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Doctor insights on: Mannose Binding Lectin

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Is there any treatment to reverse mannose binding lectin deficiency?

Is there any treatment to reverse mannose binding lectin deficiency?

Experimental: But intravenous infusion of purified mannose-binding lectin from a donor plasma is being used. ...Read more

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What can a very low level of mannan/mannose binding lectin mean?

What can a very low level of mannan/mannose binding lectin mean?

Could: Be seen with immune deficiency, or it could be hereditary. May predispose person to certain infections. ...Read more

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If vaccinations don't raise a mannose binding lectin deficiency, what is the next step?

If vaccinations don't raise a mannose binding lectin deficiency, what is the next step?

Mannose binding: This genetic immune deficiency disorder makes people prone to recurrent infections such as uri, pneumonia and meningitis. Depending on the type of infection, the symptoms caused by the infections vary in frequency and severity. Unaware that vaccinations affect this in any way. ...Read more

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Probiotics gives lactobacillus acidophillus & bifidobacterium. Whey: beta lactoglobulin & alpha lactalbumin. Can both provide similar benefits?

Probiotics gives lactobacillus acidophillus & bifidobacterium. Whey: beta lactoglobulin & alpha lactalbumin. Can both provide similar benefits?

No: Probiotics and whey provide different benefits. They both have "lacto" in their names, which may be the source of your confusion. Lacto means related to milk. Lactobacillus is a bacteria that can grow in dairy products. Whey is the thin, clear liquid that is left when milk has curdled; it is high in protein. Probiotics are good for intestinal health. Whey is primarily a protein source. ...Read more

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Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?

Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?

Yes: Mannose-binding lectin deficiency is a complement disorder. Low igm and subclass igg (in your case 3 ; 4) is a separate entity. With low immunoglobulins and no response to vaccines, ivig would be reasonable. See an immunologist to evaluate this. ...Read more

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Plasma Vitamin D <4.2 ng/mL Serum Vitamin B12 -197 Serum TSH-2.805 Serun Alkaline Phosphatase-356 WBC-3300 MCV-103 MCH-34 Platelet-141k?

Plasma Vitamin D  <4.2 ng/mL
Serum Vitamin B12  -197
Serum TSH-2.805
Serun Alkaline Phosphatase-356
WBC-3300
MCV-103
MCH-34
Platelet-141k?

Need Vits D3 and B12: You are severely deficient in Vitamins D3 and B12. I recommend 10,000 IU of Vit D3 per day, and 1,000 mcg methylcobalamin each day. Your D3 levels should be 60-70 ng/dl. ...Read more

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Can taking bovine colostrum increase plasma immunoglobulin levels, thereby masking an underlying immunoglobulin deficiency by altering blood tests?

Can taking bovine colostrum increase plasma immunoglobulin levels, thereby masking an underlying immunoglobulin deficiency by altering blood tests?

Unlikely: Very thoughtful idea. Unfortunately, the bovine immunoglobins are too large to be absorbed from the intestine and would be digested by stomach and intestinal juices and enzymes. With use you would be providing body with raw materials for making your own immunoglobulins, but at a cost. Any "complete" proteins from eggs or milk could provide the same protein precursors and support good health. ...Read more

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Help me interpret &health implications iron binding (tibc). 455. High. Uibc 430. High. Iron serum. 25 low. Iron saturation 5 alert.

Help me interpret &health implications
iron binding  (tibc).  455. High. 
Uibc 430. High. 
Iron serum. 25   low.  
Iron saturation 5  alert.

TIBC: (tibc)iron deficiency will translate into a high total iron binding capacity( i.E: there is more space available for more iron to bind to), uibc is calculated by substracting level of iron from TIBC ( 455-25= 430), transferrin is used to transport iron, 5% saturation means only 5% of transferrin is used to bind iron, because there is not enough iron for it to bind to, (iron deficiency anemia). ...Read more

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Globulin level: 4.5, Albumin level: 3.9, Total Protein: 8.4, Albumin/Globulin Ratio: 0.9, AST: 68, ALT: 105. What do these levels mean?

Globulin level: 4.5, Albumin level: 3.9, Total Protein: 8.4, Albumin/Globulin Ratio: 0.9, AST: 68, ALT: 105. What do these levels mean?

Need med history: You need to tell us why was this test done. Did you have some complaints? Once we know your symtoms, if any, it is easier to interpret your lab results. Your liver enzymes are slightly high and so is the globulin level which can occur due to liver problems like Hepatitis. Your doctor needs to recheck these labs in another one or two months and find the cause?hepatitis? ...Read more

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Recent lab work shows the following: iron 57 dl, total iron binding capacity 363 dl, iron total binding capacity 16% and ferritin 184.2ml. Pls explain?

