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Doctor insights on: Makes Metanephrine Test

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What makes the plasma metanephrine test different? 

What makes the plasma metanephrine test different? 

Different from urine: The plasma test compared to the urine is newer and more sensitive. In other words if you have pheochromocytoma the plasma test is less likely to miss the diagnosis by coming back normal. ...Read more

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Dr. Linda Callaghan
30 doctors shared insights

Metanephrines (Definition)

Metanephrins are metabolic products of cathecolamines: epinephrin and norepinephrin and can be used to diagnose excess production of these adrenal/sympathetic hormones. They can be measured in blood and urine and are very elevated in a condition called pheochromocytoma which is a tumor found mostly in the adrenal glands ...Read more


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What substances interfere with the plasma metanephrine test? 

What substances interfere with the plasma metanephrine test? 

Metanephrine: You should discontinue Epinephrine and epinephrine-like drugs for at least 1 week before the test, stop using Acetaminophen 48 hours beforehand, and fast for 8-10 hours prior to collection. It is especially important not to have any caffeine containing food (soda, chocolate), coffee (including decaf), tobacco (smoking cigarettes or cigars), tea, or alcohol for at least 4 hours before specimen coll. ...Read more

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What could a plasma metanephrines blood test mean if it is slightly elevated?

What could a plasma metanephrines blood test mean if it is slightly elevated?

Keep testing : Most labs are set up so that a few percent of healthies come out a bit high. You are getting worked up for pheochromocytoma, I bet. You will get seem real biochemical tests, and if others are suggestive, imaging. ...Read more

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Should the urine tests still be performed even though the plasma free metanephrine has been done? 

Should the urine tests still be performed even though the plasma free metanephrine has been done? 

Often no: The plasma has more sensitive and more specific and generally adequate (better) in most situations. It would depend if the doctor is more worried about a false positive (finding pheochromcystoma you really don't have), or more worried about false negative (missing the disease when you really have it). Your doctor would decide based on your symptoms which is the bigger worry /risk. ...Read more

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Renin , aldosterone , metanephrine and normetanephrine tests tells you what?

Renin , aldosterone , metanephrine and normetanephrine tests tells you what?

BP cause tests aldo: If they are high or low. Usually done looking for cause of high blood pressure or low blood pressure. Renin if low means Aldo or salt intake too high. If high suspect renal artery stenosis. Meta and nors are to test if you have a pheochromocytoma or other fatal tumor (if Dx missed) causing high BP. They can mean you are pregnant if both R and A high. If mets low may have SNS dysfunction ...Read more

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Why do I have to refrain from tobacco for catecholamines  and metanephrine urine test?

Why do I have to refrain from tobacco for catecholamines  and metanephrine urine test?

Nicotine...: Tobacco contains nicotine. Nicotine gives the body its kick because it stimulates the adrenal glands to produce adrenaline. Adrenaline, or epinephrine, is a catecholamine. If you use tobacco, the test may return as a false positive. ...Read more

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Renin , aldosterone , metanephrine and normetanephrine tests indicates what kind of condition?

Renin , aldosterone , metanephrine and normetanephrine tests indicates what kind of condition?

Arterial hypertensio: These are hormones closely related to blood pressure control secreted by the kidneys {renin} and the adrenal glands. They are vital for preservation of salt and therefore control the volume of the plasma as well as the tone of your small arteries the combination of these two plus cardiac pump action determines your blood pressure at all times. ...Read more

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What does it mean if my Metanephrines Total (244) and Nor/Epinephrines Totals (107) are Elevated in my urine? I just got an email from the lab that ran these tests.

What does it mean if my Metanephrines  Total (244) and Nor/Epinephrines Totals (107)  are Elevated in my urine? I just got an email from the lab that ran these tests.

Warrants followup: Most common reason urine metanephrines & catecholamines are checked is suspicion for pheochromocytoma, a rare adrenal gland tumor. For high levels not in pheo range (=norepi >170mcg/day epi >35/day,metanephrine>400/day), suspicion depends on risks; followup w doc is important.Some folks have higher levels normally, or are on meds interfering(TCAs, decongestants, amphetamines, antipsychotics,other) ...Read more