Doctor insights on:
Mantle Cell Lymphoma Life Expectancy
Mantle cell: Lymphoma has a broad range of expected survival. The minority of patients have an indolent course, and may not even require therapy at the time of diagnosis. More commonly treatment is initiated with moderate to aggressive chemotherapy with duration of benefit on the order of 3-5 years. With recurrence the management can be more challenging. ...Read more
Stage?: Depends on stage. There are two subsets of mantle cell nhl. One is an indolent subset in which 5 yr survival approaches 70-80%. The othe more aggressive subset has a prognosis of only 50/50 at three years. But stage also matters. ...Read more
Yes: Controlis quite high, but it needs aggressive treatment. ...Read more
Non hodgkin's: Mantle cell lymphoma is a subset of non hodgkin's lymphoma. Under microscope, it looks like clusters of small size of lymphoid cells mimicking appearance of indolent/slow-progressing lymphoma, however it behaves like an agressive lymphoma. The treatment would be combinations of chemotherapies plus biological therapy. ...Read more
Mantle cell lymphoma: Is a less common b-cell disease in the non-hodgkin's lymphoma group. It tends to be advanced stage when diagnosed, and can have a propensity to involve both the gut and skin. About 20% of cases behave indolently, and treatment is quite effective at diagnosis. Late relapses are common, and treatment is more challenging the second time around. ...Read more
It depends: Most lymphomas grow quite fast. That is often the case with mantle cell lymphoma too. So I would say it takes 3-6 months before the symptoms become pretty severe that we/you can not miss it easily. ...Read more
Months, anywhere: Mantle cell lymphoma is a rare subtype of non-hodgkin's lymphoma. It usually grows relatively slowly and might take several weeks to a few months to develop. It most commonly presents in the lymph nodes, the blood, and the spleen although it can also present anywhere in the G.I. Tract from the stomach down to the colon. ...Read more
Go to ER now!!: BP of 70/40 is very abnormal. You should check whether the machine is accurate-make sure the cuff placement is correct. If it is confirmed, you absolutely should bring your mother to er now. She may be severely dehydrated or other condition that perhaps related or unrelated to her mantle cell lymphoma. Bring her to er now. ...Read more
What type of nodes would appear with mantle cell lymphoma or any other type of malignancy? Would they be rigid and fixed or can they be soft and moveable? Internist felt node but said likely benign.
Lymph node: Generally malignant lymph nodes are firm, but I have seen some that were soft and movable. If this node doesn't recede within a week or so, and if new enlarged nodes appear a biopsy would seem advisable. Discuss this with your physician and he/she will advise you about what type of follow-up is best. ...Read more
Serious: Mantle cell lymphoma is a serious type of non-hodgkin lymphoma. In a younger patient under the age of 70 and otherwise in good health it can be put into remission for several years with chemotherapy and stem cell transplantation. In older patients or patients who are otherwise sick there are some treatments I can put the disease into remission for a few years. ...Read more
Mantle Cell Lymphoma: ...is a type of non Hodgkin's lymphoma characterized by the genetic rearrangement of two chromosomes. This causes an abnormal fusion of two genes: Immunoglobulin (IgH) and Cyclin D1. Molecular studies that can detect this abnormality includes either FISH or RT-PCR. Flow cytometry is also good at identifying abnormal cells based on cell surface antigen expression. ...Read more
My mother just passed away from mantle cell lymphoma, what might have caused her to act so strange at the end?
Many causes: My condolences on your loss. There are many reasons for confusion and delirium at the end of life. Mantle cell lymphoma specifically can sometimes go to the brain of a patient although this is quite rare. It is much more likely that either her discomfort or the medications that she was on to keep her comfortable made her somewhat confused. ...Read more
Any known treatments for late onset neutropenia due to rituximab. The R was being used for mantle cell lymphoma maintenance. Thanks.
