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Doctor insights on: Lyrica Insomnia

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On 10mg of zolpidem, 300mg lyrica, (pregabalin) 5mg of Valium at night all for anxiety and depression & insomnia . Bad combo? Feeling awful 20 days on :(

On 10mg of zolpidem, 300mg lyrica, (pregabalin) 5mg of Valium at night all for anxiety and depression & insomnia . Bad combo? Feeling awful 20 days on :(

Intense combination: I would talk to your doctor, you either need a lot of medicine or they may not be aware of how it is making you feel. However, it is important to let a medical professional determine the best way to make adjustments as the consequences of suddenly stopping or even changing could be seizures or a deterioration in your mental health. Stay safe! ...Read more

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Dr. Heidi Fowler
1,635 doctors shared insights

Insomnia (Definition)

Insomnia is a sleep disorder in which you cannot fall or stay asleep. It usually accompanies another sleep, medical, or psychiatric disorder, and can lead to memory impairment, mood changes, and increased risk of ...Read more


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What does lyrica (pregabalin) do?

Depends: Lyrica (pregabalin) was first introduced for seizures. However, it was found to have good activity in treatment neuropathic (nerve) pain. This type of pain is sometimes present in shingles and can last for a long time after the rash is gone. ...Read more

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Can lyrica (pregabalin) effect memory?

Yes but not always: Any medication that affects the central nervous system can definitely affect memory, and in that Lyrica (pregabalin) qualifies. If one was started on a high dose, there definitely could be memory complaints. Typically in my experience if the dose is started low and brought up very slowly memory problems are not seen. ...Read more

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Could i take lyrica (pregabalin) for "mood"?

Could i take lyrica (pregabalin) for "mood"?

Maybe: In controlled studies, about 5% of patients reported euphoria, but additional studies are needed to see if this will help mood. ...Read more

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Is tolerance an issue with Lyrica (pregabalin) ?

Unknown: No reports available in post marketing surveillance. It is not metabolized by the body and majority is excreted as intact drug. Thanks for trusting HealthTap! ...Read more

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Does Lyrica (pregabalin) calm overactive nerves ?

Lyrica (pregabalin) mechanism: Lyrica (pregabalin) blocks the neurons (receptors) which are in a hyper-excited status. These excited neurons only become the main cause of neurologic pain as experienced in central peripheral neuropathy. ...Read more

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Are there other options besides lyrica (pregabalin)?

Possibly: Lyrica (pregabalin) is used to treat pain and seizures. It may have some other off label uses as well. There are multiple medications that can be used to treat various types of pain, and multiple anticonvulsants. So, it really depends on the reason that it is given. If it is for nerve pain, then cymbalta, gabapentin, or tricyclic agents can be helpful. ...Read more