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Doctor insights on: Macrocytic Hyperchromic Anemia Causes

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What are the causes of macrocytic hypochromic anemia?

What are the causes of macrocytic hypochromic anemia?

See below: Macrocytic anemia has several causes. Most common causes are vitamins B12 and folate (folic acid) deficiency, liver disease, alcohol excess. There are other less common causes.

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Dr. Steven Ginsberg
1,278 Doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more


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Does hypothyroidism cause macrocytic anemia in elderly. Can Hb reach 8.5 due to hypothyroidism.

Does hypothyroidism cause macrocytic anemia in elderly. Can Hb reach 8.5 due to hypothyroidism.

Yes: Hypothyroidism can cause macrocytic anemia. This anemia is due to poor nutrition and/or poor absorption of folate and B12. Thyroid hormones assist in that absorption, so low levels of T3 (liothyronine) and T4 can lead to that anemia. Treatment should not only address the anemia, but also the hypothyroidism.

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Am 70yrs. I had bad depresion for 14 month, eat once daily and sleep 3 hrs. Does that cause macrocytic anemia. B12, folic ok. Can it be bad absorption?

Am 70yrs. I had bad depresion for 14 month, eat once daily and sleep 3 hrs. Does that cause macrocytic anemia. B12, folic ok. Can it be bad absorption?

Yes.: I may have answered this already. Depression can cause poor appetite and may cause malnutrition over a long period of time. However if your B12 and Folic Acid are normal, then I do not believe you have macrocytic anemia. The cause of macrocytic anemia is due to the absence of intrinsic factor in your stomach causing malabsorption of nutrients that can cause macrocytic anemia.

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Can hpylori bacteria cause macrocytic anemia for 70 yrs man. Had it from 2 yrs and treated. Folic, B12 ok. Can it be no absorption though normal vit.?

Can hpylori bacteria cause macrocytic anemia for 70 yrs man. Had it from 2 yrs and treated. Folic, B12 ok. Can it be no absorption though normal vit.?

No: H. Pylori does not causes macrocytosis. If B12 is below 400, consider checking methylmalonic acid as it still could be B12 deficiency. In a 70 year old, maxrocytosis could be a sign of bone marrow disorder, called myelodyspalstic syndrome. Also, certain drugs can cause macrocytosis.

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Can a bleeding ulcer cause macrocytic hypochromic anemia?

Can a bleeding ulcer cause macrocytic hypochromic anemia?

Usually not: Because it causes and iron deficiency anemia, which is microcytic. You should be tested for other conditions, so see your doctor for details.

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What are all the causes of moderate macrocytic anemia in elederly other than vitamin B12 and folic acid defficiency. Can severe depression cause that?

What are all the causes of moderate macrocytic anemia in elederly other than vitamin B12 and folic acid defficiency. Can severe depression cause that?

Depression>poor eatg: Anemia should not be accepted as an inevitable consequence of aging. A cause is found in approximately 80 percent of elderly patients. The most common causes of anemia in the elderly are chronic disease and iron deficiency. Vitamin B12 deficiency, folate (folic acid) deficiency, gastrointestinal bleeding and myelodysplastic syndrome are among other causes of anemia in the elderly. Serum ferritin is the most us.

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What are the causes of macrocytic anemia for elderly? If no vitamins defficiency, no RBC breakdown, no thyroid and liver problems & normal wbc

What are the causes of macrocytic anemia for elderly? If no vitamins defficiency, no RBC breakdown, no thyroid and liver problems & normal wbc

See hematologist: As my previous answer, your dad should see a hematologist for his anemia. Work-up including a bone marrow biopsy should be done- one of the thing we should rule out is possibility of myelodysplastic syndrome. However we are not able to give you more specific answer without seeing all the complete result of previous work-up and examining your father. So, start by asking pmd to refer to hematologist.

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What are macrocytic anemia and mild absolute leukocytopenia?

Both are ways of....: Describing features of blood cells. Anemia means your red cell mass is 2 standard deviations below the lower norm for age and sex. Macrocytic means the rbcs are bigger than expected (normal red cell size falls within a normal range) and size gives us clues as to the cause of the anemia. Leukopenia means your total WBC count is below normal. A differential is really needed to interpret leukopenia.

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What is considered abnormal retic count for a 70 yrs man with macrocytic anemia? His Hb is 9. His retic count. 85% and retic shape is normal.

What is considered abnormal retic count for a 70 yrs man with macrocytic anemia? His Hb is 9. His retic count. 85% and retic shape is normal.

Depends.: Retic count should be 1% with a normal Hgb. For a 70 y/o male, that would be about 13. As Hgb goes down young red cells (retics) should go up to correct the deficit. In this case about 2.5 - 3% at least. 0.85% shows poor RBC production. With macrocytosis (large RBCs) consider B12, folate (folic acid) deficiency, certain drugs, liver disease, low thyroid, myelodysplastic syndrome & other bone marrow disease

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Which type of anemia is more serious and could be due to bloo cancer? Is it macrocytic or microcyyoc anemia? Mcv 107 is it too high? Thanks

Both: Microcytic anemia is most often due to iron deficiency and blood loss. Macrocytic anemia (mcv over 96) can be due to vitamin B12 or Folic Acid deficiency, alcoholism, liver disease, some bone marrow disorders like leukemia, underactive thyroid or rarely fish tapeworms. All anemias are dangerous if not properly diagnosed and treated. A hematologist is consulted if the cause of the macrocytosis is vague.

