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Doctor insights on: Macrophage Activation Syndrome

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What is macrophage activation syndrome ?

What is macrophage activation syndrome ?

MAS.: Syndrome of uncontrolled proliferation and activation of macrophages and t lymphocytes, with marked increase in circulating cytokines (ifn-gamma, gm-cs). This is a serious disorder differentiated from flare of underlying disease by hypofibrinogenemia and therefore esr. Unknown cause, but associated with several juvenile rheumatic diseases such as still's disease and systemic lupus erythematosus. ...Read more

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Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?

Can systemic inflammatory response syndrome  in a 5 year old with juvenile rheumatoid  arthritis cause macrophage activation  syndrome?

SIRS + JRA = MAS?: There is controversy as to whether macrophage activating syndrome is a real entity, versus it being confused for hemophagocytic lymphohistiocytosis (hlh). Hlh has much more defined criteria and can make a patient very sick (and requires chemo for treatment). A question i would have is could a patient with jra who develops sirs really have hlh. I would consult peds hem/onc (rheum mds may disagree). ...Read more

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What are macrophages doing in me?

What are macrophages doing in me?

Macrophages are the: Tissue phase of wbcs called monocytes. You can think of them as scavengers, helping to "clean up" areas of prior inflammation or infection. ...Read more

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What are macrophages and its functions?

What are macrophages and its functions?

Eating WBCs : Wbcs are infection/ca fighting cells. 5 different types circulate in the blood; in order of abundance: neutrophils, lymphocytes, monocytes, eosinophils & basophils. The neutrophils stay in the blood stream; the others hitch a quick ride in the blood stream but move all around the body. When monocytes leave the blood stream, they transform into macrophages which eat dead cells, bacteria, virus, etc. ...Read more

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In regard to health, what does macrophage mean?

In regard to health, what does macrophage mean?

Macrophage: Macrophages are immune cells that engulf foreign antigens/ materials & dead cells. ...Read more

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What causes ceroid macrophages in colonic biopsy?

What causes ceroid macrophages in colonic biopsy?

Aging, wear and tear: Ceroid is a "junk" material that builds up over time, created from the oxidation of some fatty lipids. Ceroid accumulates in macrophages (a type of cell that collects "junk" substances as the years go by) of the heart, artery plaques, liver, intestinal tract, and brain in elderly folks, and is thus called a "wear and tear" substance. It is believed to have a role in age-related organ dysfunction. ...Read more

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How can macrophages promote progression and malignancy in tumors?

How can macrophages promote progression and malignancy in tumors?

A specific subset: macrophages in the presence of malignancy are associated with the release of cytokines and TGF Beta. The associated inflammasome is tied into development and progression of tumor, possibly as a secondary mechanism for suppressing immune anti tumor activity. Tumor Associated macrophages (TAM) which are Notch-dependent are critical for tumor growth. ...Read more

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What are sodium channel activators used for?

What are sodium channel activators used for?

Voltage-gated: Sodium channels are normally found on the peripheral terminals of nocicpetors (sensory neuron). With tissue injury, the number of these sodium channels increases. When a noxious stimulus acts at the peripheral end of an axon, some sodium channels open to allow an influx of sodium into the cell leading to action potential and pain. ...Read more

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What are tissue plasminogen activators used for?

What are tissue plasminogen activators used for?

Dissolve blood clots: These are proteins that when added to blood bind to clots and dissolve them. ...Read more

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What is macrophages and cytologically bland of ductal hyperplasia?

What is macrophages and cytologically bland of ductal hyperplasia?

Normal: Macrophages are a type of white blood cells (in the blood they are called monocytes). They are known for phagocytosing ('eating') foreign microscopic substances. Ductal hyperplasia is a benign proliferation of ducts usually described in breast biopsies. ...Read more

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What is an activator procedure at the chiropractic office?

What is an activator procedure at the chiropractic office?

"hi-tech" hands-on..: Activator procedures are used to "chiropractically" adjust your spine with the assistance of an "activator"(which is a device that through spring tension delivers a "push" to the area). This is a form of 'manual medicine'. As with all chiropractors; only utilize those whom have a good rep; or you know is highly spoken of; let the buyer beware applies here. ...Read more

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Please explain plasminogen activator.?

Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

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How do macrophages start an immune response in the body?

How do macrophages start an immune response in the body?

They don't: They get summoned to an area where there is an inflammation by certain signals from the immune system, and they deal with situation at hand, their main job is to contain damage and digest foreign or damaged cells, in a nutshell ...Read more

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Does hCG activator pills have estrogen?

Sorry: But there are no HCG activator pills that activate anything, except the transfer of money out of your wallet. Besides, who knows what's in the pills or what harm they could do to you. Why do you think you need your HCG "activated" in the first place. Even if they worked, they wouldn't help you. Don't get your medical information from friends, tv or the internet. ...Read more

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How much cancer risk is there taking a telomerase activator?

How much cancer risk is there taking a telomerase activator?

Likely good sized.: This helps to immortalize cell lines, and telomerase activity has been observed in roughly 90% of tumors, so it is likely to increase the risk of cancer considerably, also since this makes mutation of chromosomes much more possible. This also upregulates the role of 70 genes responsible for tumor growth and spread throughout the body, and the activation of glycolysis, so the cells can use sugar. ...Read more

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A tissue plasminogen activator is what?

A tissue plasminogen activator is what?

Fibrinolytic: Tissue plasminogen activator (tpa) is a serine protease (enzyme) that catalyzes the reaction that converts plasminogen to plasmin. Plasmin is responsible for breaking down blood clots by cleaving molecules of fibrin, creating "fibrin degradation products". ...Read more

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Could i take hgc activator (diet pill) soon after delivering a baby?

Could i take hgc activator (diet pill) soon after delivering a baby?

Diet pill: Please don't take diet pills! There are many diet options that are very good for you. You will find many related articles on the web and learn a lot. My personal preference is "NuVal" which is easy to follow but the other ones are also very good. Congrats on a new baby. ...Read more

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Could you take hgc activator (diet pill) soon after delivering a baby?

Could you take hgc activator (diet pill) soon after delivering a baby?

Be sure to only: take the ones that say they have been FDA approved. Nearly all of them say "NOT FDA approved." or "These statements have not beenevaluated by the FDA" "This product is not intended to diagnose, treat..." Don't get those ones. ...Read more