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Doctor insights on: Lyme Western Blot Ig G Bands 18 30

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

Dr. Randy Baker
639 doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Not necessarily: IgM antibody means recent infection. IgG antibody usually means remote infection. You may not have the disease, just that you may have been infected at one time. ...Read more

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

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When are lyme igg antibodies most present in the body.if I was exposed around 7 months ago would the igg western blot be positive?

When are lyme igg antibodies most present in the body.if I was exposed around 7 months ago would the igg western blot be positive?

IgG: Upon appropriate stimulation, body begins to produce new specific IgG within about 2 weeks. A maximal response can be expected within 4 weeks. Can occur more quickly depending on dose of challenge/infection. ...Read more

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15mts sick, itchy/painful, body sores.Had West.Blot for Lyme, 1active-58kd igG band. Know I need 5/10 for +, but what else causes 58kd to be active?

15mts sick, itchy/painful, body sores.Had West.Blot for Lyme, 1active-58kd igG band. Know I need 5/10 for +, but what else causes 58kd to be active?

Explanation : In your case 58kd mean nothing. It's call crossreactivity and can not proof Lyme D. with your rashes/sore you definitely need help. May be dermatologist will help. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease?  What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

see details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly. ...Read more