitamin B12 and or folate (folic acid) (another b vitamin) that can lead to significant medical problems many of which affect the nervous system. Folate (folic acid) is so critical to fetal neural development that the fda recommends that all women trying to conceive or pregnant take a Folic Acid supplement of 0.4 milligrams or 400 micrograms a day. ...Read more

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If I have pernicious anemia should I give birth naturally?

Best to see your OB: They will work with their hematology and perhaps GI colleagues to help guide decisions during your pregnancy. With modern medical and supportive care, I am not aware of a contraindications to natural childbirth in the setting of pernicious anemia. I suspect that you are already receiving folate (folic acid) supplementation from your doctors, which can ameliorate some pernicious anemia sequelae. ...Read more

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My mom gets pernicious anemia, so am I likely to get it later?

My mom gets pernicious anemia, so am I likely to get it later?

Pernicious Anemia: Pernicious anemia is not inheritated to my knowledge. It is usually caused by lack of the vitamins b 12 in diet (by vegetarians) or lack of intrinsic factors in autoimmune atrophic gastritis or in patients who had part of the stomach cut off for bariatric surgery (to reduce weight) or as surgical treatment for peptic or gastric ulcers (gastrostomy). ...Read more

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Is it possible for chronic gastritis to cause pernicious anemia?

Is it possible for chronic gastritis to cause pernicious anemia?

The two are linked: This finding goes back to 1964, believe it or not:

http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc1552204/? Page=1

there are autoimmune antibodies in both conditions, so while one might not cause the other, the two are related. ...Read more

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What causes pernicious anemia and what are some treatments for it?

What causes pernicious anemia and what are some treatments for it?

Low vitamin B12: Pernicious anemia is a condition in which the body is unable to absorb vitamin B12 through the stomach due to loss of a protein called intrinsic factor in the stomach. Treatment invovles replacing b! 2 through injections or nasal sprays- taking oral pills is ineffective. ...Read more

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What causes pernicious anemia and a mild increase in gamma globulin?

Pernicious anemia...: Is due to B12 def arising from loss of intrinsic factor production by parietal cells in the stomach and required for B12 absorption in the gut. Anything that produces B12 def can cause these symptoms. Classically, pa is one such diagnosis that is due to destruction of parietal cells by the immune system (ie., an autoimmune disorder). I suspect elevated igg is true, true and unrelated. See your dr. ...Read more

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What differences are there in megaloblastic anemia and pernicious anemia?

Pernicious = Vit B12: Megaloblastic anemia refers to any condition which causes large red blood cells (folate (folic acid) deficiency, vitamin B12 deficiency, etc.) pernicious anemia can be thought of as a *type* of megaloblastic anemia which is caused by vitamin B12 deficiency secondary to malabsorption. ...Read more

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What is the difference between pernicious anemia and megaloblastic anemia?

Big RBC: Pernicious anemia is deficiency of vitaminb12 due to autoimmune attack on cell of the stomach and antibody against intrinsic factor- presented with megaloblastic anemia. Pa is only one of the causes of megaloblastic anemia- however other causes that can cause def vitb12, or folate (folic acid) or other drug eg. Bactrim- that inhibits dna synthesis in RBC production also can cause megaloblastic anemia. ...Read more

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Can you please describe the best ways for getting rid of pernicious anemia?

Treatment: Pernicious anemia is the result of loss of B12 in your system. It can result from severe dietary restrictions, genetic or bowel disorders, bowel resections and bariatric surgery. You must be treated for the cause and the effects of B12 deficiency, which should prevent anemia and neurologic damage from these problems. A simple blood test for B12 level is available. ...Read more

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What are the causes of pernicious anemia and what are the treatments for it?

Classical: Pernicious anemia (b12 deficiency) occurs when a cofactor in the stomach, intrinsic factor, does not do its job. If is needed for B12 absorption. ...Read more

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Can long untreated pernicious anemia give you the same symptoms of aplastic anemia with out actually having it.?

PA: Is due to deficiency of B12 and/or folate (folic acid). Anemia is anemia, whatever the cause. If due to folate (folic acid) deficiency B12 must also be given or you will wind up with a nasty compliocation. ...Read more

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What else can help with pernicious anemia other than b12 injections? Have read that in UK the type of b12 used in injections isn't very good. True?

Bunk: Stop reading internet disinformation. Back in the old days, pernicious anemia assured a terrible lingering death preceded by insanity. The very fact that "natural healing" types make up stuff about the injections that have saved millions of lives show how successful they are. Forgive my frankness and remember that the law requires your physician to be honest while crooks have no accountability. ...Read more

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I have pernicious anemia. I am supposed to take B12 shots. I have some left expired 8/12. Is it OK to take? And what size syringe. 1cc intramusc

B12: Expired medications should not be taken. They may be less potent, or with injectables, may have increased risk of contamination ...Read more

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Is pernicious anemia helped by B12 vitamins as well as as B12 injections?

Most true B-12: Deficiencies are due to loss of "intrinsic factor", secreted by the stomach, it aids absorption, so if it is missing pills will not work. Shots of b-12, cyanocobalamine, are bright red, and are used for placebo effect in some instances. Most people have intrinsic factor, normal b-12 levels. ...Read more

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What is pernicious anemia?

Pernicious anemia: It's a condition which results in low vitamin B12 leading to anemia. The person affected with this condition needs the B12 supplement by injection route as oral absorption is impaired. ...Read more

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What is pernicious anemia?

B12 deficiency: It is an autoimmune disease in which your body develops antibodies against intrinsic factor and gastric parietal cells which are needed to absorb b12, a vital nutrient. These patients will need to get im injections of b 12 lifeterm since they cannot absorb B12 naturally from their diet. ...Read more

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How can I treat pernicious anemia?

How can I treat pernicious anemia?

Cobalamin therapy: Try a trial of vitamin B12 (cobalamin) first and have a physician to repeat lab to ensure adequate dose. Also it may need additional therapies for cobalamin deficiency due to underlying diseases involving intestine or pancreas. Please check for Folic Acid deficiency as well and this may be related to nutritional deficiency. If you are a vegetarian, please take vitamin B12 daily. ...Read more

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How is 'pernicious anemia' treated?

With B12!: Taken by injection, or with 2500 mcg oral B12. Can be associated with iron deficiency of gastric acid production is reduced! ...Read more

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How do you treat pernicious anemia?

Vitamin B-12: Pernicious anemia is a complicated disease, but the end result is that patients become deficient in vitamin b-12. Therefore, the treatment primarily involves b-12 supplementation. ...Read more

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What are the causes of pernicious anemia?

What are the causes of pernicious anemia?

Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray). ...Read more

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What is the definition or description of: pernicious anemia?

Due 2 B12 deficiency: It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily treatable with replacement therapy. ...Read more

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Does pernicious anemia run in families?

Rarely: Most cases of pernicious anemia are acquired due to immune destruction of the stomach cells which produce intrinsic factor. This results in poor absorption of B12 from food and patients get anemic as a result. Only rarely can children get this as a congenital causes. ...Read more

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Does methadone cause pernicious anemia?

Not likely: Methadone is a very strong opioid medication, with a long list of serious side effects. But pernicious anemia is NOT one of them.

Contact your doctor for specific information about your case, re your anemia and specific doses of methadone you are taking. Anemia may be related to other meds you are taking, or an underlying illness. Check with your MD. ...Read more

Pernicious Anemia (Definition)

A decrease in red blood cells when the body can't ...Read more


Dr. Steven Ginsberg
1,285 Doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more