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Doctor insights on: Lyme Western Block False Negative

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Dr. Randy Baker
652 doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

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Can an HIV antibody screening test be positive but the western blot negative?

Can an HIV antibody screening test be positive but the western blot negative?

Yes: There are 2 reasons for this kind of result: (1) a false positive, or (2) early infection before seroconversion. In someone at low risk for HIV without symptoms, another negative WB in 1 month means there's no infection. In someone at risk or with symptoms of acute infection, a viral load can be helpful. The new 4th generation antigen/antibody tests will eliminate this problem. ...Read more

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Plz interpret. ANA via ELISA 74 units, strong positive (negative via IFA) Anti-Cardiolipin IgG 22 CU, moderate positive others neg. symptom fatigue?

Plz interpret.  
ANA via ELISA 74 units, strong positive (negative via IFA)
Anti-Cardiolipin IgG 22 CU, moderate positive 
others neg.
symptom fatigue?

Short answer is : Needing more info on labs and clinical symptoms. ANA positive is sensitive for possible autoimmune disease.but not very specific. Every lab on your ENA panel is important esp they are moderate positive and they all mean something different. Lab is never enough for diagnosis esp rheumatic condition. It is important for you to find a rheumatologist for thorough history and physical exam. ...Read more

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Tested false positive ELISA HIV test last month. Negative ifa and western blot and naat. 2 negative oraquick all 1 1/2 year post exposure. Hiv?

Negative: If nat was negative at 6 months after exposure you not likely to have hiv. Given all the negative test results, you should not worry about the one apparently false positive. ...Read more

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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

see details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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Does the western blot trump the elisa? Tested positive via ELISA IgG for hsv2,but later tested negative via western blot. No symptoms. Do I have hsv2?

Does the western blot trump the elisa? Tested positive via ELISA IgG for hsv2,but later tested negative via western blot. No symptoms. Do I have hsv2?

Western blot more: specific, ELISA more sensitive. One positive ELISA and one negative Western blot says that you do not have enough antibodies to HSV 2 for confirmation of diagnosis. It may be prudent to repeat the tests in 3-4 months to make sure that negative Western blot was not due to incomplete/early immune response. ...Read more

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2009- ELISA HIV test- positive, western blot- neg. 2010-oraquick negative. 2014- elisa-indeterminate wb- neg. Low risk for hiv. Could I have lupus?

Not a test for lupus: The HIV test is not a test for lupus. What's clear is that you don't have hiv. You'll never know why your elisa was positive and then indeterminate, and it's not worth investigating. False positive elisas are not uncommon; that's why they have to be confirmed with western blot. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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Positive HIV screener test at blood donation... Negative IFA and Negative NAT... False positive?

Positive HIV screener test at blood donation... Negative IFA and Negative NAT... False positive?

Yes: The initial screening test for HIV is very sensitive, but not very specific. The back up screening tests are much more specific for HIV. ...Read more

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What can cause false positive ELISA HIV test? 2 confirmatories neg and viral load neg. No bands detected.

Many things: An elisa test for HIV is very sensitive which basically means it is a good test for ruling out HIV and is only reliable when negative. A positive elisa test does not mean someone has HIV and is frequently called a "false positive" there are many causes of a false positive which include liver disease, blood tranfusions, infections, autoimmune disease and dumb luck! ...Read more

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Are false positive HIV tests rare?

Are false positive HIV tests rare?

HIV testing: This depends upon the test employed. They are generally both sensitive and specific but false positive results do occur. This question can be overcome with further testing, the most specific being PCR for HIV RNA. You should be seen by an expert in the management of HIV disease. ...Read more

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Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Cannot diagnose: Although these lab values are interesting, taken out of the context of your symptoms and findings on physical examination, plus further testing there is no way in which to diagnose over the internet. See a rheumatologist and get appropriately assessed. ...Read more

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What causes false positive HCV antibody test results?

What causes false positive HCV antibody test results?

Misinformed?: Who told you that your hep c test was false? If you have no viral load that means you cleared an infection. Are you sure you are getting the right advice? ...Read more

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False positive ELISA HIV test.Neg western blot, neg ifa &naat.I've had 2 neg oraquick home test. Could i be an elite controller? Or already have aids?

False positive ELISA HIV test.Neg western blot, neg ifa &naat.I've had 2 neg oraquick home test. Could i be an elite controller? Or already have aids?

No: Western blot is fairly definitive. You have 2 negative home tests and you are quite stressed about your testing: her's an idea: use condoms: protect yourself (and others) at all times. ...Read more