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Doctor insights on: Mastocytosis Symptoms

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What are the symptoms of mastocytosis?

What are the symptoms of mastocytosis?

It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more

Dr. Brant Ward
43 doctors shared insights

Mastocytosis (Definition)

Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more


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Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

Is 'flushing' symptom heat felt all over the body suddenly? For mastocytosis?

No.: Flushing is the sudden occurrence of redness and heat on the face and upper trunk. When due to mastocytosis it is often accompanied by palpitations, low blood pressure, dizziness, chest pain, explosive diarrhea, nausea, or fatigue. Other things, such as rosacea, medicines, and food additives, can also start a flushing attack. ...Read more

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22yr female. Experience the following symptoms: angioedema, chronic urticaria, anaphylaxis, bone/muscle pain etc, is this systemic mastocytosis?

22yr female. Experience the following symptoms: angioedema, chronic urticaria, anaphylaxis, bone/muscle pain etc, is this systemic mastocytosis?

Serum tryptase level: You're certainly describing an entity that sounds histamine mediated but of course can be due to other causes and mediators. Does she have urticaria pigmentosa? Have you done a serum tryptase level? To my knowledge the one definitive diagnostic is a bone marrow bx. The other lab i look at to asses a histamine mediated process is anti high affinityfc epsilon receptor antibodies. Any meds? ...Read more

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What is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Does mastocytosis go away?

Does mastocytosis go away?

Usually: Most cases of cutaneous (just in the skin) mastocytosis start in childhood and will go away as a person gets older. Sometimes the spots may stay but the reactions from them (itching or hives when the spots are irritated) fade over time. Systemic mastocytosis (throughout the body and bone marrow) is much rarer, but usually will not go away. See as specialist in mastocytosis for more information. ...Read more

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Does mastocytosis go away?

Does mastocytosis  go away?

Skin problem: This is a skin disorder. I recommend asking a dermatologist this question. ...Read more

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How to control mastocytosis?

How to control mastocytosis?

Certain meds: Cutaneous masto can be treated with daily oral antihistamines or cromolyn applied to the skin, but sometimes may not need treatment. Systemic masto is usually treated with antihistamines, plus oral cromolyn for GI symptoms and epipen (epinephrine) for anaphylactic episodes. Aggressive forms may only respond to certain chemotherapy agents. See a specialist in masto for more information. ...Read more

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What does mastocytosis mean?

What does mastocytosis mean?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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What exactly is mastocytosis?

Too many mast cells: Mastocytosis is an overgrowth of mast cells, immune cells that release histamine and other chemicals upon activation. There are several forms, from small collections of cells in the skin (urticaria pigmentosa) to increased numbers in the bone marrow and throughout the body (systemic mastocytosis). Symptoms vary from hive-like reactions to recurrent anaphylaxis. See a specialist for more details. ...Read more

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Anyone diagnosed mastocytosis? How?

Anyone diagnosed mastocytosis? How?

Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read more

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