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Doctor insights on: Lupus Without Positive Ana

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Positive ana positive rnp low positive ccp positive dsdna can you tell me if this means lupus or mctd?

Positive ana positive rnp low positive ccp positive dsdna can you tell me if this means lupus or mctd?

?: depends on the clinical picture as well, results point towards auto immune disorder, but need to be put in clinical context and follow up to commit to a diagnosis ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about it?: Up to a quarter of women your age have an ANA (immunofluorescent antibody) at a low titer like yours with a speckled pattern. If there's a question of whether you have lupus or one of its relatives, it's a piece of information to note and file for future reference. A negative ANA would rule several things out. Your result proves nothing positive. Best wishes. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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Will a positive ANA necessairly mean lupus?

No: A positive ANA alone does not make one have lupus. Other criteria must be met to be labeled with lupus. ANA can often be false positives. ...Read more

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ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

Pos auto ab tests: You are describing positive tests for auto antibodies. The differential diagnosis can be extensive. I am assuming a rheumatologist has ordered these tests? You need f/u with them to educate you what they mean, what further tests may need to be done and review your symptoms. Proper rheum DX is not based only on test results, but exam findings and symptoms of patient. Good luck. ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Av test positive .Ra factor positive .Joint pain .Ccp antibody test negative.Raised esr.Plz diagnose my disease.

Cannot diagnose: Although these lab values are interesting, taken out of the context of your symptoms and findings on physical examination, plus further testing there is no way in which to diagnose over the internet. See a rheumatologist and get appropriately assessed. ...Read more

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What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic.. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

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(Biopsy DLE Inconclusive)ds-DNA Normal.Weak Positive ANA,ENA R Positive ANT RNP positive FBC &Urine Ok.Photosen,Rash face&Ears blister fingers... SLE?

(Biopsy DLE Inconclusive)ds-DNA Normal.Weak Positive ANA,ENA R Positive ANT RNP positive FBC &Urine Ok.Photosen,Rash face&Ears blister fingers... SLE?

No: DLE , even if you have it, does not necessarily translate into SLE in the absence of other system involvement. True blisters are not usually found with DLE. Have you been checked for porphyria? ...Read more

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Can ANA test be false negative for lupus?

Lupus: Has specific criteria for diagnosis, ANA is just one of them and canot be relied on by itself for a diagnosis. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?

Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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Is positive anticardiolipin and positive antidsdna needed for lupus diagnosis? I have positive Ana, WBC 4.20 skin rashes, plus arthritis in joints

Rheumatologist: Anticardiolipin antibodies may not be present in many lupus cases but Ana and antidsdna findings are common. Your findings are consistent with lupus, but the rheumatologist is best qualified to evaluate and advise you about diagnosis and treatment. ...Read more