Recent lab work shows the following: iron 57 dl, total iron binding capacity 363 dl, iron total binding capacity 16% and ferritin 184.2ml. Pls explain?

Iron panel: Iron panel sometimes is confusing, your panel number is one of them. Let me ask you why your iron panel was checked? If your lab originally showed anemia and this are supplementary test to see what is the reason for your anemia, i would say that you have very mild iron deficiency. At your age anemia should be aggressively worked up to find the reason. Please follow with your doctor. ...Read more

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Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Increased aldolase,  complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin.   Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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I've iron deficiency.I take ferose-f (100 mg iron+ 350mcg folic acid) is drinking tea or coffer after taking this medicine nullifies its effect.

I've iron deficiency.I take ferose-f (100 mg iron+ 350mcg folic acid) is drinking tea or coffer after taking this medicine nullifies its effect.

Yes: Tea can decrease iron absorption. Milk, milk products and calcium containing products can also decrease iron absorption. Best to take iron one hour before or after a dairy product. ...Read more

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Serum iron 4umol/L Transferrin IBC 64umol/L Transferrin saturation 6% Serum ferritin assay 62ug/L Am I iron deficient? levels on 2 iron tablets /day

Serum iron 4umol/L
Transferrin IBC 64umol/L
Transferrin saturation 6%
Serum ferritin assay 62ug/L

Am I iron deficient? levels on 2 iron tablets /day

Need to evaluate: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your results are consistent with iron deficiency. Do you have heavy periods? Do you eat a normal diet? Have you been evaluated for celiac disease? If you are not able to absorb oral iron, it may be given intravenously. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine. ...Read more

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Does Effexor (venlafaxine) raise shbg (sex hormone binding gobulin) levels?

Does Effexor (venlafaxine) raise shbg (sex hormone binding gobulin) levels?

Interesting question: I have not found any publications specifically studying this question. Antipsychotics and Prozac (fluoxetine) can affect prolactin, potentially changing sex hormone levels. This may or may not relate to shbg levels, though. I did find one small (20 patients) study online concerning low testosterone levels and antidepressant-induced sexual dysfunction: http://tinyurl.Com/mk84cfr further research needed. ...Read more

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What can a very low level of mannose-binding lectin mean and how can it be treated?

What can a very low level of mannose-binding lectin mean and how can it be treated?

A rare: Deficiency to affect someone clinically, deficiencies are more common. These help the immune system do its job in clearing certain infections. Treatment is experimental at this moment. ...Read more

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What can a very low level of mannan/mannose binding lectin mean?

Could: Be seen with immune deficiency, or it could be hereditary. May predispose person to certain infections. ...Read more

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Is there any treatment to reverse mannose binding lectin deficiency?

Experimental: But intravenous infusion of purified mannose-binding lectin from a donor plasma is being used. ...Read more

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If vaccinations don't raise a mannose binding lectin deficiency, what is the next step?

Mannose binding: This genetic immune deficiency disorder makes people prone to recurrent infections such as uri, pneumonia and meningitis. Depending on the type of infection, the symptoms caused by the infections vary in frequency and severity. Unaware that vaccinations affect this in any way. ...Read more

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I have mannose binding lectin deficiency - does this mean I am 'immunocompromised'? Is it safe to be around animals at a zoo?

I have mannose binding lectin deficiency - does this mean I am 'immunocompromised'? Is it safe to be around animals at a zoo?

Wash your hand: MBLD is a disorder of the "Complement" pathway of the immune system, which helps protect against certain types of bacteria (encapsulated). People with MBLD may be more susceptible to other germs as well. Talk to your doc about Pneumococcal and Meningococcal vaccines. As for the zoo, Salmonella is a particular risk. But enjoy the zoo--just wash hands and don't touch animals or stool! ...Read more

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Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?

Yes: Mannose-binding lectin deficiency is a complement disorder. Low igm and subclass igg (in your case 3 ; 4) is a separate entity. With low immunoglobulins and no response to vaccines, ivig would be reasonable. See an immunologist to evaluate this. ...Read more

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Should vaccines i'm very low in (tetanus, hib, men c, pneuomococcle) be given when I have mannose-binding lectin deficiency, low igm, igg3 and igg4?

