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Doctor insights on: Macrocytic Normochromic Anemia Causes

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Dr. Steven Ginsberg
1,285 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more


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What can cause normocytic normochromic anemia in a 2-year-old female with a history of poor growth for the past ~6 months and autism?

What can cause normocytic normochromic anemia in a 2-year-old female with a history of poor growth for the past ~6 months and autism?

Mgt: One consideration is chronic or systemic disease states. Has she been screened for Cystic Fibrosis? A virtual consult may be arranged so that you can upload the growth chart and lab results. ...Read more

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Can iron help reduce normochromic anemia?

Can iron help reduce normochromic anemia?

IDA and Fe: Iron can help improve iron deficiency anemia (ida). Usually ida is associated with red blood cells (rbcs) that are hypochromic (=pale), microcytic (small cells). However, anemia may be mutifactorial (many causes) and may result in a lab value of normocytic (normal sized) rbcs. A peripheral blood smear and iron studies (ferritin, etc) will help evaluate. ...Read more

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What's a normocytic normochromic anemia?

What's a normocytic normochromic anemia?

Normal looking cells: Normocytic means the red blood cells are normal size; normochromic means normal color (amount of hemoglobin which gives the red blood cells their red color. Anemia means you have fewer than the normal number of red blood cells. ...Read more

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How is normocytic normochromic anemia a threat to someone 's life?

How is normocytic normochromic anemia a threat to someone 's life?

See below: Any type of anemia can have various complications if left untreated but it depends heavily on the type of anemia and its cause. Normocytic normochromic anemia is frequently associated with an underlying chronic disease and it is very important to diagnose this disease in order to know what the complications may be and how to treat them. ...Read more

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Smear shows mild normocytic normochromic anemia. What does this mean?

Smear shows mild normocytic normochromic anemia. What does this mean?

Need more info: A mild normochromic, normocytic anemia will be diagnosed on the machine-generated counts with confirmation from the smear. It means you need a workup to find the cause, and that while things aren't severe yet in the blood, at your age it may well be the wakeup call for a treatable cancer. ...Read more

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Are there any treatments for a patient with microcytic normochromic anemia?

Are there any treatments for a patient with microcytic normochromic anemia?

Maybe: It all depends upon finding the cause- then treatment can be formulated. How important this is depends upon the severity of the anemia and all of your other medical conditions. There are many potential causes of this from early iron deficiency to drug effects to inflammation hidden or otherwise- you should be seeing a hematologist. ...Read more

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What does mild normocytic normochromic anemia for age and sex and absolute lymphopenia mean?

Anemia: Anemia refers to your hemoglobin and hematocrit (packed cell volume) levels. Essentially these tell you whether you have enough red blood cells. Your red cells are normal (normocytic) and have a normal amount of hemoglobin (normochromic). Causes include aplastic, posthemorrhagic, and hemolytic anemias and anemia of chronic disease. Lymphopenia = decreased lymphocytes. ...Read more

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What does normocytic, normochromic anemia (hgb 11.5) w/increased rdw, retic and hgb F 7.1 mean in a 5-year-old? I'm very concerned. Dr said not urgent

What does normocytic, normochromic anemia (hgb 11.5) w/increased rdw, retic and hgb F 7.1 mean in a 5-year-old? I'm very concerned. Dr said not urgent

Not urgent means...: The doctor is saying, "Don't worry, it's not dangerous. I'll tell you if and when it's time to worry." Listen to the doctor (unless there is a valid reason not to listen to the doctor). Hgb is hemoglobin, and there are several types. If a child is growing and behaving fine, and already 5 years old, he likely has nothing urgent because he has lived happily with his hemoglobin type for 5 years. ...Read more

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How do normocytic normochromic anemia and leukemia go hand in hand?

Variable: Hi
Great question, there's a deeper answer, but generally leukemias usually affect the white blood cell line, rather than the red blood cell lineage. What you're probably referring to is called "anemia of chronic disease". Elevated inflammatory mediators, like IL-6, impair both production and ability to incorporate iron into heme, which causes normocytosis and normochromia. Hope this helps ...Read more

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58+ F Hb 10.8, RBC "Predominantly macrocytic normochromic with macroovalocytes". Ferritin 100 ng/ml, B12 894 pg/ml, Folic Acid 12.3 ng/ml. Why Anemia?

58+ F Hb 10.8, RBC "Predominantly macrocytic normochromic with macroovalocytes". Ferritin 100 ng/ml, B12 894 pg/ml, Folic Acid 12.3 ng/ml. Why Anemia?

Hg 10.8 macrocytic: Tested methylmalonic acid? Homocystine,? They are usually elevated before B12 goes down, though your B12 is pretty normal. Are you on any medications? Metformin? HIV? Alcohol? Hypothyroidism, liver disease, COPD, G6PD, hemolysis, malabsorption (usually have low B12 as well) can cause it as well.

http://www.aafp.org/afp/2009/0201/p203.html
f/u/ w/ hematology ...Read more

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Can normochromic or normocytic anemia cause leukemia?

Can normochromic or normocytic anemia cause leukemia?

No: Anemia (normochromic/cytic or not) can be a sign of leukemia (or a variety of other cancerous or non-cancerous conditions). That is it can associated with leukemia. However, it does not cause leukemia. Correlation does not equal causation. ...Read more

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What are the causes of macrocytic hypochromic anemia?

What are the causes of macrocytic hypochromic anemia?

