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Doctor insights on: Lyrica Vs Savella For Fibromyalgia

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Tried numerous meds for fibro like lyrica, cymbalta, gabapentin, savella (milnacipran). None work, not fibromyalgia?

Tried numerous meds for fibro like lyrica, cymbalta, gabapentin, savella (milnacipran). None work, not fibromyalgia?

Fibromyalgia: Certainly the diagnosis may not be correct. Make sure you have had a Rheumatology work -up. Also it may be that the meds are just not working on you. ...Read more

Dr. Laurence Badgley
1,367 Doctors shared insights

Fibromyalgia (Definition)

Widespread pain and tenderness on palpation of specific muscle points, associated with variety of other symptoms that include fatigue, sleep disturbances, depression, ...Read more


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I have fibromyalgia but cannot take lyrica (pregabalin) what else is there?

I have fibromyalgia but cannot take lyrica (pregabalin) what else is there?

Antidepressants: I have found antidepressants most helpful. Particularly ones that are dual action like Effexor (venlafaxine) and Cymbalta also tricyclics like nortriptyline. These help with sense of wellbeing and fatigue. Also getting good sleep helps. I use trazodone 50mg for this part. ...Read more

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Aside from lyrica, (pregabalin) what medications is very helpful for fibromyalgia?

See details: Gagapentin (Neurontin), Cymbalta and Savella (milnacipran) are all potentially very effective. Topamax can also help. ...Read more

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I was diagnosed with fibromyalgia. I took affexor &lyrica for 1year but I stop medicine 3 mon ago since no pain. I ve some if I slept on hard mattress?

I was diagnosed with fibromyalgia. I took affexor &lyrica for 1year but I stop medicine 3 mon ago since no pain. I ve some if I slept on hard mattress?

Cured, at least for: Cured at least for present. If an activity causes pain, how important is that activity. If not important, avoidance is the best approach. ...Read more

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Is it preferable to continue having lyrica (pregabalin) for fibromyalgia? Now my pain is better. Should I replace it with another medicine after 4 months?

Is it preferable to continue having lyrica (pregabalin) for fibromyalgia? Now my pain is better. Should I replace it with another medicine after 4 months?

If it works, do it!: Fibromyalgia is generally forever. The cause of nerve hypersensitivity is unknown but fibromyalgia patients nerves do not function like other people's. If your pain is better on lyrica, (pregabalin) do not stop it unless you are having side effects. Temporary fluctuations in fibro pain occur but significant relief is to be treasured. If it ain't broke, don't "fix" it! ...Read more

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Should I continue takin effector & lyrica (pregabalin) 75 mg even that I am now better from fibromyalgia. What if I stop them now. Should I take them all of my life?

Should I continue takin effector & lyrica (pregabalin) 75 mg even that I am now better from fibromyalgia. What if I stop them now. Should I take them all of my life?

DEFINITELY!!!!!!: Yes you should continue the medications as the fibromyalgia is a chronic and lifelong condition. Your doses are very low so if these are effective I would definitely stick with it. ...Read more

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Do I have to take venlax75mg and lyrica (pregabalin) 75mg as well, each 1 pill a day if I am diagnosed with fibromyalgia. I feel so much better. Take all my life long?

Why use 2 meds?: You are on rather low dosing, and one or the other meds alone may do very well if dose is adjusted. Best to keep it simple, so have long discussion with your doctor and pick where efforts need to be focused. ...Read more

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I was diagnosed with fibromyalgia 1 year ago. I tookeffexor 75 &lyrica (pregabalin) 75 one pill a day& I felt better. Now I stopped takin lyrica (pregabalin) but I am feelin pain?

I was diagnosed with fibromyalgia 1 year ago. I tookeffexor 75 &lyrica (pregabalin) 75 one pill a day& I felt better. Now I stopped takin lyrica (pregabalin) but I am feelin pain?

Get back on Lyrica (pregabalin).: Lyrica (pregabalin) has been shown to be effective in treating fibromyalgia pain, but usual doses are 150 mg. Three times a day. Effexor is not shown to be effective but may improve your mood. Usual doses are around 300 mg. A day. It is pretty certain that 75 mg of Effexor will not be helpful for fibromyalgia pain. You must continue to take the Lyrica (pregabalin) to get benefit. ...Read more

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What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

What is better for fibromyalgia: cyclobenzaprine or lyrica (pregabalin)?

