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Macrophage Activation Syndrome
MAS.: Syndrome of uncontrolled proliferation and activation of macrophages and t lymphocytes, with marked increase in circulating cytokines (ifn-gamma, gm-cs). This is a serious disorder differentiated from flare of underlying disease by hypofibrinogenemia and therefore esr. Unknown cause, but associated with several juvenile rheumatic diseases such as still's disease and systemic lupus erythematosus. ...Read more
Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.
All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more
Severe infections: Such a term is not commonly used. Immune deficiency conditions may involved different components of the immune system. The cellular components are diverse and include lymphocytes, granulocytes and monocytes/macrophages. When deficient, severe infections occur, other problems such as cancers also occur in these conditions. A clinical immunologist/allergist should evaluate the immune system. ...Read moreSee 1 more doctor answer
Is there any known/suspected relationship between. Undifferentiated connective tissue disease and mast cell activation syndrome ?
Unaware: I am not aware of such a connection ...Read more
Glaucoma risk: Pigmentary dispersion is a syndrome where pigment is liberated from the back to the iris due to chaffing and is released into the aqueous humor. The pigment gradually obstructs the drainage apparatus of the eye and in about 30% of the time, may cause enough elevation in the eye pressure to cause glaucoma (pigmentary glaucoma). Its more common in younger myopic males. Treatment is available. ...Read more
What does an increased number of mast cells in stress-indiced urticaria biopsy indicate? Previously diagnosed w/connective tissue autoimmune disease.
Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more
Very ill: Patients (usually children) are very ill with frequent infections. Primary immunodeficiency (pi) causes children and adults to have infections that come back frequently or are unusually hard to cure. See 10 warning signs of primary immune deficiency http://www.Info4pi.Org/aboutpi/pdf/general10warningsignsfinal.Pdf. ...Read more
Affected nerves are:: Any peripheral sensory-motor branch of nerves that affect the anterior musculature of the leg and foot. Becuase gb causes upper motor nerve disruption of muscular function, the most affected nerves are those in the lower leg and foot that are part of the "swing" phase of gait, namely the extensor muscle of the foot and anterior tibialis muscle. The nerve roots affected are l3-l4-l5-s1. ...Read more
Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms
Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read moreSee 1 more doctor answer
Yes they Differ.: These are two separate conditions. Symptoms may be similar but the cause is different. In mastocytosis, patients have too many mast cells(MC). Because they are so plentiful, when one activates the other MC close by, will also release their chemicals (Histamine, Leukotrienes, prostaglandins, etc). MCAS is a condition that the numbers of MC are normal but overactive. Degranulating spontaneously. ...Read moreSee 1 more doctor answer
Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?
SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read moreSee 3 more doctor answers
Miscarriage: Apa, along with lupus anti-coagulant antibody, are two antibodies that attack the areas in the cell wall of growing tissue, especially the fast-growing placental tissue of an early pregnancy. These are newly-discovered causes for recurrent miscarriage, and are usually treated with Heparin injections and Aspirin during pregnancy. ...Read more
Can you have MCAS (Mast Cell Activation Syndrome) without an elevated tryptase level, even while symptomatic?
No: If you have symptoms and the tryptase is normal, it is highly unlikely to be from MCAS. However anaphylaxis to food is not always associated with elevated tryptase level. It would be helpful if you can provide us with a description on the types of symptoms you have been experiencing during the attack. ...Read more
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