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Doctor insights on: Lyme Western Blot Ig G Positive 2 Bands Flagellin

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What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

Dr. Randy Baker
652 Doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

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When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

IgG: Upon appropriate stimulation, body begins to produce new specific IgG within about 2 weeks. A maximal response can be expected within 4 weeks. Can occur more quickly depending on dose of challenge/infection. ...Read more

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Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Not necessarily: IgM antibody means recent infection.
IgG antibody usually means remote infection. You may not have the disease, just that you may have been infected at one time. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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15mts sick, itchy/painful, body sores. Had West. Blot for Lyme, 1active-58kd igG band. Know I need 5/10 for +, but what else causes 58kd to be active?

Explanation: In your case 58kd mean nothing. It's call crossreactivity and can not proof Lyme D. with your rashes/sore you definitely need help. May be dermatologist will help. ...Read more

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

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I tested positive for Lyme disease. I was given the EIA (result 6.1), IgG (10 bands present) and IgM WB (3 bands) Does this mean I've had LD for a whi?

Yes: The presence of IgG usually indicates past infection which might have occurred months or even years ago. The presence of IgM indicates a current or recent infection. ...Read more

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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

See details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections?

How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections?

Lyme disease test: 18 M asks: How accurate is the cdc two tier testing for lyme disease after being infected for around 6-7 months? Also does the western blot detect co infections? ANS:Go to CDC site for details on accuracy of test. Best to discuss with your team as can be a complex issue. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should I worry? Thanks

Not enough info: This test is not evidence of lyme but also not proof you don't have it! Ultimately lyme is a clinical diagnosis. 20-30% of those who have it never have a positive western blot. It's really important that the test include the 31 & 34 bands & most labs don't check it- igenex is the best lab for a thorough test. See a doc who uses igenex as that is someone able to make a proper diagnosis. See comment:. ...Read more

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Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Probably have Lyme!: I don't know where to find such a list as I am not sure the causes of a false positive are known, but, esp. If the western blot did not include the 34 ; 39 bands I would not rely upon it; please do the igenex western blot, which is much more sensitive ; specific for lyme. Even if that is negative 20-30% with lyme can have a negative WB test. Other tests may be indicated. See http://bit. Ly/1aaqjgc. ...Read more

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2 years ago I had lyme ab screen mildly elevevated but western blot all non reactive. Now im testing pos for igm 23 and igm 41. What does this mean?

Interpret clinically: Lyme is known to be 'tricky'. The first set of tests I would ignore, since the Western blot was totally negative. In the second case, this could indicate an acute exposure since you've got 2 out of 3 IgM bands. You definitely need to talk to the doctor about these- since the lab work needs to be interpreted in the right clinical context. Sometimes lab tests come up as 'false positive'. See ID doc. ...Read more

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How accurate is Lyme disease western blot?

High disease area?: The Western Blot is the 2nd (after the ELISA) in a 2-step process. An individual in an area where Lyme disease is common & with high exposure to Lyme-disease carrying tick bite who has been bitten by an engorged tick is highly likely to have Lyme disease if these tests are positive. Without these risk factors, a positive test could be falsely positive. ...Read more

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Please tell me, is western blot test effective in diagnosing lyme?

Please tell me, is western blot test effective in diagnosing lyme?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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What to do if I did a Lyme disease test and it showed IgG p58 ab. Positive a can you explain what that means?

Nothing by itself: A single positive IgG band means nothing. Was the screen positive? How many other IgG and IgM bands were positive? You should discuss all of this with the doctor who ordered the test. ...Read more

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With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

Lyme blood test: In early Lyme Disease Elisa can be negative. No use testing Western Blot if Elisa is negative. Follow patient clinically and if symptoms of Lyme disease occur re-test Elisa. ...Read more

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From Minnesota but live in Madrid and got a western blot for Lyme back for: sensu strictu, afzelii, garinii, spielmanii. Is MN tick covered here?

Tick: Most common ticks in minnesota are the black legged tick, american dog tick, brown dog tick and the bat tick. Not sure if those are covered in Madrid. Better check with the Health Department there to determine for sure. ...Read more

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How long could the IgG in Lyme disease stay positive? Could it stay positive more than 5-10 years? I know the IgM ab convert to IgG just want an answer

How long could the IgG in Lyme disease stay positive? Could it stay positive more than 5-10 years? I know the IgM ab convert to IgG just want an answer

Yes, positive 20+ yrs: Research suggests igg antibodies can persist at least 20 years after infection. While igm antibodies appear first, unlike other infections they often persist ; are a good indicator of persistent infection. One may have chronic lyme with or without persistence of igg antibodies. Chronic lyme is difficult to fully eradicate ; no current test proves that it is no longer present in your body! ...Read more

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Please tell me, is western blot good in diagnosing Lyme disease?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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Igm is negative but IgG is positive for Lyme disease, what to do?

