Doctor insights on:
Mannose Binding Lectin
A rare: Deficiency to affect someone clinically, deficiencies are more common. These help the immune system do its job in clearing certain infections. Treatment is experimental at this moment. ...Read more
Experimental: But intravenous infusion of purified mannose-binding lectin from a donor plasma is being used. ...Read more
Mannose binding: This genetic immune deficiency disorder makes people prone to recurrent infections such as uri, pneumonia and meningitis. Depending on the type of infection, the symptoms caused by the infections vary in frequency and severity. Unaware that vaccinations affect this in any way. ...Read more
I have mannose binding lectin deficiency - does this mean I am 'immunocompromised'? Is it safe to be around animals at a zoo?
Wash your hand: MBLD is a disorder of the "Complement" pathway of the immune system, which helps protect against certain types of bacteria (encapsulated). People with MBLD may be more susceptible to other germs as well. Talk to your doc about Pneumococcal and Meningococcal vaccines. As for the zoo, Salmonella is a particular risk. But enjoy the zoo--just wash hands and don't touch animals or stool! ...Read more
Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?
Yes: Mannose-binding lectin deficiency is a complement disorder. Low igm and subclass igg (in your case 3 ; 4) is a separate entity. With low immunoglobulins and no response to vaccines, ivig would be reasonable. See an immunologist to evaluate this. ...Read more
Should vaccines i'm very low in (tetanus, hib, men c, pneuomococcle) be given when I have mannose-binding lectin deficiency, low igm, igg3 and igg4?
Yes.: They may need to be given more than once if your immune response is compromised, but you're still safer with them than without. ...Read more
Here are some...: D-mannose is like a sugar and is used to treat carbohydrate-deficient glycoprotein syndrome - an inherited metabolic disorder. Urologically, it is thought to improve the integrity of bladder mucosa so to prevent bacteris sticking to bladder lining leading to lessen recurrent UTI, but its real effect for such has not been well verified. So, talk with doc why d-mannose is used for you. ...Read more
Here are some...: D mannose is a kind of sugar as an important molecule to make bladder mucosa less sticky for bacteria so to minimize persistent or recurrent bacterial UTI. Though some studies said so, it is still not 100%. Will it help in this aspect? Maybe at best. The mainstay of bacterial UTI is still effective antibiotics + an emptying bladder + behavioral modification + occasionally long-term prophylactics. ...Read more