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Doctor insights on: Lyrica Vs Savella For Fibromyalgia

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Tried numerous meds for fibro like lyrica, cymbalta, gabapentin, savella (milnacipran). None work, not fibromyalgia?

Tried numerous meds for fibro like lyrica, cymbalta, gabapentin, savella (milnacipran). None work, not fibromyalgia?

Fibromyalgia: Certainly the diagnosis may not be correct. Make sure you have had a Rheumatology work -up. Also it may be that the meds are just not working on you.

Dr. Laurence Badgley
1,358 Doctors shared insights

Fibromyalgia (Definition)

Widespread pain and tenderness on palpation of specific muscle points, associated with variety of other symptoms that include fatigue, sleep disturbances, depression, ...Read more


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I have fibromyalgia but cannot take lyrica (pregabalin) what else is there?

I have fibromyalgia but cannot take lyrica (pregabalin) what else is there?

Antidepressants: I have found antidepressants most helpful. Particularly ones that are dual action like Effexor (venlafaxine) and Cymbalta also tricyclics like nortriptyline. These help with sense of wellbeing and fatigue. Also getting good sleep helps. I use trazodone 50mg for this part.

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I was diagnosed with fibromyalgia. I took affexor &lyrica for 1year but I stop medicine 3 mon ago since no pain. I ve some if I slept on hard mattress?

I was diagnosed with fibromyalgia. I took affexor &lyrica for 1year but I stop medicine 3 mon ago since no pain. I ve some if I slept on hard mattress?

Cured, at least for: Cured at least for present. If an activity causes pain, how important is that activity. If not important, avoidance is the best approach.

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Is it preferable to continue having lyrica (pregabalin) for fibromyalgia? Now my pain is better. Should I replace it with another medicine after 4 months?

Is it preferable to continue having lyrica (pregabalin) for fibromyalgia? Now my pain is better. Should I replace it with another medicine after 4 months?

If it works, do it!: Fibromyalgia is generally forever. The cause of nerve hypersensitivity is unknown but fibromyalgia patients nerves do not function like other people's. If your pain is better on lyrica, (pregabalin) do not stop it unless you are having side effects. Temporary fluctuations in fibro pain occur but significant relief is to be treasured. If it ain't broke, don't "fix" it!

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Should I continue takin effector & lyrica (pregabalin) 75 mg even that I am now better from fibromyalgia. What if I stop them now. Should I take them all of my life?

Should I continue takin effector & lyrica (pregabalin) 75 mg even that I am now better from fibromyalgia. What if I stop them now. Should I take them all of my life?

DEFINITELY!!!!!!: Yes you should continue the medications as the fibromyalgia is a chronic and lifelong condition. Your doses are very low so if these are effective I would definitely stick with it.

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Do I have to take venlax75mg and lyrica (pregabalin) 75mg as well, each 1 pill a day if I am diagnosed with fibromyalgia. I feel so much better. Take all my life long?

Why use 2 meds?: You are on rather low dosing, and one or the other meds alone may do very well if dose is adjusted. Best to keep it simple, so have long discussion with your doctor and pick where efforts need to be focused.

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I was diagnosed with fibromyalgia 1 year ago. I tookeffexor 75 &lyrica (pregabalin) 75 one pill a day& I felt better. Now I stopped takin lyrica (pregabalin) but I am feelin pain?

I was diagnosed with fibromyalgia 1 year ago. I tookeffexor 75 &lyrica (pregabalin) 75 one pill a day& I felt better. Now I stopped takin lyrica (pregabalin) but I am feelin pain?

Get back on Lyrica (pregabalin).: Lyrica (pregabalin) has been shown to be effective in treating fibromyalgia pain, but usual doses are 150 mg. Three times a day. Effexor is not shown to be effective but may improve your mood. Usual doses are around 300 mg. A day. It is pretty certain that 75 mg of Effexor will not be helpful for fibromyalgia pain. You must continue to take the Lyrica (pregabalin) to get benefit.

