Doctor insights on:
Mast Cell Activation
Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in ...Read more
MCAS: Mast Cell Activation Syndrome is a condition with signs ans symptoms involving the skin,gastrointestinal,cardiovascular,respiratory,and neurologic systems. It can be classified into primary,secondary and idiopathic . show episodic symptoms consistent with mast cell mediator release affecting two or more organ systems with urticaria,angioedema,flushing ,nausea,vomiting,diarrhea, abdominal cramping' ...Read moreSee 1 more doctor answer
Yes they Differ.: These are two separate conditions. Symptoms may be similar but the cause is different. In mastocytosis, patients have too many mast cells(MC). Because they are so plentiful, when one activates the other MC close by, will also release their chemicals (Histamine, Leukotrienes, prostaglandins, etc). MCAS is a condition that the numbers of MC are normal but overactive. Degranulating spontaneously. ...Read moreSee 1 more doctor answer
Possibly, but: Possibly with the former, but not with the latter. ...Read more
Can you have MCAS (Mast Cell Activation Syndrome) without an elevated tryptase level, even while symptomatic?
No: If you have symptoms and the tryptase is normal, it is highly unlikely to be from MCAS. However anaphylaxis to food is not always associated with elevated tryptase level. It would be helpful if you can provide us with a description on the types of symptoms you have been experiencing during the attack. ...Read more
Can multiple foods intolerance developed within months in a teen girl with celiac be a sign of mast cell activation disorder?
Wouldn't assume so: There are many things that gluten reactivity predisposed someone to that interfere with digestion. The primary gut injury & episodic unknown exposures often lead to cross reactivity/intolerance to non gluten foods.Things like chocolate,cow milk,egg or corn can trigger immune related responses.Food dyes like #40 red & others can also trigger symptoms.Detailed testing can identify many.(Cyrex labs) ...Read more
No: A pterygium is a triangular wedge of fibrovascular tissue of the conjunctiva that encroaches on the cornea. It has nothing to do with mast cell activation or anaphylaxis. Pterygium is a proliferative disorder whose pathogenesis and cause has not been fully elucidated; but exposure to ultraviolet light is believed to play a role in its formation. ...Read moreSee 1 more doctor answer
What are the tests for diagnosing Mast Cell Activation Syndrome? And what kind of doctor do I need to go to?
Multiple..: There are multiple tests that range from blood tests to tissue biopsy, however great part of the diagnosis relies on symptoms which are allergic type, systemic and gastrointestinal symptoms. You would need to see an Allergist/Immunologist for evaluation and treatment. ...Read moreSee 1 more doctor answer
Can I have mild symptoms and still have MAST cell activation syndrome and only a few triggers. Only some foods, smells, creams, alcohol cause reactons?
Absolutely: my wife suffers with MAST Cell after contracting Lyme & Co-Infections. Triggers can change so keeping a diary is helpful, to see what other factors (environmental, mold, toxins) correlate with your triggers. The diagram to the right, gives some good info. Triggers can also change depending on viral load and status of immune function. Low Histamine Diet helps. Good luck on this journey! ...Read more
Could mast cell activation disorder cause a virus to trigger severe sinus symptoms and reactive airways?
Mast cell disorders: A variety of “triggers” may induce a mast cell response. These include drug abuse, alcohol drinking, preservatives, stress, sunlight, environmental toxins, bacteria/fungi/mold, artificial colors or flavorings, heat/cold, and presumably viral infection. Minimizing your exposure to these triggers may help redcuce your risk of triggering mast cell activation. ...Read more
Could multiple contact allergies diagnosis through patch test (chronic itching ) trigger a mast cell activation?
No: Contact allergy causes allergic contact dermatitis, which is a red, itchy, patchy skin rash that develops on contact with the substances you are allergic to. It is a delayed hypersensitivity reaction caused by t lymphocyte, not mast cell. Mast cell activation syndrome is a separate disease. ...Read moreSee 1 more doctor answer
Is there any known/suspected relationship between. Undifferentiated connective tissue disease and mast cell activation syndrome ?
Unaware: I am not aware of such a connection ...Read more
I am on 20mg rabeprazole and have been prescription 400mg x2 daily cimetidine for mast cell activation disorder - are they safe to take together?
Is there any known/suspected relationship between. Undifferentiated connective tissue disease and mast cell activation syndrome ? How is uctd dx?
UCTD: Good question. Not sure. Sorry can't answer that one comfortably. ...Read more