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Dad 70 yrs old has macrocytic anemia. All else normal. Hos hb went up from 9.2 to 10.2 in two month without medicine. Does that rule out mds?

Dad 70 yrs old has macrocytic anemia. All else normal. Hos hb went up from 9.2 to 10.2 in two month without medicine. Does that rule out mds?

Not really...: The presence of macrocytic anemia should be investigated further. It is true that it could be a sign of mds but other causes are possible including vitamin b12/folate deficiency. His hemoglobin is still low and the fact it went up a little does not really rule out anything.

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Reticulocyte count is. 85% for a 70 years old man with macrocytic anemia. Hb is 9 and MCV is 105. Is the reticulocyte count normal?

Reticulocyte count is. 85% for a 70 years old man with macrocytic anemia. Hb is 9 and MCV is 105. Is the reticulocyte count normal?

Probably not: In patients without anemia, a normal retic count is 1%. As anemia develops, if the marrow can respond, the retic count should rise, meaning more red blood cells are being made. Whatever is causing your anemia (with an elevated MCV), such as B12 deficiency or other causes, is also inhibiting your bone marrow from making new cells and thus your retic count is inappropriately low.

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If platelts and WBC are normal. Just macrocytic anemia. Hb 10, RBC 2.8. 70 yrd old. Suppose mds. Health great. Prognosis of such mds? Thanks

Anemia in theelderly: You are jumping into wrong conclusion. Many causes besides myelodysplasia causing macrocytic anemia; alcoholism, hypothyroid, cancer stomach, chronic liver disease, drugs, hemolysis. If you are to have myelodysplasia hemoglobin is one of five criteria to set the risk group so risk stratification needs bone marrow studies to check for blast percentages and cytogenetics and platelets.

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What is relation between severe depression and macrocytic anemia. I ate very little for year and lost 10 kg but all vit. Test ok. Am 70 yrs?

What is relation between severe depression and macrocytic anemia. I ate very little for year and lost 10 kg but all vit. Test ok. Am 70 yrs?

Not directly.: There is no direct correlation. Depression can cause poor nutrition due to loss of appetite and when depressed long enough can cause marked debility due to malnutrition. Pernicious anemia is caused by the lack of intrinsic factor in the stomach which causes malabsorption of essential vitamins especially b12. B12 can be better absorbed by using sublingual drops or subcutaneous injections.

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Should you stop drinking alcohol if you have macrocytic anemia (increased mcv)?

Should you stop drinking alcohol if you have macrocytic anemia (increased mcv)?

See below: Excessive alcohol intake can cause liver disease which can cause macrocytic anemia. Also people people who drink lots of alcohol could have nutrient and vitamin deficiencies such as vitamin b 12 and folic acid, and deficiencies from these can also cause macrocytic anemia. It's okay to have a drink now and then though.

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My dad 70 yrs has macrocytic anemia. Hemoglobin 9.5, hematocrit 28. Hematologist gave maltofer pill a day. In a month hemoglobin 10 hematocrit 30?

My dad 70 yrs has macrocytic anemia. Hemoglobin 9.5, hematocrit 28. Hematologist gave maltofer pill a day. In a month hemoglobin 10 hematocrit 30?

What is the question: Please rephrase your question to get a better answer. Please discuss in detail with his hematologist. The fact that hematologist gave the iron- means that your hematologist thinks there is a component of iron deficiency. So, continue iron and f/u with your md. However, it does not fit exactly with macrocytosis. Other work up still needs to be done to see explanation for macrocytosis.

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58+ F Hb 10.8, RBC "Predominantly macrocytic normochromic with macroovalocytes". Ferritin 100 ng/ml, B12 894 pg/ml, Folic Acid 12.3 ng/ml. Why Anemia?

Hg 10.8 macrocytic: Tested methylmalonic acid? Homocystine,? they are usually elevated before B12 goes down, though your B12 is pretty normal. Are you on any medications? metformin? HIV? alcohol? Hypothyroidism, liver disease, COPD, G6PD, hemolysis, malabsorption (usually have low B12 as well) can cause it as well. Http://www. Aafp. Org/afp/2009/0201/p203.html f/u/ w/ hematology

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Can macrocytic anemia be due to colon cancer? Mcv 103 and hemoglobin 9.8 for old male. I know only microcytic anemia aan be due to colon cancer?

Can macrocytic anemia be due to colon cancer? Mcv 103 and hemoglobin 9.8 for old male. I know only microcytic anemia aan be due to colon cancer?

Yes it depends: You are right that anemia from blood loss like from colon cancer is typically microcytic with a low MCV but the MCV in your case is not high enough to suspect a typical macrocytic anemia like one due to B12 deficiency. Yet we can have a mixed picture. At the moment we are only guessing all this till you have the right investigating/testing done. So I would check your B12 level and bone marrow exam.