Should vaccines i'm very low in (tetanus, hib, men c, pneuomococcle) be given when I have mannose-binding lectin deficiency, low igm, igg3 and igg4?

Yes.: They may need to be given more than once if your immune response is compromised, but you're still safer with them than without. ...Read more

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Can increasing my intake of calcium help combat my low levels of mannose-binding protein?

Can increasing my intake of calcium help combat my low levels of mannose-binding protein?

MBL-2: Mannose-binding protein deficiency is a rare disease, which overall does not end up affecting the immunity is much as suspected it would. Increasing Calcium will not help in anyway. Hope that helps. ...Read more

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Can you tell me about d mannose?

Can you tell me about d mannose?

Here are some...: D-mannose is like a sugar and is used to treat carbohydrate-deficient glycoprotein syndrome - an inherited metabolic disorder. Urologically, it is thought to improve the integrity of bladder mucosa so to prevent bacteris sticking to bladder lining leading to lessen recurrent UTI, but its real effect for such has not been well verified. So, talk with doc why d-mannose is used for you. ...Read more

Dr. James Lin Dr. Lin
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Can you tell me anything about d mannose?

Dr. James Lin Dr. Lin
1 doctor agreed:
Can you tell me anything about d mannose?

Here are some...: D mannose is a kind of sugar as an important molecule to make bladder mucosa less sticky for bacteria so to minimize persistent or recurrent bacterial UTI. Though some studies said so, it is still not 100%. Will it help in this aspect? Maybe at best. The mainstay of bacterial UTI is still effective antibiotics + an emptying bladder + behavioral modification + occasionally long-term prophylactics. ...Read more

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Is d-mannose safe for early pregnancy?

Is d-mannose safe for early pregnancy?

It's unclear: To be honest there really isn't any significant evidence one way or the other. If you really want to be safe avoid it. Remember, especially with pregnancy, try to avoid taking anything you don't absolutely have to. ...Read more

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D-mannose safe in third trimester of pregnancy?

D-mannose safe in third trimester of pregnancy?

Drugs and prey: Depends on why you are taking it. In general no harm other than diuretic effects. Talk to your doctor. ...Read more

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What is this discharge after taking d'mannose? It burn and itch for two days, now it's just discharging..What can I take for that?

What is this discharge after taking d'mannose? It burn and itch for two days, now it's just discharging..What can I take for that?

See your doctor: All vaginal or other genital discharge problems need to be professionally examined in person. Depending on sexual lifestyle and risks, maybe an STD. See your doctor soon. ...Read more

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Can d-mannose treat bladder infections?

Can d-mannose treat bladder infections?

No way: Bladder infections require antibiotics & not a dietary suppliment that does nothing to eliminate or kill bacteria. ...Read more

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I took D-mannose for 2 days but i think i took too much. Felt discomfort and dull pain in kidneys. Feel better now. Did this harm my kidneys permanent?

I took D-mannose for 2 days but i think i took too much. Felt discomfort and dull pain in kidneys. Feel better now. Did this harm my kidneys permanent?

No: D-mannose is a type of sugar found in a number of fruits and available in dietary supplement form. Though typically touted as a natural remedy for E. coli UTIs, there is currently a lack of clinical trials testing the use of D-mannose supplements against UTIs. Possible side effects: bloating and diarrhea. Many web sites report possible kidney damage in high doses, but basis of this is unfounded. ...Read more

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Can I take antibiotics for UTI and D- Mannose at the same time?

Can I take antibiotics for UTI and D- Mannose at the same time?

If you want to but w: Why would you want to take D-mannose. I do not know of any benefit from this product..... I would encourage you to stop it. ...Read more

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Are mannose and hyaluronic acid safe to use under eyes in your late 20s? I'm really curious.

Are mannose and hyaluronic acid safe to use under eyes in your late 20s? I'm really curious.

Cosmetic: I would suggest you see your local Oculoplastic surgeon for best recommendation. Some times we do a cosmetic blepharoplasty with lower lid suspension and chemical peel with good results. ...Read more

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I had a very bad reaction to last antibiotic for UTI. Trying d-mannose instead this time. How much should I take a day to rid? 12hrs, no relief yet.

I had a very bad reaction to last antibiotic for UTI. Trying d-mannose instead this time. How much should I take a day to rid? 12hrs, no relief yet.

Not a good idea: d-Mannose works for some as UTI preventative by inhibiting attatchment of bacteria to bladder wall. There are plenty of different antibiotics to treat UTIs. Just avoid the one that caused such a bad reaction. Good Luck ...Read more