Top
20
Doctor insights on: Lyme Western Blot Ig G Positive 2 Bands Flagellin

Share
1

1
What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck!

Dr. Randy Baker
644 Doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


2

2
What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck!

3

3
When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

IgG: Upon appropriate stimulation, body begins to produce new specific IgG within about 2 weeks. A maximal response can be expected within 4 weeks. Can occur more quickly depending on dose of challenge/infection.

4

4
Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Not necessarily: IgM antibody means recent infection. IgG antibody usually means remote infection. You may not have the disease, just that you may have been infected at one time.

6

6
How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex

See 1 more doctor answer
7

7
15mts sick, itchy/painful, body sores. Had West. Blot for Lyme, 1active-58kd igG band. Know I need 5/10 for +, but what else causes 58kd to be active?

15mts sick, itchy/painful, body sores. Had West. Blot for Lyme, 1active-58kd igG band. Know I need 5/10 for +, but what else causes 58kd to be active?

Explanation: In your case 58kd mean nothing. It's call crossreactivity and can not proof Lyme D. with your rashes/sore you definitely need help. May be dermatologist will help.

9

9
Tested positive for Lyme disease IgM but my western blot test came back negtive?

Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated

10

10
I tested positive for Lyme disease. I was given the EIA (result 6.1), IgG (10 bands present) and IgM WB (3 bands) Does this mean I've had LD for a whi?

Yes: The presence of IgG usually indicates past infection which might have occurred months or even years ago. The presence of IgM indicates a current or recent infection.

11

11
What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

See details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease.

13

13
How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections?

How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections?

Lyme disease test: 18 M asks: How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections? ANS:Go to CDC site for details on accuracy of test. Best to discuss with your team as can be a complex issue.

14

14
Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:.

15

15
I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should I worry? Thanks

Not enough info: This test is not evidence of lyme but also not proof you don't have it! Ultimately lyme is a clinical diagnosis. 20-30% of those who have it never have a positive western blot. It's really important that the test include the 31 & 34 bands & most labs don't check it- igenex is the best lab for a thorough test. See a doc who uses igenex as that is someone able to make a proper diagnosis. See comment:.

See 1 more doctor answer
17

17
Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Probably have Lyme!: I don't know where to find such a list as I am not sure the causes of a false positive are known, but, esp. If the western blot did not include the 34 ; 39 bands I would not rely upon it; please do the igenex western blot, which is much more sensitive ; specific for lyme. Even if that is negative 20-30% with lyme can have a negative WB test. Other tests may be indicated. See http://bit. Ly/1aaqjgc.

19

19
2 years ago I had lyme ab screen mildly elevevated but western blot all non reactive. Now im testing pos for igm 23 and igm 41. What does this mean?

Interpret clinically: Lyme is known to be 'tricky'. The first set of tests I would ignore, since the Western blot was totally negative. In the second case, this could indicate an acute exposure since you've got 2 out of 3 IgM bands. You definitely need to talk to the doctor about these- since the lab work needs to be interpreted in the right clinical context. Sometimes lab tests come up as 'false positive'. See ID doc.

20

20
How accurate is Lyme disease western blot?

High disease area?: The Western Blot is the 2nd (after the ELISA) in a 2-step process. An individual in an area where Lyme disease is common & with high exposure to Lyme-disease carrying tick bite who has been bitten by an engorged tick is highly likely to have Lyme disease if these tests are positive. Without these risk factors, a positive test could be falsely positive.

See 1 more doctor answer