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Doctor insights on: Lympho Proliferative Disorder

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Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?

Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder.  Is this lymphoma?

Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more

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What is nonclonal mast cell activation disorder?

What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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What are post-transplant lymphoproliferative disorders?

What are post-transplant lymphoproliferative disorders?

Tumor from Infection: Immunosuppression lowers your immune defenses. One specific infection - the epstein barr virus can be a problem because it can stimulate 1 type of white blood cells, the b lymphocytes to grow uncontrollably. If this happens, treatment may include lowering (or stopping) immunosuppression, anti-viral medication and even chemotherapy. ...Read more

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Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder. What can it be? Is this serious? Treat?

Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder.  What can it be? Is this serious? Treat?

No: Even if it's a low grade lymphoma if it's not anywhere else there's a good chance it will never come back. They should be able to tell from special tests of your thymus. Good luck. ...Read more

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What causes myloproliferative disorder?

What causes myloproliferative disorder?

In most csses: There is no identifiable cause. It is acquired not genetic (inherited). ...Read more

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

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Endocervix exhibiting papillary hyperplasia with severe lymphoplasmatic infiltrate in the stroma.No transformation zone.what does this mean. Benign.

Endocervix exhibiting papillary hyperplasia with severe lymphoplasmatic infiltrate in the stroma.No transformation zone.what does this mean.
Benign.

Pathology report: You have to go over the details with your doc. The most important word was the last word that you typed which said that the lesion was BENIGN. Not malignant. That is the key but go over it with your doc. ...Read more

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Please interpret pericardium tissue mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.

Please interpret pericardium tissue 
 mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles.  Hemosiderin-laden macrophages.

Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more

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Adult male,bone marrow biopsy show Erythroid hyperplasia RBC borderline on high side,thrombocytopenia fluctuate, Splenomegaly,negative for infections.

Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.

CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more

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Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Yes: The presence of an autoimmune disorder points to dysregulation of the immune system and thus one is far more likely to have other autoimmune diseases . However, it is not directly linked to viral hepatitis or AML. ...Read more

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What type of leukemia involves immature white blood cells: lymphocytic or myeloid?

What type of leukemia involves immature white blood cells: lymphocytic or myeloid?

Leukemias: Acute leukemias are those with large numbers of immature cells that grow quickly. They can be either myeloid or lymphoid in lineage. Chronic leukemias have more mature cells, a longer course, but can also be myeloid or lymphoid. A hematologist/oncologist is generally the treating physician, and a hematopathologist is the one who give the specific syping. ...Read more

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What does myeloproliferative disorder with essential thrombocythemia mean?

What does  myeloproliferative disorder with essential thrombocythemia mean?

Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more

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Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Sometimes: Both ate classified as hodgkin but they can behave differetlny. Both are treated te same with chemo abvd regimen. Some new data suggest adding Rituxan (rituximab) if cd 20 positive in lymphocyte predominantly disease. ...Read more

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Help me interpret vulvar biopsy. Focal squamous atypia. Ki-67 shows mild increase cell proliferation focal vin can't be excluded. Lichen sclerosis?

Help me interpret vulvar biopsy. Focal squamous atypia. Ki-67 shows mild increase cell proliferation focal vin can't be excluded. Lichen sclerosis?

Nothing serious yet: This report suggests slightly abnormal changes (atypia & increased cell proliferation) which can be a reaction to irritation but there is no definitive evidence of precancerous change (VIN). In short there is nothing to worry about right now unless you are concerned and you'd like a second opinion ...Read more

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What are mylo proliferative neoplasms?

What are mylo proliferative neoplasms?

Blood disorder: It is a big group of blood neoplasm - where can be classified further into many different conditions - among of them will include - chronic myelogenous leukemia, polycythemia vera. Essential thrombocythemia, myelofibrosis, chronic eosinophilic leukemia, systemic mastocytosis etc- depending on which clones that are affected . Those conditions can transform into acute leukemia. ...Read more

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Wat is lymphoproliferative disorder actually lymphoma or leukemia i m confused?

The pathologist may: Diagnose a "lymphoproliferative disorder" to alert the clinicians to a need for more data to make the diagnosis of a lymphoma or leukemia. Ie a more generic term requiring more work-up or testing. ...Read more

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Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read more

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WHAT DOES BENIGN ENDOMETRIUM WITH A PROLIFERATIVE PATTERN, GLANDULAR BREAKDOWN AND DIFFUSE STROMAL BREAKDOWN - SCANT BENIGN ENDOCERVICAL TISSUE MEAN?

WHAT DOES BENIGN ENDOMETRIUM WITH A PROLIFERATIVE PATTERN, GLANDULAR BREAKDOWN AND DIFFUSE STROMAL BREAKDOWN - SCANT BENIGN ENDOCERVICAL TISSUE MEAN?

No worries!: Benign is normal or "non-cancerous". Proliferative just means the cells are in the phase where they are dividing which is normal during the estrogen part of the cycle. Endocervical tissue is just cells that came from inside the cervix - these were also benign! All good news! ...Read more