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Macrophage Activation Syndrome
MAS.: Syndrome of uncontrolled proliferation and activation of macrophages and t lymphocytes, with marked increase in circulating cytokines (ifn-gamma, gm-cs). This is a serious disorder differentiated from flare of underlying disease by hypofibrinogenemia and therefore esr. Unknown cause, but associated with several juvenile rheumatic diseases such as still's disease and systemic lupus erythematosus. ...Read more
Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?
SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read moreSee 2 more doctor answers
Eating WBCs : Wbcs are infection/ca fighting cells. 5 different types circulate in the blood; in order of abundance: neutrophils, lymphocytes, monocytes, eosinophils & basophils. The neutrophils stay in the blood stream; the others hitch a quick ride in the blood stream but move all around the body. When monocytes leave the blood stream, they transform into macrophages which eat dead cells, bacteria, virus, etc. ...Read more
Voltage-gated: Sodium channels are normally found on the peripheral terminals of nocicpetors (sensory neuron). With tissue injury, the number of these sodium channels increases. When a noxious stimulus acts at the peripheral end of an axon, some sodium channels open to allow an influx of sodium into the cell leading to action potential and pain. ...Read more
Normal: Macrophages are a type of white blood cells (in the blood they are called monocytes). They are known for phagocytosing ('eating') foreign microscopic substances. Ductal hyperplasia is a benign proliferation of ducts usually described in breast biopsies. ...Read more
Likely good sized.: This helps to immortalize cell lines, and telomerase activity has been observed in roughly 90% of tumors, so it is likely to increase the risk of cancer considerably, also since this makes mutation of chromosomes much more possible. This also upregulates the role of 70 genes responsible for tumor growth and spread throughout the body, and the activation of glycolysis, so the cells can use sugar. ...Read moreSee 1 more doctor answer
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