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Doctor insights on: Lyme Disease Inconclusive Test Results

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Dr. Randy Baker
656 Doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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Can you have Lyme disease and still have a negative test result on the western blot test?

Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly. ...Read more

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I had a blood test (Western Blot), to check for Lyme Disease. The results look strange (0.45). This doesn't look like the result of any WB test I have?

I had a blood test (Western Blot), to check for Lyme Disease. The results look strange (0.45). This doesn't look like the result of any WB test I have?

Probably not Lyme: Your Western Blot would need to be above 5 for a conclusive confirmation of Lyme disease. Unless you also had known tick bite, low-grade fever, "erythema migrants", you probably had a viral illness that should resolve on its own. Do discuss this with your primary medical provider or specialist if symptoms persist. ...Read more

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Lyme disease ab plus reflex to igg, igm-wb blood test done today. How long for results and how accurate are they?

Lyme disease ab plus reflex to igg, igm-wb blood test done today. How long for results and how accurate are they?

About a week: The regular lyme test is specific but not very sensitive. There can be many reasons for a false positive result. If it is positive on the screening test it is then sent for the more sensitive western blot test. If the igm test is positive it could represent a recent exposure to lyme disease if the igg is positive it indicates a more distant orast exposure. If the igm is positive you should be eval. ...Read more

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Could I test negative for Lyme disease but actually had it?

Only: If you recently been bitten by the tick, or where profoundly immunosuppressed. ...Read more

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Low cd57 and Lyme disease? Are these tests some method of detecting Lyme disease?

Contorversial: Cd57 testing is a controversial way of trying to determine if someone has lyme disease. It is not widely accepted as accurate and most clinicians do not test for it. ...Read more

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What is the single best test for Lyme disease?

What is the single best test for Lyme disease?

Possibly new culture: There are many tests for lyme, but none are totally reliable. The elisa test is positive in about half of those infected. The western blot test is positive in ~70% of cases, but most labs don't do a thorough enough version- I recommend igenex labs. Pcr tests are positive only ~20% of the time. A new test, a culture by advanced laboratory services may detect lyme in >80% of cases so may be best. ...Read more

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What is the most reliable test for Lyme disease?

Western blot: The western blot test is the more sensitive test of blood. Other fluids, like joint fluid can be tested by a procedure called PCR to better determine presence of Lyme ...Read more

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Is there a Lyme disease test?

Is there a Lyme disease test?

Yes: There are blood and cerbrospinal fluid tests that can be done to aid in the diagnosis of lyme disease. They must be interpreted carefully by experienced clinicians. ...Read more

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What test do I need to check for Lyme disease?

What test do I need to check for Lyme disease?

Blood test and exam: Examination, history and routine lyme screening ELISA test is recommended for diagnosis. Rash consistent with lyme is classic for diagnosis. ...Read more

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Is it possible for a negative Lyme disease test to be wrong? I read online it's correct maybe 60% of the time....

About lab tests...: If a person does a lab test that is correct 60% of the time, that may mean the test result is incorrect 40% of the time. If a patient's symptoms and history are suggestive of Lyme disease, a Lyme disease positive test result will be more likely to be a true positive. If symptoms and history are NOT suggestive of Lyme disease, a positive test result has higher chances of being a false positive. ...Read more

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Any special test for Lyme disease?

Any special test for Lyme disease?

ELISA/West blot.: The 2 main best tests, early or late, are elisa and western blot. Elisa or serology is used for screening for an antibody response to the b. Burgdorferi spirochete responsible for the disease, while the western blot is a specific test that makes sure the positive response is not a false positive, or a reaction to something else. Pcr, or polymerase chain reaction is another possible test. ...Read more

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What are blood tests for Lyme disease?

What are blood tests for Lyme disease?

ELISA/West blot.: The 2 main tests are elisa and western blot. Elisa or serology is used for screening to see if there is an antibody response to the b. Burgdorferi spirochete responsible for the disease, while the western blot is a specific test that makes sure the positive response is to this and not a false positive, or a reaction to something else. Pcr, or polymerase chain reaction is another possible test. ...Read more

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What's a reliable test for Lyme disease?

Western Blot Analysi: A western plot analysis which looks at at least 5 and sometimes 7 individual preciptins. You must have three positive for a definitive dx. ...Read more

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What is the diagnostic test for Lyme disease?

What is the diagnostic test for Lyme disease?

Western blot & Elisa: The diagnosis is based on the history and physical and early the rash erythema chronicum migrans and immediate therapy is indicated The test your physician can do is to test for Borrelia Burgdorferi. You will have the Elisa test to screen and then the western blot tests for antigens from the Borrelia Burdorferi. Sometimes a PCR test can be used. You can discuss this with your physician. ...Read more

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What is the diagnostic test for Lyme disease?

What is the diagnostic test for Lyme disease?

First: An ELISA blood test, if pos then Western Blood Test looking for at least 5 pos. ...Read more

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How much would it take to get test for Lyme disease?

How much would it take to get test for Lyme disease?