Old Infection: This most likely means you had an old infection with lyme disease. Our bodies make IgM early in an infection and IgG later. Even once the infection is gone there will be detectable IgG for quite some time. This is part of how our body remembers previous infections so we can fight them off better if we get them again. ...Read more

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Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly. ...Read more

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Is it possible to have a Lyme infection with a negative IgG but positive igm?

Is it possible to have a Lyme infection with a negative IgG but positive igm?

Yes: Igm is the immunoglobulin noted for coming out early in response to any illness, it fades over time while igg come out a bit later and stays up longer. If you have a positive IgM it indicates a early response, while igg would probably show up in a few months at which point the IgM would have declined. ...Read more

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Hello, I have the following symptoms listed above. I tested positive for IgG p66, IgG p41 And IGm P23. Do I have Lyme? Or a bacteria?

Lyme: Lyme is diagnosed from the following tests: ELISA, IFA, PCR, Western blot, culture or visualization. Western blot is positve and confirmatory for 5 of the following IgG antibodies to proteins 18, 23, 28, 30, 39, 41, 46, 58, 66, 93. You should have sympotms too. ...Read more

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I had a blood test (Western Blot), to check for Lyme Disease. The results look strange (0.45). This doesn't look like the result of any WB test I have?

Probably not Lyme: Your Western Blot would need to be above 5 for a conclusive confirmation of Lyme disease. Unless you also had known tick bite, low-grade fever, "erythema migrants", you probably had a viral illness that should resolve on its own. Do discuss this with your primary medical provider or specialist if symptoms persist. ...Read more

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My doctor is checking me for lyme. Is the western blot a reliable test to check for it?

My doctor is checking me for lyme. Is the western blot a reliable test to check for it?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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What is the difference in testing an IgG and IgM bands for Lyme versus multiple myeloma?

Different Diseases: Lyme and multiple myeloma are two very different diseases which are not likely to be confused for one another on a test like this. Igg and igm are two different types of proteins made by the immune system, and within each category you have thousands of different proteins in your body. For lyme, the test looks for a protein that proves your body has "seen" lyme organisms before. ...Read more

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Will the regular blood test and western blot test for Lyme disease rule out someone having it?

Will the regular blood test and western blot test for Lyme disease rule out someone having it?

It is a good test..: Enzyme-linked immunassay is a sreening test which if positive will be confirmed with a western-blot (=standard of testing). Although not absolutely 100%, a negative western blot is a good bet that there is no lyme at the time of testing. Early disease/infection may have negative test, thus recommended retesting in about 3 wks. Lyme dna testing is better, but more expensive. Consult doc. Good luck. ...Read more

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Lyme, Total AbTest/Reflex. Lyme IgG/IgM Ab < 0.91;Reference Interval:ISR 0.00-0.90; negative <0.91;equivocal 0.91-1.09;positive >1.09.Is above + or equi

Lyme, Total AbTest/Reflex. Lyme IgG/IgM Ab < 0.91;Reference Interval:ISR 0.00-0.90; negative <0.91;equivocal 0.91-1.09;positive >1.09.Is above + or equi

Negative: If a patient's lab test result is <0.91, and the lab says the reference range for NEGATIVE is <0.91, then the test result is NEGATIVE. Of course, numbers are just numbers, so the doctor needs to see the numbers in the context of the whole patient in order to make sensible and accurate conclusions from the numbers. ...Read more

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Is an IgG positive Lyme test a risk?

Lyme disease: Lyme diagnosis is made on one's history, exposure to tick that carry lyme disease in the setting of typical signs and symptoms. If a doctor confirms the typical bulls-eye rash lab testing is not required for diagnosis. Igb g positive indicates potential infection with lyme disease and may be present even after the infection has resolved and should be utilized in conjunction with clinical featue. ...Read more

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Are Lyme tests Elisa & western blot actually unreliable half the time like holistic/naturopath doctors or LLMD's say?

Not true: Naturopaths spend a great deal of time and effort promoting themselves by debunking conventional medicine. But who do you think they go to when they are sick? The tests you mention are mostly reliable but there is a small margin of error for any tests. To say these are unreliable at the 50% level is marketing and untrue. ...Read more