May not be needed: This doesn't always require treatment. If you have an active severe infection or neutropenia is severe then it can be treated with neupogen. If you don't have an infection or very severe problem it is best left alone. Try to be careful about staying away from other people who are sick and wash your hands frequently. ...Read more
Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or rituximab+bendamustine?
There is no: Definitive answer to your question. Studies have compared the strategies you mention. The high dose ara-c arm was closed because it was difficult to mobilize stem cells for transplant after these regimens. Bendamustine-r is a good program, and many centers would consolidate a good response with an autograft. ...Read more
My grandpa just got dx with mantle cell lymphoma by biopsy 82y/o. bone marrow biopsy & pet scan not back. Prognosis & treatment? Is it genetic?
?????: The better question would be: why in God's creation would someone not get treated for a highly curable disease like Hodkin's disease? I am not even sure that an accurate answer to your question is possible to come up with. Ultimately it would cause death but how long it would take? Cannot tell. ...Read more
Depends: There are many factors that effect life expectancy including the patients underlying health and the stage of lymphoma. For example lymphoma that is slower growing and has not spread is a better case than a lymphoma that is aggressive and has spread to multiple organs. Hard to answer that question without more information. ...Read more
Not necessarily.: "lymphoma" acrtually encompasses many different diagnoses. In general, lymphomas a very responsive to chemotherapy. Some, like hodgkin lymphoma are frequently curable, even in advanced stage. For some of the aggressive lymphomas, response depends on a number of factors, including age and stage, but still can do well. The low grade lymphomas are not curable, but many years of life are possible. ...Read more
Prognosis is Good.: Follicular lymphoma is a slow growing type of nhl which responds very well to treatment, but can rarely be cured. Despite this, the prognosis is generally very good and the median survival is about 8-15 years according to the nci. A recently published study from stanford has shown that since 1997 the median survival has increased to over 18 years. Life expectancy depends on the extent of disease. ...Read more
I am 31 and have had follicular lymphoma for 5 years. I am in remission. I have cvid. For my age what is the life expectancy?
Complex: CVID is a complex disease, nowadays regaining good humoral (antibody) immunity with proper replacement therapy and prompt treatment with antibiotics has improved the quality of life tremendously for patients with CVID, although lymphoma is a complication of the disease, but you survived 5 years already, which is the benchmark year for good prognosis for lymphoma, longevity can be as non-CVID ...Read more
Depends: Hodgkin lymphoma is a highly curable cancer. Severe CHF might limit some of the chemotherapy options, but even in the unusual circumstance that no chemotherapy could be given, cures can still be achieved with radiotherapy alone. Life expectancy for untreated disease depends on a number of factors but is likely to be only about 12 months on average with some doing better and some worse. ...Read more
What is life expectancy for stage 4 non-hodgkin's lymphoma that has spread to spine, liver & spleen?
Depends.: Life expectancy after diagnosis is dependent upon stage of disease among other things. The earlier the stage the better the prognosis and the longer we expect someone to remain in remission and the longer we expect them to survive. ...Read more
Depends: Treatment depends on site (usually gastric) and whether there is an associated infection as underlying cause (H. Pylori in gastric). Treating infection can resolve lymphoma in some cases. Other isolated maltomas might be treated with radiation and resolve. Chemo is last choice. Prognosis can be very good. Talk to your oncologist. ...Read more
It depends on the St: Small cell lung cancer can be localized to chest (called Limited disease) or it can be spread outside of the chest and involve other organs like liver/ Bone etc when it is called Extensive disease. So you need to tell us if your lung cancer is Limited disease or Extensive Disease? Then we can give you the relevant information about prognosis. ...Read more
Hard to know: It depends on where the cancer came from. Most cancerous nodes in this area would be from lip cancer, floor of the mouth cancer, cancer of the gum. With proper treatment, which can include surgery, radiation, and possible chemotherpy, the prognosis can be good. Other health problems such as smoking, diabetes, heart and lung disease all decrease the prognosis. ...Read more
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