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What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

It depends: Every fibromyalgia patient is different and a medicine that works for one patient may not work for another. Cyclobenzaprine (flexeril) is a muscle relaxant that belongs to a class of drugs called the tricyclic antidepressants. Lyrica (pregabalin) is a seizure medicine that is also used to treat pain. While many patients benefit from these medicines, others don't tolerate them. You will have to try.

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Is there a more effective medication than lyrica (pregabalin) for fibromyalgia pain?

It is individual: Lyrica (pregabalin) at night can help pain and improve sleep in some fm patients. However, Lyrica (pregabalin) does not help others and can cause side effects that limit effectiveness. Since all fm patients are different, individualized treatment is necessary. Find a provider who will work with you to find the most effective treatment for your fibromyalgia.

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I hate lyrica's side effect but they r saying its the best for fibromyalgia is it true? Do I need to start using it or when should I start?

Not always: Lyrica (pregabalin) is only one option and there are several other meds which can very effective in the treatment of fibromyalgia. Many people do not tolerate lyrica (pregabalin). Get another opinion if your doctor will not discuss options with you.

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I have a problem gaining weight on medications so is there anything else you can take for fibromyalgia other than Lyrica (pregabalin)? Thank you.

Yes there are: Unfortunately, weight gain is common with many of the oral medications used in the treatment of FBS. Medications in the same classes have differing degrees to which they contribute on an individual basis. Following is a list of different classes and examples of each: AED- Lyrica, (pregabalin) gabapentin, Topamax. TCA-Doxepin, amitriptyline. SNRI-Cymbalta, venlafaxine. Topamax often causes weight loss.

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What do u mean by titrating meds from lower doses. I used to take effexor&lyrica 75mg one pill/day each coz of fibromyalgia. I used 2 stop meds 3months?

Talk to doc.: It is best to speak to the prescribing physician! Lyrica (pregabalin) is often begun at 75 mg twice daily for fibromyalgia. Effexor is often titrated, at least the xr formulation, beginning at 37.5 for one week, then 75mg for one week before further titration depending on the target dose.

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How could I restart my meds of fibromyalgia because of recurrence of symptoms. I used to take effexor&lyrica 75mg each/day. How titrate from lower doses?

How could I restart my meds of fibromyalgia because of recurrence of symptoms. I used to take effexor&lyrica 75mg each/day. How titrate from lower doses?

Talk to doc.: It is best to speak to the prescribing physician! Lyrica (pregabalin) is often begun at 75 mg twice daily for fibromyalgia. Effexor is often titrated, at least the xr formulation, beginning at 37.5 for one week, then 75mg for one week before further titration depending on the target dose.

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I was diagnosed with fibromyalgia 1year ago. I took Effexor (venlafaxine) &lyrica 75mg a day. Two weeks ago I stopped taking medicine. I feel ok without it. Shall I do?

I was diagnosed with fibromyalgia 1year ago. I took Effexor (venlafaxine) &lyrica 75mg a day. Two weeks ago I stopped taking medicine. I feel ok without it. Shall I do?

Sit tight: If you are doing well and suffered no ill effects from the sudden stoppage of your meds then simply stay off of them and see how you do.

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How effective are lyrica (pregabalin) and tofranil for treating fibromyalgia?

Lyrica, (pregabalin) at times: Lyrica (pregabalin) may be beneficial, but I do not recommend tofranil. Restore sleep directly, reduce stress and consider electroprobe therapy or trigger point injections.

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Are there any approved treatments for fibromyalgia other than lyrica (pregabalin)?

Yes: I do not now if all of these are fda approved, but these are the medications used. Narcotics are never appropriate for fibro. Anti seizure meds like Lyrica (pregabalin) and Neurontin are used. An snri (effexor, cymbalta, or savella) is a mainstay of treatment. Physical activity is very important as well. Physical therapy can be helpful. Muscle relaxants might be used as well. Stay active!

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