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Doctor insights on: Lyme A False Positive Elisa Test Result

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Dr. Randy Baker
647 Doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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Can you have Lyme disease and still have a negative test result on the western blot test?

Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly.

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I have to take a ELISA test today for Lyme disease but I was just wondering how does ELISA test work?

I have to take a ELISA test today for Lyme disease but I was just wondering how does ELISA test work?

Sandwich assay...yum: Elisa = enzyme-linked immuno sorbent assay. Done by adding serum from a subject to a plate w/antibody against the infection you're testing for on its surface. The antigen (or protein) from the infection binds to the antibody on the plate. Then another antibody to the infection w/color signal chemical attached is added on top and binds to the antigen. If infection is there color can be measured.

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What to do if I have to take a ELISA test today for Lyme disease but I was just wondering. 1. how does ELISA test work?

What to do if I have to take a ELISA test today for Lyme disease but I was just wondering. 1. how does ELISA test work?

Just show up: You just show up and have your blood drawn. If your Lyme screening test is positive, they will automatically do more specific antibody testing on your blood to determine if you have active Lyme disease.

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Are Lyme tests Elisa & western blot actually unreliable half the time like holistic/naturopath doctors or LLMD's say?

Are Lyme tests Elisa & western blot actually unreliable half the time like holistic/naturopath doctors or LLMD's say?

Not true: Naturopaths spend a great deal of time and effort promoting themselves by debunking conventional medicine. But who do you think they go to when they are sick? The tests you mention are mostly reliable but there is a small margin of error for any tests. To say these are unreliable at the 50% level is marketing and untrue.

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Western blot-positive band 41, ELISA-positive. LLMD says I have Lyme, MD is skeptical. Ok so do I start Lyme treatment or not? I'm torn.....

NO 41 K is only one: 41 K is very common - you need more band than that. Look at your lab report and discuss it with your physician. Some reports require 3 or 4 bands.

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How long do antibodies remain detectable in the blood? I had a clear ELISA for Lyme disease after recurring lightheadedness and brain fog after a possible bite when hiking in the uk but the test was a good 10 months later -would it still be reliable?

How long do antibodies remain detectable in the blood? I had a clear ELISA for Lyme disease after recurring lightheadedness and brain fog after a possible bite when hiking in the uk but the test was a good 10 months later -would it still be reliable?

Some antibodies: Last for years and some others (such as chicken pox) last a lifetime.....It is VERY unlikely that you had a Lyme exposure if the tests are negative in 10 months!

Hope this is helpful
Dr Z

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I had a perfect bulls eye rash on my upper arm 7 years ago, can a doctor treat you for Lyme without the testing? I had an ELISA test 4yrs ago. Neg.

I had a perfect bulls eye rash on my upper arm 7 years ago, can a doctor treat you for Lyme without the testing? I had an ELISA test 4yrs ago. Neg.

Other possible cause: A "perfect bullseye rash" is highly likely to be lyme's. But bullseye rashes can be a symptom of another condition, like erythema multiforme. Check it out: <a href="http://en. Wikipedia. Org/wiki/erythema_multiforme" rel="nofollow" target="_blank">http://en. Wikipedia. Org/wiki/erythema_multiforme</a>. Good luck.

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Can dawson fingers brain lesions present in lymes disease? I'm hoping I have lymes and not ms. My igenex test was positive and ELISA test CDC neg.

Possibly: Dawson's fingers which appear on imaging is more consistent with demyelinating disease such as multiple sclerosis and not infection such as lyme. You need to have a more detailed evaluation and may need additional studies to make a definitive diagnosis.

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With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

Lyme blood test: In early Lyme Disease Elisa can be negative. No use testing Western Blot if Elisa is negative. Follow patient clinically and if symptoms of Lyme disease occur re-test Elisa.

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42 female, acute onset swelling/pain leg, knee, ankle, feet, wrist. Fatigue. Eosinophil level 760. bit by tick 8 weeks ago. ELISA neg. For Lyme disease.

Must treat: This is very suspicious for Lyme. About 30% will never test positive for Lyme. You need a course of antibiotics ASAP. Lyme must be treated quickly, or else it becomes chronic and is much harder to treat.

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Can you get ELISA HIV antibody test result within an 1 hour from hospital?

Yes.: The test can technically be done in less than an hour. However, time taken for blood draw, transportation to the lab and if the tests are batched, will all add time and it may take a day or so to get the results.

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What could cause a false positive/negative result in an ELISA immune system test?

Need more details.: You will need to tell us the type of tests involving the ELISA technique. Either false positive or false negative may mean a lab error, borderline values, or test results not corresponding with the disease condition. Each test has its own pluses and minuses.

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Does a false positive ELISA HIV test mean someone has a autoimmune disease? Or could it be anything? Do people find out why they get these results?

Does a false positive ELISA HIV test mean someone has a autoimmune disease? Or could it be anything? Do people find out why they get these results?

No: While false positives can be from nothing specific, they can be related to infections from other viruses that may make similar antibodies that can react with elisas, but this has to be confirmed with western blot. I personally would ask for two confirmations as it can take up to six weeks for viral levels to be high enough to be sure with the test. Check with infectious disease doc to be safe.

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My pap test result was a "false positive." what does this mean?

My pap test result was a "false positive." what does this mean?

Abnormal: To say that a test is a false positive, signifies that your pap test was normal and incorrectly reported as abnormal. You should see your physician for clarification.

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How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

Lupus biopsy: Biopsy of lupus has a number of features that lead to diagnosis: a thickened basement membrane, vacuolar alteration of basal keratinocytes and superficial and deep inflammatory infiltrate. Lupus has a number of different forms in the skin and there are times when it is not easy to differentiate it from other types of skin inflammation. There are other tests to support diagnosis.

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Elisa (Definition)

Enzyme-linked immunosorbent assay (elisa) is a test that uses antibodies and color change ...Read more