It depends: Every fibromyalgia patient is different and a medicine that works for one patient may not work for another. Cyclobenzaprine (flexeril) is a muscle relaxant that belongs to a class of drugs called the tricyclic antidepressants. Lyrica (pregabalin) is a seizure medicine that is also used to treat pain. While many patients benefit from these medicines, others don't tolerate them. You will have to try. ...Read more

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Is there a more effective medication than lyrica (pregabalin) for fibromyalgia pain?

It is individual: Lyrica (pregabalin) at night can help pain and improve sleep in some fm patients. However, Lyrica (pregabalin) does not help others and can cause side effects that limit effectiveness. Since all fm patients are different, individualized treatment is necessary. Find a provider who will work with you to find the most effective treatment for your fibromyalgia. ...Read more

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I hate lyrica's side effect but they r saying its the best for fibromyalgia is it true? Do I need to start using it or when should I start?

Not always: Lyrica (pregabalin) is only one option and there are several other meds which can very effective in the treatment of fibromyalgia. Many people do not tolerate lyrica (pregabalin). Get another opinion if your doctor will not discuss options with you. ...Read more

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I have a problem gaining weight on medications so is there anything else you can take for fibromyalgia other than Lyrica (pregabalin)? Thank you.

Yes there are: Unfortunately, weight gain is common with many of the oral medications used in the treatment of FBS. Medications in the same classes have differing degrees to which they contribute on an individual basis. Following is a list of different classes and examples of each: AED- Lyrica, (pregabalin) gabapentin, Topamax. TCA-Doxepin, amitriptyline. SNRI-Cymbalta, venlafaxine. Topamax often causes weight loss. ...Read more

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What do u mean by titrating meds from lower doses. I used to take effexor&lyrica 75mg one pill/day each coz of fibromyalgia. I used 2 stop meds 3months?

Talk to doc.: It is best to speak to the prescribing physician! Lyrica (pregabalin) is often begun at 75 mg twice daily for fibromyalgia. Effexor is often titrated, at least the xr formulation, beginning at 37.5 for one week, then 75mg for one week before further titration depending on the target dose. ...Read more

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How could I restart my meds of fibromyalgia because of recurrence of symptoms. I used to take effexor&lyrica 75mg each/day. How titrate from lower doses?

How could I restart my meds of fibromyalgia because of recurrence of symptoms. I used to take effexor&lyrica 75mg each/day. How titrate from lower doses?

Talk to doc.: It is best to speak to the prescribing physician! Lyrica (pregabalin) is often begun at 75 mg twice daily for fibromyalgia. Effexor is often titrated, at least the xr formulation, beginning at 37.5 for one week, then 75mg for one week before further titration depending on the target dose. ...Read more

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I was diagnosed with fibromyalgia 1year ago. I took Effexor (venlafaxine) &lyrica 75mg a day. Two weeks ago I stopped taking medicine. I feel ok without it. Shall I do?

I was diagnosed with fibromyalgia 1year ago. I took Effexor (venlafaxine) &lyrica 75mg a day. Two weeks ago I stopped taking medicine. I feel ok without it. Shall I do?

Sit tight: If you are doing well and suffered no ill effects from the sudden stoppage of your meds then simply stay off of them and see how you do. ...Read more

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How effective are lyrica (pregabalin) and tofranil for treating fibromyalgia?

Lyrica, (pregabalin) at times: Lyrica (pregabalin) may be beneficial, but I do not recommend tofranil. Restore sleep directly, reduce stress and consider electroprobe therapy or trigger point injections. ...Read more

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Are there any approved treatments for fibromyalgia other than lyrica (pregabalin)?

Yes: I do not now if all of these are fda approved, but these are the medications used. Narcotics are never appropriate for fibro. Anti seizure meds like Lyrica (pregabalin) and Neurontin are used. An snri (effexor, cymbalta, or savella) is a mainstay of treatment. Physical activity is very important as well. Physical therapy can be helpful. Muscle relaxants might be used as well. Stay active! ...Read more

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How effective are the medicines lyrica (pregabalin) and tofranil to treat fibromyalgia?

How effective are the medicines lyrica (pregabalin) and tofranil to treat fibromyalgia?

Lyrica (pregabalin) is effective: Lyrica is fairly effective. In my experience tofranil is not effective for the vast majority. Other options include gabapentin, Cymbalta and savella (milnacipran). ...Read more

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Is Lyrica (pregabalin) supposed to improve the aspect of pain or the sleep in Fibromyalgia patient?

