Doctor insights on:
Malignant Fibrous Histiocytoma Prognosis
MFH: Malignant fibrous histiocytoma is an umbrella term used to describe a range of more specific sarcomas. Although many of these tumors have unique cytogenetic profiles, they are largely not hereditary. ...Read more
40 yrs ago: Malignant fibrous histiocytoma (MFH) was first described by pathologists in the early 1960s. By 1970 it was considered a specific form of soft-tissue sarcoma. Mulltiple subtypes have been characterized including storiform-pleomorphic, myxoid, giant cell, and inflammatory variants . It is now regarded as the single most common adult soft tissue sarcoma. ...Read more
Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?
Depends: A thymoma is a malignant tumor of the thymus, and the seriousness depends on details in the pathology report. An ectopic thymus and a hamartoma are both benign, but if the report says "thymoma" then it is probably malignant although not necessarily very serious if completely removed. Discuss with your surgeon! ...Read moreSee 1 more doctor answer
Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?
Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more
Yes: Many benign tumors are known to convert to malignancy and are carefully watched and not subject to treatment ie giant cell tumor of bone that is radiated will convert. Benign lipomas as they grow may be found to convert to liposarcoma and Pagets of bone is known to convert to Pagets sarcoma.Thyroid adenomas also have a high rate of conversion. ...Read more
Genetic component?: There could be genetic component to a squamous cell cancer, although the exact implications on treatment aren't known. Obviously if there is a strong family history of cancers, or if it strikes someone who is young and/or a non smoker/drinker i would suspect a strong genetic contribution. Without more details, it is hard to say with any certainty. ...Read moreSee 1 more doctor answer
Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?
Marker not prognosis: CK7 and calretinin are used to verify that the tumor is mesothelial in origin (versus adenocarcinoma of the lung). It does not provide information about prognosis. Factors associated with pleural mesothelioma prognosis include: functional status, blood counts, histology (epithelial best vs fibrosarcomatous poorest), and tumor size (degree of involvement of pleural cavity). Several new trials. ...Read more
If both benign and malignant tumours are formed by abnormal cell division, what makes malignant tumours cancerous and benign tumours non-cancerous?
Power to invade: Tumors are in fact caused by the accumulation of a series of genetic mutations. If something is going to be cancer, the mutations destabilize the genome and eventually mutations give the ability of the cells to invade and spread as they do early after conception. The idea that tumors are "cells dividing too rapidly" is fundamentally wrong and confusing -- it's the loss of controls. ...Read more
Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome. ...Read moreSee 2 more doctor answers
Many organs: The first likely tissue where metastases occurs in invasive ductal cancer is the lymph nodes on the armpit or behind the chest wall. Other organs may include the bones, lungs, liver, brain, adrenal glands, skin, bone marrow, the lining around the lungs or heart or the abdomen. Other parts of the body are less often sites of spread. ...Read more
Yes: Neurofibromatosis type 1 and type 2 are both hereditary diseases. Malignant tumors like sarcomas are a rare complication of neurofibromatosis. The technical name given to these are "malignant peripheral nerve sheath tumors, " and these are a type of sarcoma. Here's a link to a free full text article on the subject: http://theoncologist.Alphamedpress.Org/content/5/6/477.Full. ...Read more
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