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Doctor insights on: Mast Cell Activation

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What is nonclonal mast cell activation disorder?

What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and I would much rather have this than one of the clonal forms. Http://www. Ncbi. Nlm. Nih. Gov/pubmed/23212667. ...Read more

Mast Cell (Definition)

Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in ...Read more


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What can you tell me about the diagnosis of Mast Cell Activation Syndrome?

What can you tell me about the diagnosis of Mast Cell Activation Syndrome?

MCAS: Mast Cell Activation Syndrome is a condition with signs ans symptoms involving the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems. It can be classified into primary, secondary and idiopathic. Show episodic symptoms consistent with mast cell mediator release affecting two or more organ systems with urticaria, angioedema, flushing, nausea, vomiting, diarrhea, abdominal cramping' ...Read more

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Can toothache trigger mast cell activation?

Can toothache trigger mast cell activation?

Allergic reaction: Mast cells are activated during allergic reactions and in some autoimmune diseases. A toothache is a infection and not an allergic reaction so here would be few mast cells. ...Read more

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Is it possible to have mast cell activation syndrome with normal tryptase levels? If so, how can the dr be sure you really have it

No and yes: Articles have suggested that tryptase levels correlate with disease activity. If the disease is not active, the levels are usually normal. ...Read more

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What does a mast cell activation disorder rash look like?

What does a mast cell activation disorder rash look like?

Rash: It can vary from hives to different types of rashes that can easily be diagnosed with a biopsy. ...Read more

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What is the difference between mast cell activation syndrome and mastocytosis?

Yes they Differ.: These are two separate conditions. Symptoms may be similar but the cause is different. In mastocytosis, patients have too many mast cells (MC). Because they are so plentiful, when one activates the other MC close by, will also release their chemicals (Histamine, Leukotrienes, prostaglandins, etc). MCAS is a condition that the numbers of MC are normal but overactive. Degranulating spontaneously. ...Read more

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Can you have MCAS (Mast Cell Activation Syndrome) without an elevated tryptase level, even while symptomatic?

No: If you have symptoms and the tryptase is normal, it is highly unlikely to be from MCAS. However anaphylaxis to food is not always associated with elevated tryptase level. It would be helpful if you can provide us with a description on the types of symptoms you have been experiencing during the attack. ...Read more

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Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Mastocytosis has specific diagnostic criterion. Does mast cell activation syndrome have specific criterion? If so, what is the criterion?

Complex: First you must have an elevated baseline tryptase level along with symptoms. Then you will need a bone marrow biopsy to determine what type of mast cell disorders you may have since they all behave the same way. ...Read more

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Is there any relationship between a pterygium and mast cell activation syndrome?

No: A pterygium is a triangular wedge of fibrovascular tissue of the conjunctiva that encroaches on the cornea. It has nothing to do with mast cell activation or anaphylaxis. Pterygium is a proliferative disorder whose pathogenesis and cause has not been fully elucidated; but exposure to ultraviolet light is believed to play a role in its formation. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

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What are the tests for diagnosing Mast Cell Activation Syndrome? And what kind of doctor do I need to go to?

Multiple..: There are multiple tests that range from blood tests to tissue biopsy, however great part of the diagnosis relies on symptoms which are allergic type, systemic and gastrointestinal symptoms. You would need to see an Allergist/Immunologist for evaluation and treatment. ...Read more

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Could mast cell activation disorder cause a virus to trigger severe sinus symptoms and reactive airways?

Could mast cell activation disorder cause a virus to trigger severe sinus symptoms and reactive airways?

Mast cell disorders: A variety of “triggers” may induce a mast cell response. These include drug abuse, alcohol drinking, preservatives, stress, sunlight, environmental toxins, bacteria/fungi/mold, artificial colors or flavorings, heat/cold, and presumably viral infection. Minimizing your exposure to these triggers may help redcuce your risk of triggering mast cell activation. ...Read more

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Could multiple contact allergies diagnosis through patch test (chronic itching) trigger a mast cell activation?

Could multiple contact allergies diagnosis through patch test (chronic itching) trigger a mast cell activation?

No: Contact allergy causes allergic contact dermatitis, which is a red, itchy, patchy skin rash that develops on contact with the substances you are allergic to. It is a delayed hypersensitivity reaction caused by t lymphocyte, not mast cell. Mast cell activation syndrome is a separate disease. ...Read more

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Can multiple foods intolerance developed within months in a teen girl with celiac be a sign of mast cell activation disorder?

Can multiple foods intolerance developed within months in a teen girl with celiac be a sign of mast cell activation disorder?

Wouldn't assume so: There are many things that gluten reactivity predisposed someone to that interfere with digestion. The primary gut injury & episodic unknown exposures often lead to cross reactivity/intolerance to non gluten foods. Things like chocolate, cow milk, egg or corn can trigger immune related responses. Food dyes like #40 red & others can also trigger symptoms. Detailed testing can identify many. (Cyrex labs) ...Read more

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I am on 20mg rabeprazole and have been prescription 400mg x2 daily cimetidine for mast cell activation disorder - are they safe to take together?

