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Doctor insights on: Lyme Antibody Negative Ig G Positive

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Dr. Thomas Knecht Dr. Knecht
Internal Medicine - Endocrinology
27 years in practice
UC San Diego School of Medicine
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What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck!

Dr. Randy Baker
644 Doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


Dr. Corey Clay Dr. Clay
Internal Medicine - Allergy & Immunology
6 years in practice
The Ohio State University College of Medicine
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When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

When are lyme igg antibodies most present in the body. If I was exposed around 7 months ago would the igg western blot be positive?

IgG: Upon appropriate stimulation, body begins to produce new specific IgG within about 2 weeks. A maximal response can be expected within 4 weeks. Can occur more quickly depending on dose of challenge/infection.

Dr. John Goldman Dr. Goldman
Internal Medicine - Rheumatology
51 years in practice
University of Cincinnati College of Medicine
4
Dr. Bruce Rothschild Dr. Rothschild
Internal Medicine - Rheumatology
37 years in practice
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School
5
Dr. Stephen Scholand Dr. Scholand
Internal Medicine - Infectious Disease
19 years in practice
George Washington University Medical School
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If I am on antibiotic and an acne gel, can that affect or cause false results on a toxoplasma IgG test or a Lyme IgG test?

If I am on antibiotic and an acne gel, can that affect or cause false results on a toxoplasma IgG test or a Lyme IgG test?

No, meds won't do it: Ninety percent of us have been exposed to Toxoplasma, so it's no surprise your IgG test for that is positive. No worries there. With Lyme IgGs it depends on 'what bands' may or may not be positive. You would need at least 5 bands on the IgG test to be considered a positive, but then that needs to be interpreted in the right clinical context. Ur meds aren't at fault. Good to check back with ur doc.

Dr. Michael Rupp Dr. Rupp
Internal Medicine - Allergy & Immunology
17 years in practice
Keck School of Medicine of University of Southern California
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Igm is negative but IgG is positive for Lyme disease, what to do?

Old Infection: This most likely means you had an old infection with lyme disease. Our bodies make IgM early in an infection and IgG later. Even once the infection is gone there will be detectable IgG for quite some time. This is part of how our body remembers previous infections so we can fight them off better if we get them again.

Dr. James Ferguson Dr. Ferguson
Pediatrics
42 years in practice
University of Texas Medical Branch School of Medicine
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Is it possible to have a Lyme infection with a negative IgG but positive igm?

Is it possible to have a Lyme infection with a negative IgG but positive igm?

Yes: Igm is the immunoglobulin noted for coming out early in response to any illness, it fades over time while igg come out a bit later and stays up longer. If you have a positive IgM it indicates a early response, while igg would probably show up in a few months at which point the IgM would have declined.

Dr. Robert Kwok Dr. Kwok
Pediatrics
29 years in practice
Baylor College of Medicine
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Lyme, Total AbTest/Reflex. Lyme IgG/IgM Ab < 0.91;Reference Interval:ISR 0.00-0.90; negative <0.91;equivocal 0.91-1.09;positive >1.09.Is above + or equi

Lyme, Total AbTest/Reflex. Lyme IgG/IgM Ab < 0.91;Reference Interval:ISR 0.00-0.90; negative <0.91;equivocal 0.91-1.09;positive >1.09.Is above + or equi

Negative: If a patient's lab test result is <0.91, and the lab says the reference range for NEGATIVE is <0.91, then the test result is NEGATIVE. Of course, numbers are just numbers, so the doctor needs to see the numbers in the context of the whole patient in order to make sensible and accurate conclusions from the numbers.

Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
10
Dr. Ramachandran Srinivasan Dr. Srinivasan
Internal Medicine - Rheumatology
48 years in practice
Andhra University, Andhra Medical College
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Is an IgG positive Lyme test a risk?

Lyme disease: Lyme diagnosis is made on one's history, exposure to tick that carry lyme disease in the setting of typical signs and symptoms. If a doctor confirms the typical bulls-eye rash lab testing is not required for diagnosis. Igb g positive indicates potential infection with lyme disease and may be present even after the infection has resolved and should be utilized in conjunction with clinical featue.

Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
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I got a Lyme disease test done.& IgG 66 came positive out of the other 10 bands. What does this mean? Do I have Lyme or had it? Should I worry? Thanks

Not enough info: This test is not evidence of lyme but also not proof you don't have it! Ultimately lyme is a clinical diagnosis. 20-30% of those who have it never have a positive western blot. It's really important that the test include the 31 & 34 bands & most labs don't check it- igenex is the best lab for a thorough test. See a doc who uses igenex as that is someone able to make a proper diagnosis. See comment:.

