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It varies: Mastocytosis in the skin (called urticaria pigmentosa) are reddish-brown "freckles" on the skin that will hive (think of an itchy, red mosquito bite) when scratched or irritated. Mastocytosis throughout the body can present with flushing of the skin, mental "fogginess, " recurrent (often explosive) diarrhea, or even recurrent episodes of anaphylaxis. See a specialist for more information. ...Read more
Mastocytosis is a condition in which the body produces too many mast cells. These overgrown mast cells can be confined to the skin (cutaneous mastocytosis), or can be located in the bone marrow and throughout the body (systemic mastocytosis). Symptoms of these disorders vary by location and type, but are thought to be caused by the release of chemical mediators like histamine ...Read more
22yr female. Experience the following symptoms: angioedema, chronic urticaria, anaphylaxis, bone/muscle pain etc, is this systemic mastocytosis?
Serum tryptase level: You're certainly describing an entity that sounds histamine mediated but of course can be due to other causes and mediators. Does she have urticaria pigmentosa? Have you done a serum tryptase level? To my knowledge the one definitive diagnostic is a bone marrow bx. The other lab i look at to asses a histamine mediated process is anti high affinityfc epsilon receptor antibodies. Any meds? ...Read moreSee 1 more doctor answer
No.: Flushing is the sudden occurrence of redness and heat on the face and upper trunk. When due to mastocytosis it is often accompanied by palpitations, low blood pressure, dizziness, chest pain, explosive diarrhea, nausea, or fatigue. Other things, such as rosacea, medicines, and food additives, can also start a flushing attack. ...Read more
Biopsy is best: Cutaneous mastocytosis is confined to the skin and may present with brownish spots that itch or hive when scratched. It can be confirmed by a biopsy of the lesion. Systemic masto involves the bone marrow and presents with whole-body symptoms like flushing or anaphylaxis. High tryptase in the blood can be a clue, but it must be diagnosed by bone marrow biopsy. See a specialist in masto for info. ...Read moreSee 1 more doctor answer
Usually: Most cases of cutaneous (just in the skin) mastocytosis start in childhood and will go away as a person gets older. Sometimes the spots may stay but the reactions from them (itching or hives when the spots are irritated) fade over time. Systemic mastocytosis (throughout the body and bone marrow) is much rarer, but usually will not go away. See as specialist in mastocytosis for more information. ...Read moreSee 1 more doctor answer
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