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Doctor insights on: Maintenance Therapy For Multiple Myeloma

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Treatment for relapsed myeloma?

Treatment for relapsed myeloma?

New agents: Pomalidomide and Kyprolis (carfilzomib) were recently approved for treatment of relapsed myeloma- should talk to a hematologist/oncologist for more details. ...Read more

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Dr. Heidi Fowler
133 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Is cortisone given for multiple sclerosis treatment?

Is cortisone given for multiple sclerosis treatment?

MS relapses: Steroids such as cortisone can be used to treat relapses, but should not be used chronically due to adverse event potential. These drugs should only be used briefly to reverse a flare. ...Read more

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What are the options for long-term maintenance therapy to prevent primary CNS lymphoma recurrence?

What are the options for long-term maintenance therapy to prevent primary CNS lymphoma recurrence?

Check out these: Links. Take care and god bless u! http://www.uptodate.com/contents/treatment-prognosis-and-prophylaxis-of-secondary-central-nervous-system-lymphoma. http://m.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/herbsvitaminsandminerals/index?sitearea=eto. ...Read more

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Are stem cell transplants for multiple myeloma effective?

Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more

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What are your treatment options for multiple myeloma?

Many: There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines: http://www.msmart.org/msmart_mar09_002.htm Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more

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How long are biphosphonates to be given for multiple myeloma?

Not clear: There is no correct answer for this. Many patients receiving bisphosphonates for active myeloma receive regular treatment for approximately 2 years . In some cases it may be given longer on a less frequent schedule. It may also be stopped or decreased in frequency if side effects develop. ...Read more

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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read more

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In peripheral neuropathy with thalidomide, is lenalidomide a good alternative for newly diagnosed multiple myeloma with velcade (bortezomib) dexamethasone?

In peripheral neuropathy with thalidomide, is lenalidomide a good alternative for newly diagnosed multiple myeloma with velcade (bortezomib) dexamethasone?

Possibly: Even though Lenalidomide causes less neuropathy it still occurs. Also depends on the disease. Meaning how aggressive does one need to be. Is there kidney dysfunction? Is the patient of transplant age? ...Read more

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Is revlimid (lenalidomide) effective in the use for treatment for acute myelogenous leukemia?

Is revlimid (lenalidomide) effective in the use for treatment for acute myelogenous leukemia?

Possibly: We do use it if they have chromosomal changes that predict response. However, not the standard of care. Mainly used if the person is not in the best of shape and looking for alternative, non aggressive options. Hope this helps. ...Read more

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Is there any treatment for cognitive impairment for multiple sclerosis?

Is there any treatment for cognitive impairment for multiple sclerosis?

You Bet There Is!!: First, you are better if taking a very potent ms medicine, such as tysabri (natalizumab) or gilenya, as "off label" both have shown ability to prevent brain atrophy, and improve fatigue and cognition. Second, have adequate levels of vit d, taking 5-10000 units daily. The traditional Alzheimer's meds do not help usually, but would consider a trial of 2 medical foods, axona, and cerefolin-nac, and ?Galantamine. ...Read more

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How many sessions and weeks are required for Cognitive behavioral therapy for weight-loss?

How many sessions and weeks are required for Cognitive behavioral therapy for weight-loss?

Ask the therapist: Actually, in my OPINION as a NON-psychiatrist....when it comes to something such as WEIGHT LOSS...if you're looking for a permanent fix....the MORE sessions you take....THE BETTER....all the way out to INDEFINITELY. However, the reality is that most providers will only go a certain number according to insurance limits so that's what it turns out to be but everyone's different. Ask your therapist ...Read more

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Treatment options for diffuse large b-cell lymphoma?

Treatment options for diffuse large b-cell lymphoma?

R-CHOP: The most common regimen is r-chop (rituximab, cytoxan, adriamycin, (doxorubicin) vincristine, prednisone). Other options are epoch-r, a clinical trial. There are several regimens, but the most common regimen is r-chop. It also varies on the stage of the disease. Hope this helps. ...Read more

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What other tests for multiple myeloma?

What other tests for multiple myeloma?

Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more

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Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or rituximab+bendamustine?

Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or  rituximab+bendamustine?

There is no: Definitive answer to your question. Studies have compared the strategies you mention. The high dose ara-c arm was closed because it was difficult to mobilize stem cells for transplant after these regimens. Bendamustine-r is a good program, and many centers would consolidate a good response with an autograft. ...Read more

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Does dmsa have use for multiple sclerosis treatment?

Does dmsa have use for multiple sclerosis treatment?

Unfortunately NOT: Many of my patients search diligently for an alternative approach to their ms. Dmsa, bee stings, usage of a antihistamine and caffeine preparation, and the more recent quest to operate on subcortical veins, seem to appear in the news. Unfortunately, none of these approaches help whatsoever. Best to use a potent disease modifying agent, and also supplement vitamin d-3. ...Read more

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What are treatments for relapse aml?

What are treatments for relapse aml?

Relapsed AML: Chemotherapy for relapsed AML depends on how soon after treatment the AML relapsed and what sort of drugs it responded to before. Many regimens are available. They include medications like cytarabine, mitoxantrone, etoposide, clofarabine, decitabine, & experimental agents available on clinical trials. The leukemia and lymphoma society website has information you may find useful. So does the nih. ...Read more

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What are promising new treatments for multiple sclerosis?

What are promising new treatments for multiple sclerosis?

Many: We have 12 drugs approved to treat MS, and more on the way. The newest are Tecfidera, Plegridy, and the most potent drug of all, Lemtrada. Coming are newer mono-clonal antibodies, a drug to restore myelin damage, and even some treatment for the progressive forms. ...Read more

Dr. Liawaty Ho
761 doctors shared insights

Multiple Myeloma (Definition)

A cancer that forms in a type of white blood cell ...Read more