Is Lyrica (pregabalin) supposed to improve the aspect of pain or the sleep in Fibromyalgia patient?

Both: The dose of Lyrica (pregabalin) is highly variable. The limiting factor for daytime use is its tendency to put people to sleep. I recommend taking enough during the day to alleviate the nerve pain, and enough at night to get a good night's sleep. Lyrica (pregabalin), like its cousin Gabapentin, is a great sleep-inducer. It's a natural sleep, unlike the benzos. I have one patient on 225 mg 3 times daily. Doing well. ...Read more

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Husband (32 yrs old) has fibromyalgia. He is not on any medication but has tried Lyrica and Cymbalta with bad side effects. What can we do?

Husband (32 yrs old) has fibromyalgia. He is not on any medication but has tried Lyrica and Cymbalta with bad side effects. What can we do?

One option: That can be discussed with his physician - is using acupuncture as an adjunctive treatment. I would not anticipate it to be a cure - but it can often be quite helpful. ...Read more

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I have fibromyalgia and now in quite intense pain (7/10). Lyrica seem doesn't work for now. What should I do to comforting myself? Worth to go to ER?

I have fibromyalgia and now in quite intense pain (7/10). Lyrica seem doesn't work for now. What should I do to comforting myself? Worth to go to ER?

Fibromylagia: In addition to conventional treatments by your doc please look into mind-body support. The work of John Sarno, MD, can be helpful. Please do a search on the net for his and related info. Peace and good health. ...Read more

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I am currently with a rhuematology specialist. He is running out of options to treat me. I'm currently on lyrica (pregabalin). But nothing helps my fibromyalgia?

I am currently with a rhuematology specialist. He is running out of options to treat me. I'm currently on lyrica (pregabalin). But nothing helps my fibromyalgia?

Get another opinion: I think it is a good time to get evaluated by an integrative medicine doctor or functional medicine doctor. There are so many things they are trained to evaluate and address that might be helpful. ...Read more

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Lately I feel that I don't have any sexual desire especially after I was diagnosed 6 months ago with having fibromyalgia. Iam taking lyrica (pregabalin) &effexor75?

Lately I feel that I don't have any sexual desire especially after I was diagnosed 6 months ago with having fibromyalgia. Iam taking lyrica (pregabalin) &effexor75?

Address now: This needs to be addressed as lack of sex drive can lead to frustration, depression, and loss of intimacy between couples. The lack may be a side-effect of one of the medications. If the lack is due to depression, that also would need to be addressed. The good news is that sex and exercise can be helpful is treating fibromyalgia. ...Read more

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I have fibromyalgia. I'm on lyrica (pregabalin) is there any new fibro meds on the market. I've had this disease for yrs now and so does my mom. Is there any new?

Yes: Consider savella (milnacipran) - new drug indicated for fibromyalgia with a different mechanism of action than lyrica. Discuss with prescribing physician to see if you are a candidate. ...Read more

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I've been on lyrica (pregabalin) for over a year now it's helped with fibromyalgia but my anxiety has got worse and migraines I can't even be around people now?

I've been on lyrica (pregabalin) for over a year now it's helped with fibromyalgia but my anxiety has got worse and migraines I can't even be around people now?

Further treatment: There is often a complex interaction between chronic pain, anxiety, depression and stress/triggers to migraine. In general, when on chronic meds for a chronic condition and things worsen, new symptoms develop, or symptoms remain at problematic levels, its time for re-assessment and consideration fo med adjustments or additional therapies. Psychotherapy often helps migraine and anxiety. ...Read more

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Do I have to take Effexor (venlafaxine) 75mg one pill a day &lyrica 75mg also one pill for my life long if I have fibromyalgia. Please help couldn't I have a baby.?

Do I have to take Effexor (venlafaxine) 75mg one pill a day &lyrica 75mg also one pill for my life long if I have fibromyalgia. Please help couldn't I have a baby.?

Integrative approach: There are many pharmacological options for fibromyalgia but an integrative approach will be better long term. Integrative approach will address your lifestyle, nutrition, sleep and stressors of life. Incorporating an active lifestyle combined with healthy diet, mind and body therapy and lowest possible doses of medication is the way to go. Of course you need to work closely with a rheumatologist. ...Read more