Top
20
Doctor insights on: Malaria Selects For Sickle Cell Anemia

Share
1

1
Is malaria and sickle cell anemia related?

Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

See 2 more doctor answers
Dr. Heidi Fowler
359 doctors shared insights

Malaria (Definition)

A life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. These parasites infect red blood cells, causing high fever, shaking chills, sweats, vomiting, muscle pain, headache, anemia. First symptoms occur 10 days to four weeks post infection, symptoms occur in cycles of ...Read more


2

2
How did sickle cell anemia relate to malaria?

How did sickle cell anemia relate to malaria?

Malaria /sickle cell: In a person who has sickle-cell trait, the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” S ...Read more

See 2 more doctor answers
3

3
What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

See 1 more doctor answer
4

4
Are malaria and sickle cell anemia related? If so, how?

Are malaria and sickle cell anemia related? If so, how?

Yes: The mutation in sickle cell disease causes the red blood cell half-life to be shorter than normal. This can offer some protection against malaria because it disrupts the life cycle of the organism. This disease, along with thalassemias (which also shorten the red blood cell half-life), are prevalent in areas of the world that have high malaria rates. ...Read more

See 1 more doctor answer
5

5
How is it that sickle cell anemia formed because of malaria?

How is it that sickle cell anemia formed because of malaria?

Genetic Selection: Evolution. The sickle cell trait is adaptive when a red blood cell is infected with malaria. ...Read more

See 2 more doctor answers
6

6
Is sickle cell anemia prevalent where malaria doesn't exist?

Is sickle cell anemia prevalent where malaria doesn't exist?

Only here in the US: If you compare a MAP of malaria prevalence (number of cases) to a MAP of sickle cell disease prevalence, they are almost super-imposable with one exception; the United States. The prevalence of sickle cell anemia in the us is as high as some african countries with lower malaria frequencies, but our only malaria comes from travelers. ...Read more

7

7
I'm wondering why are carriers for sickle cell anemia resistant to malaria?

I'm wondering why are carriers for sickle cell anemia resistant to malaria?

Hgb S inhibits: Parasite growth in two ways. Increased sickling causes more rapid removal of infested red blood cells (suicide effect) and low oxygen in Hgb S RBC actually kills parasite. Thanks for trusting HealthTap! ...Read more

See 3 more doctor answers
8

8
Why are people who are heterozygous for sickle cell anemia more resistant to malaria?

Why are people who are heterozygous for sickle cell anemia more resistant to malaria?

Malaria: In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. Sickle Cell Trait can provide a protective advantage against P. Falciparum. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas > ...Read more

9

9
How are sickle cell anemia and malaria related? I've heard of an evolutionary advantage.

Sickle and malaria: Patients with sickle cell disease are protected againts severe and complicated malaria infection- by 2 mechanism: -1. Cells infected with malaria paracytes had accelerated sickling compared with noninfected cells- and as the result the cell would be destroyed/ promoting removal of infected cells from the circulation `2.Impaired paracyte growth due to reduce o2 content in sickle cell. ...Read more

See 1 more doctor answer
10

10
Why is it that carriers of sickle cell anemia are immune to malaria?

Can be infected: Having Sickle Cell traits doesn't actually mean that a person can't become infected w/ Malaria. But, it certainly helps with resistance. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16..." ...Read more

See 2 more doctor answers
11

11
Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

Sickle Cell /Malaria: In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” ...Read more

See 1 more doctor answer
12

12
Is sickle-cell anemia and malaria a virus or a bacteria spread disease?

Agree with Dr Diede: Sickle-cell trait & disease is an autosomal recessive inheritance from parents (genetics). Malaria is a parasitic infection. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life." ...Read more

See 1 more doctor answer
13

13
Is sickle cell anemia painful?

Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

14

14
Can I have sickle cell anemia?

Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

15

15
Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

See 2 more doctor answers
16

16
Why is sickle cell anemia painful?

Poor circulation: In sickle cell disease red cell stick together and block circulation to extremity and other organ so it cause pain crisis. ...Read more

17

17
How is sickle cell anemia detected?

Blood test: Every newborn baby undergoes "newborn screening" test before they are released from hospital. Most of abnormal hemoglobins, e.g. Hemoglobin s in sickle cell disease, are detected. ...Read more

See 1 more doctor answer
18

18
How dangerous is sickle cell anemia?

More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more

19

19
What are the tests for sickle cell anemia?

What are the tests for sickle cell anemia?

Hb electrophoresis: CBC and hemoglobin electrophoresis have to be done -at least- to make a diagnosis of sickle cell anemia. ...Read more

20

20
What is the symptoms of sickle cell anemia?

Anemia, pain, crises: The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others. Most patients that have sickle cell trait are completely asymptomatic. ...Read more

See 1 more doctor answer
Dr. James Ball
354 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more


Dr. Steven Ginsberg
1,276 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more