See below: Macrocytic anemia has several causes. Most common causes are vitamins B12 and folate (folic acid) deficiency, liver disease, alcohol excess. There are other less common causes. ...Read more

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Does hypothyroidism cause macrocytic anemia in elderly. Can Hb reach 8.5 due to hypothyroidism.

Does hypothyroidism cause macrocytic anemia in elderly. Can Hb reach 8.5 due to hypothyroidism.

Yes: Hypothyroidism can cause macrocytic anemia. This anemia is due to poor nutrition and/or poor absorption of folate and B12. Thyroid hormones assist in that absorption, so low levels of T3 (liothyronine) and T4 can lead to that anemia. Treatment should not only address the anemia, but also the hypothyroidism. ...Read more

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Am 70yrs. I had bad depresion for 14 month, eat once daily and sleep 3 hrs. Does that cause macrocytic anemia. B12, folic ok. Can it be bad absorption?

Am 70yrs. I had bad depresion for 14 month, eat once daily and sleep 3 hrs. Does that cause macrocytic anemia. B12, folic ok. Can it be bad absorption?

Yes.: I may have answered this already . Depression can cause poor appetite and may cause malnutrition over a long period. However, if your B12 and Folic Acid are normal, then I do not believe you have macrocytic anemia. The cause of macrocytic anemia is due to the absence of intrinsic factor in your stomach causing malabsorption of nutrients that can cause macrocytic anemia. ...Read more

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Can hpylori bacteria cause macrocytic anemia for 70 yrs man. Had it from 2 yrs and treated. Folic, B12 ok. Can it be no absorption though normal vit.?

No: H. Pylori does not causes macrocytosis. If B12 is below 400, consider checking methylmalonic acid as it still could be B12 deficiency. In a 70-year old, maxrocytosis could be a sign of bone marrow disorder, called myelodyspalstic syndrome. Also, certain drugs can cause macrocytosis. ...Read more

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Can a bleeding ulcer cause macrocytic hypochromic anemia?

Usually not: Because it causes and iron deficiency anemia, which is microcytic. You should be tested for other conditions, so see your doctor for details. ...Read more

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What are all the causes of moderate macrocytic anemia in elederly other than vitamin B12 and folic acid defficiency. Can severe depression cause that?

What are all the causes of moderate macrocytic anemia in elederly other than vitamin B12 and folic acid defficiency. Can severe depression cause that?

Depression>poor eatg: Anemia should not be accepted as an inevitable consequence of aging. A cause is found in approximately 80 percent of elderly patients. The most common causes of anemia in the elderly are chronic disease and iron deficiency. Vitamin B12 deficiency, folate (folic acid) deficiency, gastrointestinal bleeding and myelodysplastic syndrome are among other causes of anemia in the elderly. Serum ferritin is the most us. ...Read more

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What are the causes of macrocytic anemia for elderly? If no vitamins defficiency, no RBC breakdown, no thyroid and liver problems & normal wbc

See hematologist: As my previous answer, your dad should see a hematologist for his anemia. Work-up including a bone marrow biopsy should be done- one of the thing we should rule out is possibility of myelodysplastic syndrome. However, we are not able to give you more specific answer without seeing all the complete result of previous work-up and examining your father. So, start by asking pmd to refer to hematologist. ...Read more

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Does nomochromic normocytic anemia indicate renal impairment?

Not necessarily: Normocytic normochromic anemia can be caused by acute blood loss, early iron deficiency, bone marrow supression, anemia of chronic disease, anemia of renal insufficiency, anemia caused by endocrine problem etc. ...Read more

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What are macrocytic anemia and mild absolute leukocytopenia?

Both are ways of....: Describing features of blood cells. Anemia means your red cell mass is 2 standard deviations below the lower norm for age and sex. Macrocytic means the rbcs are bigger than expected (normal red cell size falls within a normal range) and size gives us clues as to the cause of the anemia. Leukopenia means your total WBC count is below normal. A differential is really needed to interpret leukopenia. ...Read more

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What is considered abnormal retic count for a 70 yrs man with macrocytic anemia? His Hb is 9. His retic count .85% and retic shape is normal.

What is considered abnormal retic count for a 70 yrs man with macrocytic anemia? His Hb is 9. His retic count .85% and retic shape is normal.

Depends.: Retic count should be 1% with a normal Hgb. For a 70 y/o male, that would be about 13. As Hgb goes down young red cells (retics) should go up to correct the deficit. In this case about 2.5 — 3% at least. 0.85% shows poor RBC production. With macrocytosis (large RBCs) consider B12, folate (folic acid) deficiency, certain drugs, liver disease, low thyroid, myelodysplastic syndrome & other bone marrow disease ...Read more

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Which type of anemia is more serious and could be due to bloo cancer? Is it macrocytic or microcyyoc anemia? Mcv 107 is it too high? Thanks

Both: Microcytic anemia is most often due to iron deficiency and blood loss. Macrocytic anemia(mcv over 96) can be due to vitamin B12 or Folic Acid deficiency, alcoholism, liver disease, some bone marrow disorders like leukemia, underactive thyroid or rarely fish tapeworms. All anemias are dangerous if not properly diagnosed and treated. A hematologist is consulted if the cause of the macrocytosis is vague. ...Read more

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Dad 70 yrs old has macrocytic anemia. All else normal. Hos hb went up from 9.2 to 10.2 in two month without medicine. Does that rule out mds?

Not really...: The presence of macrocytic anemia should be investigated further. It is true that it could be a sign of mds but other causes are possible including vitamin b12/folate deficiency. His hemoglobin is still low and the fact it went up a little does not really rule out anything. ...Read more