Doctor insights on:
M Spike In Gamma Region Immunoglobulin
Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?
Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?
?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more
Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?
Monoclonal: •multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more
Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?
Serum free light chains increased ratio normal. lambda immunofixation with 4% m spike in beta 2 region in urine only. recommended next step 4 anemia?
Spike in UPEP: If you have an abnormal M spike on your urine protein electrophoresis (UPEP), that suggests there is some abnormal cells making excess gamma globulin ( a monoclonal gammopathy). A next step would normally include a bone marrow aspirate and biopsy - this reveals what the abnormality of the blood forming cells causing this is. ...Read more
Ideop Neurop, IPE=Monoclonal IGGlambada present. No free lambda light chains seen. Mprotein seen below threshold IPE. SI all in ranges Igg 1.4. mean?
Neuropathy in MGUS: Periphral neuropathy is common in gammopathies. If just sensory (numbness/tingling) we follow it or treat symptoms. If there is motor involvement (muscle weakness) it may need treatment. Risk of converson to a bone marrow disease is about 1% per year. You need to be followed by a neurologist/rheumatologist (if interested in neuropathies). MGUS means monoclonal gammopathy of unknown signifcance. ...Read more
No: M spikes are monoclonal. The gamma region in polyclonal gammopathies is broad and consist of more than 1 gammaglobulin. ...Read more
Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?
No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more
What low grade lymphoma am i expecting with tiny IgM kappa monoclonal protein in beta 2 region? I had bladder polyp removed last year, related?
Polyp not due to IgM: People with igm monoclonal gammopathy don't necessarily develop lymphoma, esp. If the m-spike is small. Options are it remains unchanged for years, it turns into a low-grade lymphoma like waldenstrom's macroglobulinemia or marginal zone lymphoma, it turns into chronic lymphocytic leukemia, or it causes nerve damage (neuropathy). All of these things are treatable with new options emerging rapidly. ...Read more
What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?
Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read moreSee 1 more doctor answer
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more
Blood work shows gam globulin low at 0.7 and M-spike,SPE, g/fl abnormal at 0.3. Two para protein bands in gam. Region. How serious is this?
Need more info: I am assuming that you had a serum electrophoresis performed for one reason or another. The "normal" and "abnormal" in this case can only be judged in context rather than in absolutes, so more information is necessary. Did you have a urine electrophoresis? Any other results? Free light chains? Did your doctor state that you have protein in the urine? ...Read more
Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read moreSee 1 more doctor answer
High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC
Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?
Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more
Gamma Globulin 1.8 slightly high
The rest normal.
No paraprotien spike seen.
IGE Serum 151 H
IgG 1768 H
Should I worried do i have MM .
Get monitored: This elevated IgG is compatible with MM which requires monitoring by an oncologist. Not to be too worried but to be more aware. ...Read more
Can you explain my lumbar puncture results - CSF alpha Feto protein 0.555 Beta HCG 0.322(iu/l) I have a pineal tumour. Tested CSF for germ cell.
These values are OK: These levels do not look out of ordinary. You need to relate these levels to previous levels of these markers. if they were high before then this test might have some meaning. Your oncologist is your best guide to explain what it all means. ...Read more
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