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Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
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What to do if I did a Lyme disease test and it showed IgG p58 ab. Positive a can you explain what that means?

Nothing by itself: A single positive IgG band means nothing. Was the screen positive? How many other IgG and IgM bands were positive? You should discuss all of this with the doctor who ordered the test.

Dr. Eric Weisman Dr. Weisman
Neurology
32 years in practice
St. George's University School of Medicine
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I got a Lyme WB and IGG p39 and p41 present. Other IGG and all IGM negative. Some symptoms present (neuro, dysautonomia, cardio). Do I have Lyme?

I got a Lyme WB and IGG p39 and p41 present. Other IGG and all IGM negative. Some symptoms present (neuro, dysautonomia, cardio). Do I have Lyme?

Not likely: A positive test would be 6 or more out of 10 markers. P41 is commonly positive in those without Lymes

Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
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How long could the IgG in Lyme disease stay positive? Could it stay positive more than 5-10 years? I know the IgM ab convert to IgG just want an answer

How long could the IgG in Lyme disease stay positive? Could it stay positive more than 5-10 years? I know the IgM ab convert to IgG just want an answer

Yes, positive 20+ yrs: Research suggests igg antibodies can persist at least 20 years after infection. While igm antibodies appear first, unlike other infections they often persist ; are a good indicator of persistent infection. One may have chronic lyme with or without persistence of igg antibodies. Chronic lyme is difficult to fully eradicate ; no current test proves that it is no longer present in your body!

Dr. Randy Baker Dr. Baker
Holistic Medicine
36 years in practice
University of Michigan Medical School
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Lyme IgG/IgM Ab result is <0.91."Reference interval:ISR 0.00-0.90, reference interval for neg is<0.91." Is test tesult neg with above 2 refer, interval

Neg;might have Lyme: This is a negative result but does not mean you don't have Lyme. The type of test you had will be negative in at least half of those who have Lyme. I advise you get a Western Blot from IgeneX but even that may be negative in 20% of those with Lyme. See http://www. Betterhealthguy. Com/lyme/testing for more info.

Dr. John Chiu Dr. Chiu
Internal Medicine - Allergy & Immunology
53 years in practice
University of Vermont College of Medicine
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I tested positive for Lyme disease. I was given the EIA (result 6.1), IgG (10 bands present) and IgM WB (3 bands) Does this mean I've had LD for a whi?

I tested positive for Lyme disease. I was given the EIA (result 6.1), IgG (10 bands present) and IgM WB (3 bands) Does this mean I've had LD for a whi?

Yes: The presence of IgG usually indicates past infection which might have occurred months or even years ago. The presence of IgM indicates a current or recent infection.

Dr. Thomas Knecht Dr. Knecht
Internal Medicine - Endocrinology
27 years in practice
UC San Diego School of Medicine
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What is difference between IgM and IgG for western blot for lyme. Positive for IgM but not IgG, what does that mean? Tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck!

Dr. Stuart Hickerson Dr. Hickerson
Family Medicine
28 years in practice
University of Illinois College of Medicine
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Hello, I have the following symptoms listed above. I tested positive for IgG p66, IgG p41 And IGm P23. Do I have Lyme? Or a bacteria?

Hello, I have the following symptoms listed above. I tested positive for IgG p66, IgG p41 And IGm P23. Do I have Lyme? Or a bacteria?

Lyme: Lyme is diagnosed from the following tests: ELISA, IFA, PCR, Western blot, culture or visualization. Western blot is positve and confirmatory for 5 of the following IgG antibodies to proteins 18, 23, 28, 30, 39, 41, 46, 58, 66, 93. You should have sympotms too.

Dr. Sandra Lora Cremers Dr. Cremers
Ophthalmology
21 years in practice
Warren Alpert Medical School of Brown University
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I've read that most tests for Lyme are not accurate and give false negatives. Doc ordered Lyme Ab Igm/Igg. So will the results of it even be helpful?

I've read that most tests for Lyme are not accurate and give false negatives. Doc ordered Lyme Ab Igm/Igg. So will the results of it even be helpful?

Lyme: Lyme disease is a controversial issue most blood tests are accurate but there is a high false positive and negative rate. See Eyedoc2020.blogspot. Com

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more