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Doctor insights on: Mast Cell Colitis

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Are there any cures for mast cell disease?

Are there any cures for mast cell disease?

Usually not: In rare cases where it is due to a leukemia or related illness, curing or managing this works well, and some folks respond to gleevec (imatinib). Otherwise, we're left managing the symptoms, which is usually possible. I have a colleague with mastocytosis under quite good control, and there are support groups in communities and online. Good luck, and stay proactive. ...Read more

Mast Cell (Definition)

Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in ...Read more


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Can toothache trigger mast cell activation?

Can toothache trigger mast cell activation?

Allergic reaction: Mast cells are activated during allergic reactions and in some autoimmune diseases. A toothache is an infection and not an allergic reaction so here would be few mast cells. ...Read more

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Are mast cell tumors people tumors or dog tumors?

Are mast cell tumors people tumors or dog tumors?

I know humans: I don't know about dogs, but humans can get systemic mastocytosis. An uncommon clonal growth of mast cells. Mast cells may also be reactive, such as from allergies. ...Read more

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My husband was diagnosed with mast cell disease. Can anyone help?

My husband was diagnosed with mast cell disease. Can anyone help?

Need to see a doctor: Your husband need to follow-up with the doctor who made that diagnose. ...Read more

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Is it possible to have mast cell activation syndrome with normal tryptase levels? If so, how can the dr be sure you really have it

No and yes: Articles have suggested that tryptase levels correlate with disease activity. If the disease is not active, the levels are usually normal. ...Read more

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What is nonclonal mast cell activation disorder?

What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and I would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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What is the definition or description of: mast cell?

Mast cell: Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in mast cell activation disorders ...Read more

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What can you tell me about the diagnosis of Mast Cell Activation Syndrome?

MCAS: Mast Cell Activation Syndrome is a condition with signs ans symptoms involving the skin, gastrointestinal,cardiovascular, respiratory,and neurologic systems. It can be classified into primary, secondary and idiopathic. Show episodic symptoms consistent with mast cell mediator release affecting two or more organ systems with urticaria, angioedema,flushing,nausea, vomiting,diarrhea, abdominal cramping' ...Read more

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How can you be checked for a mast cell disorder or disease. Like mastcytosis or mcad? Is there a certain test that can verify or rule it out?

Biopsy: Biopsy looking for increased mast cells is the best way. One will also measure tryptase levels and other mediators in the blood. The organ to be biopsied depends on the spectrum of disease. There are some physical signs as well. Would see an allergist or a gastroenterologist who has some knowledge of this disease process. If localized to the skin a dermatologist might be of help. Bone marrow? ...Read more

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What does mast cell degranulation mean?

What does mast cell degranulation mean?

Good question,: I'm definitely guilty of recklessly using this term. The mast cell sits in your tissue near blood cells. On its surface are bound IgE ("allergy antibody") among other receptors. When the IgE binds to its antigen, the cell knows to "degranulate". Tiny pouches sitting within the cell move outward to the surface and fuse with the outer cell membrane. Contents, such as histamine, spill out. ...Read more

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What does "mast cell degranulation" mean?

What does "mast cell degranulation" mean?

Good question,: I'm definitely guilty of recklessly using this term. The mast cell sits in your tissue near blood cells. On its surface are bound IgE ("allergy antibody") among other receptors. When the IgE binds to its antigen, the cell knows to "degranulate". Tiny pouches sitting within the cell move outward to the surface and fuse with the outer cell membrane. Contents, such as histamine, spill out. ...Read more

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How is mast cell dysfunction different from an allergy?

How is mast cell dysfunction different from an allergy?

Mast Cells: Mast cells are an important part of the immune system. They are involved in allergies, anaphylaxis, wound healing and defense. In allergies, they are functioning normally, but excessively. Dysfunction implies they are not acting normally. ...Read more

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What does a mast cell activation disorder rash look like?

What does a mast cell activation disorder rash look like?

Rash: It can vary from hives to different types of rashes that can easily be diagnosed with a biopsy. ...Read more

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What is mast cell disease and how does it manifest in infants?

What is mast cell disease and how does it manifest in infants?

Brownish lesions on: Mastocytosis is when you have collections of mast cells, usually on the skin. These are brown spots, (1 or many) if you scratch them they turn red and swollen for a while (they form a wheal as histamine is released) Usually harmless, but a systemic form exists, not very common, with lesions in bone and other organs. ...Read more

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What is the difference between mast cell activation syndrome and mastocytosis?

Yes they Differ.: These are two separate conditions. Symptoms may be similar but the cause is different. In mastocytosis, patients have too many mast cells(MC). Because they are so plentiful, when one activates the other MC close by, will also release their chemicals (Histamine, Leukotrienes, prostaglandins, etc). MCAS is a condition that the numbers of MC are normal but overactive. Degranulating spontaneously. ...Read more

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I have just been diagnosed with systemic mast cell disease. Where can I learn about it?