Depends on the test: There are many tests for lyme- elisa, western blot, ifa, pcr, cultures. Testing can be expensive. If you have limited resources I advise the igg & IgM western blot from igenex- their test is more thorough & sensitive than other labs. It costs about $200.
No single test totally proves or disproves if one has lyme- it is a clinical diagnosis, but the right tests are very helpful. ...Read more

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Is it true that Lyme disease is extremely hard to test for?

Yes: Top Lyme literate doctors, like Dr. Deitrich Klinghardt uses energy resonance testing to diagnose Lyme. Very accurate Routine blood testing is inadequate. According to Harvard U Lyme literate doctor Joathan Edlow. ...Read more

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Could I have Lyme disease? Not posible its recent. Borrelia Oct 14 IgM = 1.00 (1-1.5 inconclusive), Jan 15 IgM = 1.53 (1.5+pos) IgG = 0.16 (<1.00neg)

See details: The lab results sre unimpressive. I strongly doubt Lyme disease based on your lab results. Without your symptoms and results of a Western blot it is impossible to answer. I ...Read more

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What is a Lyme disease antibody reflex to wb test?

What is a Lyme disease antibody reflex to wb test?

See details: It is a test for lyme disease. A positive screen alone is not diagnostic. It needs to be confirmed by the western blot test which actually tests for specific antibodies related to the lyme organism. ...Read more

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Can you have Lyme disease if the blood test comes back negative?

No: Others may argue this point but I firmly believe a positive lyme screen and western blot is essential for the diagnosis. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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I have to take a ELISA test today for Lyme disease but I was just wondering how does ELISA test work?

Sandwich assay...yum: Elisa = enzyme-linked immuno sorbent assay. Done by adding serum from a subject to a plate w/antibody against the infection you're testing for on its surface. The antigen (or protein) from the infection binds to the antibody on the plate. Then another antibody to the infection w/color signal chemical attached is added on top and binds to the antigen. If infection is there color can be measured. ...Read more

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What to do if I have to take a ELISA test today for Lyme disease but I was just wondering. 1. how does ELISA test work?

Just show up: You just show up and have your blood drawn. If your Lyme screening test is positive, they will automatically do more specific antibody testing on your blood to determine if you have active Lyme disease. ...Read more

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How accurate are Lyme disease tests? I find varying opinions online, but it sounds like it can be easily missed in tests?

Accurate but: The test result must be interpreted along with clinical findings. Thus one cannot be considered as having Lyme Disease simply because of a positive test. I do know that some practitioners are over-diagnosing Lyme disease as the cause for many ailments including Parkinson's disease etc without any proven scientific evidence. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should I worry? Thanks

Not enough info: This test is not evidence of lyme but also not proof you don't have it! Ultimately lyme is a clinical diagnosis. 20-30% of those who have it never have a positive western blot. It's really important that the test include the 31 & 34 bands & most labs don't check it- igenex is the best lab for a thorough test. See a doc who uses igenex as that is someone able to make a proper diagnosis. See comment:. ...Read more

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What does one do if they got treatment for Lyme disease, but still getting same sympthoms and test now coming up negative? Test was wrong 2x last time

Lyme dz: These may not be Lyme symptoms. Check with doc. Alternatively, Lyme produces immune responses that linger, become chronic. Joints and other tissues can be affected. Requires careful interpretation by doc who sees you frequently. ...Read more

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What is the best Lyme disease test? I've had the basic blood test done, came back negative, but is there a more thorough test to rule it out?

What is the best Lyme disease test? I've had the basic blood test done, came back negative, but is there a more thorough test to rule it out?

Thorough WesternBlot: The screen many doctors use, the elisa, only detects about half of those with lyme. A much more sensitive and specific test is the western blot, but I strongly advise doing this through ignenex in palo alto, a specialty lab, as the test offered by most other labs does not include tests for antibodies to the 31 & 34 kda antigens, which are the most specific antigens for lyme! Please see my comment. ...Read more

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If I have a negative lyme disease test, but antibiotics appear to be addressing my symptoms, is there any way to tell what caused the symptoms?

If I have a negative lyme disease test, but antibiotics appear to be addressing my symptoms, is there any way to tell what caused the symptoms?

Not a clue: When you submit a question, you must provide enough background information for site docs to review. You provide no info beyond a negative test result. No history, no exam findings, no initial problem. This is not a chat room, so any question must be complete, We do not have access to any previous question or data you upload. ...Read more

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I got bitten by a tick and I am o an antibiotic now. Is there a test that would tell me that I did not get Lyme disease?

See details: Once you start antibiotic therapy you are essentially being treated to prevent lyme disease from developing. This also will usually prevent you from developing a positive lyme test. Do not worry. ...Read more

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

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What to do if I did a Lyme disease test and it showed IgG p58 ab. Positive a can you explain what that means?

Nothing by itself: A single positive IgG band means nothing. Was the screen positive? How many other IgG and IgM bands were positive? You should discuss all of this with the doctor who ordered the test. ...Read more