I am on 20mg rabeprazole and have been prescription 400mg x2 daily cimetidine for mast cell activation disorder - are they safe to take together?

Yes, but...: ...You may be able to maximize your dose of Cimetidine alone so that rabeprazole can be discontinued. Talk this over with your prescribing physician, ; clarify with him/her the duration of treatment that's planned. ...Read more

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Is Zantac (ranitidine) and cetirizine safe to take long term. I have mast cell activation disorder so use these for symptom relief and prevention?

Yes: Mast cell activation disorder can be a difficult disorder to treat. Thankfully, both Cetirizine and zantac (ranitidine) have very favorable side effect profiles so they can be used long term with minimal risk. ...Read more

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I have mast cell activation disorder (idiopathic) and am going crazy with skin crawling. I have been on Ketotifan twice daily as well as reactine twice daily. Any advice on further measures? I was considering Benadryl during this awful episode. I tried X

I have mast cell activation disorder (idiopathic) and am going crazy with skin crawling. I have been on Ketotifan twice daily as well as reactine twice daily. Any advice on further measures? I was considering Benadryl during this awful episode. I tried X

MCAD: You can try Benadryl, (diphenhydramine) but don't overdose, mind you, you are on Reactine (cetirizine) which might cause sedation as well, it isn't totally non sedating, just less sedating. Other drugs as H2 blockers like ranitidine can help too, as well prescription anti-leukotreines like montelukast or zafirlukast can be of help. You need to follow up closely with your Allergist/Immunologist, good luck ...Read more

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Natural alternative for Diamox or topamax? I've dysautonomia (hyperPOTS) and mast cell activation disorder with connective tissues disorder. I'm allergic to gluten which is part of diamox. I have an intracranial pressure and breathing difficulty, when lay

Natural alternative for Diamox or topamax? I've dysautonomia (hyperPOTS) and mast cell activation disorder with connective tissues disorder. I'm allergic to gluten which is part of diamox. I have an intracranial pressure and breathing difficulty, when lay

Comprehensive exam: This question requires either allergic medical or rheumatology comprehensive evaluation and examination. If you in fact, have increased intracranial pressure: please go directly to your local ER. I have seen you post on POTS submitted multiple times and answered by many physicians. Please get examined or hospitalized to resolve your medical issues. ...Read more

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What is the definition or description of: mast cell?

Mast cell: Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in mast cell activation disorders ...Read more

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How can you be checked for a mast cell disorder or disease. Like mastcytosis or mcad? Is there a certain test that can verify or rule it out?

Biopsy: Biopsy looking for increased mast cells is the best way. One will also measure tryptase levels and other mediators in the blood. The organ to be biopsied depends on the spectrum of disease. There are some physical signs as well. Would see an allergist or a gastroenterologist who has some knowledge of this disease process. If localized to the skin a dermatologist might be of help. Bone marrow? ...Read more

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Are there any cures for mast cell disease?

Usually not: In rare cases where it is due to a leukemia or related illness, curing or managing this works well, and some folks respond to gleevec (imatinib). Otherwise, we're left managing the symptoms, which is usually possible. I have a colleague with mastocytosis under quite good control, and there are support groups in communities and online. Good luck, and stay proactive. ...Read more

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Are mast cell tumors people tumors or dog tumors?

Are mast cell tumors people tumors or dog tumors?

I know humans: I don't know about dogs, but humans can get systemic mastocytosis. An uncommon clonal growth of mast cells. Mast cells may also be reactive, such as from allergies. ...Read more

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My husband was diagnosed with mast cell disease. Can anyone help?

My husband was diagnosed with mast cell disease. Can anyone help?

Need to see a doctor: Your husband need to follow-up with the doctor who made that diagnose. ...Read more

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What does mast cell degranulation mean?

What does mast cell degranulation mean?

Good question,: I'm definitely guilty of recklessly using this term. The mast cell sits in your tissue near blood cells. On its surface are bound IgE ("allergy antibody") among other receptors. When the IgE binds to its antigen, the cell knows to "degranulate". Tiny pouches sitting within the cell move outward to the surface and fuse with the outer cell membrane. Contents, such as histamine, spill out. ...Read more

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What does "mast cell degranulation" mean?

What does "mast cell degranulation" mean?

Good question,: I'm definitely guilty of recklessly using this term. The mast cell sits in your tissue near blood cells. On its surface are bound IgE ("allergy antibody") among other receptors. When the IgE binds to its antigen, the cell knows to "degranulate". Tiny pouches sitting within the cell move outward to the surface and fuse with the outer cell membrane. Contents, such as histamine, spill out. ...Read more

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How is mast cell dysfunction different than an allergy?

How is mast cell dysfunction different than an allergy?

Mast Cells: Mast cells are an important part of the immune system. They are involved in allergies, anaphylaxis, wound healing and defense. In allergies, they are functioning normally, but excessively. Dysfunction implies they are not acting normally. ...Read more

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