I have just been diagnosed with systemic mast cell disease. Where can I learn about it?

Which type?: You have my sympathy. There are at least five different important types. Your first step will be to find out which variant you have, and of course get specialist treatment. There are several ongoing studies in which you may have the opportunity to participate -- this would be to your advantage. Good luck. ...Read more

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Can you have MCAS (Mast Cell Activation Syndrome) without an elevated tryptase level, even while symptomatic?

No: If you have symptoms and the tryptase is normal, it is highly unlikely to be from MCAS. However, anaphylaxis to food is not always associated with elevated tryptase level. It would be helpful if you can provide us with a description on the types of symptoms you have been experiencing during the attack. ...Read more

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Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Mastocytosis has specific diagnostic criterion.  Does mast cell activation syndrome have specific criterion?  If so, what is the criterion?

Complex: First you must have an elevated baseline tryptase level along with symptoms. Then you will need a bone marrow biopsy to determine what type of mast cell disorders you may have since they all behave the same way. ...Read more

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Was taking provigil but can't take anymore because I have mast cell and it releases histamine. What could take that don't release histamine?

Was taking provigil but can't take anymore because I have mast cell and it releases histamine.  What could take that don't release histamine?

Mastocytosis is ...: Mastocytosis is a complex disease and you are correct that Provigil and Nuvigil should not be used once mastocytosis is lab confirmed. Please consider a visit with a heme/oncology md as mastocytosis has different variations and morbities. With your multitude of medical issues, it might be worthy to seek care at a tertiary medical center for collaborative care. Best wishes. ...Read more

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What is the difference between an abscess and a mast cell tumor?

What is the difference between an abscess and a mast cell tumor?

Quite different: Mast cell tumors are rare malignancies that originate in the skin. Abscesses are common, basically pus pockets due to infection. Abscesses are treated by incision and drainage, sometimes along with antibiotics. Mast cell tumors are surgically removed. Chemotherapy may be used if the tumor recurs. ...Read more

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What is the difference between an abscess and a mast cell tumor?

One is a neoplasm: An abscess is a cavity that contains pus. It indicates a soft tissue infections that got encapsulated (contained) and now it is a sphere that has pus (bacteria and dead cells, ...)

Mast cell tumor is a rare tumor (neoplasm) generally malignant that originates in mast cells . Mast cell tumors are more common in Dogs in the skin, than in humans. Mast cells release histamine ...Read more

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Is there any relationship between a pterygium and mast cell activation syndrome?

No: A pterygium is a triangular wedge of fibrovascular tissue of the conjunctiva that encroaches on the cornea. It has nothing to do with mast cell activation or anaphylaxis. Pterygium is a proliferative disorder whose pathogenesis and cause has not been fully elucidated; but exposure to ultraviolet light is believed to play a role in its formation. ...Read more

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Does desloratadine have a mast-cell stabilising effect which can cure an allergy?

Does desloratadine have a mast-cell stabilising effect which can cure an allergy?

Desloratadine: Is an antihistamine that blocks a histamine receptor but does not stabilize the mast cells, there is no medication that can cure allergies, your best potential for cure will be from allergen immunotherapy. If you have an allergist around, ask them aout it. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

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What are the tests for diagnosing Mast Cell Activation Syndrome? And what kind of doctor do I need to go to?

Multiple..: There are multiple tests that range from blood tests to tissue biopsy, however great part of the diagnosis relies on symptoms which are allergic type, systemic and gastrointestinal symptoms. You would need to see an Allergist/Immunologist for evaluation and treatment. ...Read more

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Is chronic urticaria a mast cell disease?

Is chronic urticaria a mast cell disease?

Yes.: Mast cells are the source of histamine and other biologically active mediators that trigger hives. ...Read more

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What's chronic urticaria vs mast cell disease?

What's chronic urticaria vs mast cell disease?

Complex problems: There are at least five important systemic mast cell diseases (mastocytosis) and even more causes of chronic urticaria (of which some mastocytosis diseases are only one cause). Often, no cause is ever found for chronic urticaria. A hematologist will probably treat mast cell disease -- perhaps in a research study -- while a dermatologist will manage chronic urticaria. Good luck; stay proactive. ...Read more

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What does "mast cell degranulation" mean in an allergic reaction?

Mast cell: Definition protein involved in mast cell degranulation. Mast cell is a large, ovoid cell of hematopoietic lineage, with a centrally located nucleus and numerous large, intensely basophilic granules. The binding of an antigen to its specific immunoglobulin-e antibody on the mast cell surface triggers the release of the mc granules. Mast cells are involved in hypersensitivity reactions. ...Read more

Dr. Eric Kaplan
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Colitis (Definition)

Inflammation or infection of ...Read more