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Doctor insights on: Marfan Affect My Children

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What are the chances for a man with Marfan syndrome to pass it on to his children?

What are the chances for a man with Marfan syndrome to pass it on to his children?

50% for each child: Marfan syndrome is caused by a mutation of the fbn1 gene on chromosome 15. An affected man (or woman) has one normal and one mutant fbn1 gene in each of his (or her) cells. For each of his children, the chance that he will pass on the mutation is 1/2 or 50%. This pattern of inheritance is called autosomal dominant. ...Read more

Dr. Scott McLean
289 doctors shared insights

Marfan Syndrome (Definition)

Marfan's syndrome is a genetic disorder caused by defects in a protein called fibrillin that, along with collagen, provides most of the structural support of our tissues. Individuals with Marfan's are often tall, lanky, have long arm spans, and are hyperflexible. The most serious complication of Marfan's is caused by defects in the wall of the aorta, the large blood vessel that leaves the heart and supplies the ...Read more


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Does Marfan syndrome only affect males?/does Marfan syndrome only affect females?

Does Marfan syndrome only affect males?/does Marfan syndrome only affect females?

Affects men & women: Marfan syndrome is autosomal dominant, not sex-linked. About one in 3000-5000 people have marfan syndrome. It affects an equal number of males and females. ...Read more

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I think I have Marfan syndrome, but i'm not sure if I want to go get checked. Will it affect insurance?

I think I have Marfan syndrome, but i'm not sure if I want to go get checked. Will it affect insurance?

Unknown: The new health care law says that insurers cannot deny insurance for "preexisting conditions". So if this health care law stays in place it will not be a problem. No matter what, if you may have marfan's you need to have it confirmed, and if positive see a cardiologist. With good care, pts with marfan's can have normal lifespan. Without care they can have cardiac problems. ...Read more

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How will having Marfan syndrome affect my long-term health?

Cardiovascular: Heart & blood vessel problems are most likely to impact your health. Also detached retina, collapsed lung, learning disabilities. See pubmed article on marfan's : www.Ncbi.Nih.Gov/pubmedhealth/pmh1455/#adam_000418.Disease.Signs. Or www.Marfan.Org. ...Read more

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What is marfan's syndrome? What causes it and how does it affect body tissues?

What is marfan's syndrome? What causes it and how does it affect body tissues?

Marfan syndrome: is a genetic disorder of the connective tissue. Marfan syndrome most often affects the connective tissue of the heart, blood vessels, eyes and bones. The treatment is individualized to the patient's needs. ...Read more

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How does Marfan syndrome affect the heart?

How does Marfan syndrome affect the heart?

Enlarges aortic root: Patients with marfan syndrome have tendency to develop aortic wall enlargemnt causing mainly aortic root aneurysms.This can lead to aortic valve insufficency and also aortic dissection which is a tear in the wall of the aorta. ...Read more

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What do you need to know if you had Marfan's syndome as well as hiv, how could this affect me!6?

What do you need to know if you had Marfan's syndome as well as hiv, how could this affect me!6?

Unrelated: The two are completely unrelated, you should consider them separately, and not worry about how one condition will affect the other. ...Read more

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How does Marfan syndrome affect your eyes?

Lens dislocation: The most common problem is that the lenses in the eyes are held in place by zonules. These are weakened by this syndrome and frequently the lenses can be come partially/totally dislocated causing blurred vision or other problems within the eyes. See an ophthalmologist. ...Read more

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Does Marfan syndrome affect the brain?

No: Marfan syndrome affects the eyes and damages one's vision, and the syndrome affects the lining of the spinal cord, but it typically does not cause brain problems. ...Read more

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Can you tell me the features of the disorder Marfan syndrome?

Marfan's syndrome: It is a broad topic. Difficult to cover here. Please refer to the site: http://en.Wikipedia.Org/wiki/marfan_syndrome. ...Read more